>Epiperipatus MSHRKFSAPRHGSMGFVPKKRCKRHQGKIKAFPKDDPSKPVHLTGFMGFKAGMTHIVREV DKPGSKVNKKEVVEPVTILETPPMVIVGVVGYIETPRGLRSLKTIFAEHLNEECRRRFYK NWYKAKKKAFTKYAKKWQDEAGKKEIERDFSTMMKYCKVIRVIAHTQIKLLRKRQKKANI MEIQLNGGTIADKVNWAREHLEKQVPVSKVFAQDEFIDVIGITKGHXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXSARGLVPKKPSNPPGTIIKSIGGE-KNGGQRVVKLI RSSRYYPTEDFPRRKRKVG--PRKEKKTPALRKSITPGTILIILAGVQRGKRVIFLKQLK -SGLLLVTGPYKINRCPLRRVNQAYVIATQTKIDISGIEIPDHINDDYFKRVKS-PKSKN V---EA-EIFE-TKHQEYKPSEQRKQDQVEMDKAIIAVLKKHPKRRLLFLYLNRLFTLKX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFGTRLGHKKVLHSHNRAMIGIVAG GGRIDKPMLKAGRAYHKYKAKRNCWPKARGVAMNPVEHPHGGGNHQHIGKASTARRDASA GRKVELIAARKTGIIRGDTTSL---KKGQ-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKARVDEFPLCVHLVSDEYEQLSSEALEAGRICANKYLVKYCGKDAFHIRMR VHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVNIGQPIMSVRAKENHKAQVIE ALRRAKFKFPGRQKIHVSKKWGFTKWDASEFEKLRAEGILVPDGFYCKYRNGRGPLYVWK KAQFENVIQAMQVETKSKDSAKKPKKKEDQAAKTAVRLALNATRHVKETSTKVRRPEKKE GKERDKNPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILEKGLRVREYELRKSNFSNTGNFGFGIQEHIDVGIKYDPSI GIYGLDFYVVLGRAGFSISQRKRKQSKIGAKHRIKRGNAMKWFQAKXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXIQNQQATISVVPSAAALIIKALKEPPRDRKKQKNIKHSGNVSFDDIVSI ARQMR-RSMARKLQGTVKEILGTAHSVGCTVEGCNPRDVIEKVNS-EMEVPEDMAR--YS MDPENATKSCKARGSNLRVHFKNTRETAQAIKKMHLRRATRYLKNVINKKEIVPFRRFNG GVGRKAQCKNWKCTQGRWPKKSAEFLLQLLKNAESNAEYKGLDSDHLVIEHIQVNRAPKM RRRTYRAHGRINPYMSSPCHIEVILTEKEQAVPKPLS-DEEQP-KKKIS-KKK-LARQK- MMQR-DMGKIMKPGRVVLVLSGRFAGRKAVIVKNNDDGSSDKQYGHALVAGVERYPRPVT AKMPQRKIIKRCKIKPFIKIYNYNHLMPTRYSV-DVAIDKSLVNKESFKEPTLKKRAKRD IKVKFEERYKTGKNRWFFQKLRFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXMGTPDVRIDTRLNKHVWSRGVRSVPFRIRVRLSRRRNEDE DSVHKLYTLVTYVPVASFKGLQTINVD-NEDMVQRLTFRRRLPYNTASNRRRVSKTPGGR LVYLYQKKSKSIPK--CGDCKVKLHGITPSRAKERKNMTKRHKTVSRTYGGTRCPNCVRS RIVRAFLIEEQKIVVRVLKAQQQAAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXMPKQIMEIKDFLLTARRKDAKAVKIKKNPDNV-KFKVRCSRYLY TLVIH-DREKAEKLKQSLPPGLQVKELKMASHKTFKIKQKLAKKQNQNRPIPQWIRMRTG NTIRYNAKRRHWRRTKLKL----M-A--SKDELACVYSALILQDDDVAITGEKIATILKA ANVD-VEPFWPGLFARALEGIDIKSLITNIG-SGV--AAPAGGAAAG--GGAAAAA---- -PPKEEPKKEEKK--KEE-SEE-SDEDMGFGLFDXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDLKEVVNKLIPDSIGKDIEKAC HGIYPLYDVFVRKVKVLKKPKFDLGKLL-LHGEGASSDAAKAGETGVK------IDRP-- DGYEPSILDSVMG-RGPKKHL-KRLNAPKHWMLDKLSGVFAPKPSSGPHKTRECLPLILF LRNRLRYALTGEEAKKIVRQRLIKVDGKIRTDLTFPAGFMDVITIEKIGENFRLIYDVKG RFAIHRITPEEAKYKLCRVRRVQTGPKGIPFLVTHDGRTIRYPDPLIKVNDTIQVDIESG KILDFIKFDSGNLCMITGGHNLGRVGTVTHRERHPGSFDIVLVKDALGHEFATRLSNVFI IGKGNKPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXTSDIPEIKLFGRWSSDDVQVSDIGLTDYIAVKEKSAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAARIVKHAFEIIHLLTGENPLQVLVN AIINGGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MFSAGA-KIKKPLGEKPDE FEASISQALLELEMNSDLKAQLRELQISAAKEIDVSG-KKAIIIFVPVPQLKSYQ-KIQT RLVRELEKKFSGKHVVFIAQRRILPKPTRKTRIK-NRQKRPRSRTLTAVHDAILEDLVYP AEIVGKRIRIRLDGTRLIKVHLDKNQQTNIEHKTETFSAVYKKLTGKEVIFEFP-EPYL- -XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEYGLRNKREVWRVKYTLAKIRKAAR ELLTLEEKDPRRLFEGNALLRRLVRIGVLDESRMKLDYVLGLRIEDFLERRLQTQVFKLG LAKSIHHARILIRQRHIRVRKQVVNVPSFIVRLDSQKHIDFSLKSPFGGXXXXXXXXXXX XXXXXXXXXXXXXXXXXMLMPKKNRTAIYEYLFKEGVLVAKKDFHAPEHPALEN--VPNL HVIKAMQSLKSRGYVKEQFAWMHYYWYVTNEGIQFLRDYLHLPPEIVPATLKRQTRTDAA RPRPKTSGF----GEDRTPRGMSDREGYRRSAAP---LS-DKKGDVGLGGAT-MEFRGXX XXGRGRGAS-----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMDVHTA LQEVLKVALMHDGLARGLHEAAKALDKRQAHLCVLSNNCDEPMYVKLVEALCAEHQINLI KVDDNKKLGEWAGLCKIDKEGKARKVVGCTCVVVKDYGKEAQAHDVLADYFKSKR----- -------MSESAEQ------KKKRTFRKYTYRGVDLDQLLDMTSEQLMELMHARARRRFT RGLKRKPMALIKRLRKAKKEAGPLEKPEVVKTHLRDMIIVPEMVGSVIGVYNGKAFNQVE VKPDMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKXKVAKKG------PIQAVQVF GRKKTATAVAYCKRGKGLLKVNGRPLELIEPQLLKYKLLEPILLLGRERFAGVDIRVRVK GGGSVAQIYAIRQAISKALVAYYQKYVDEASKKEIKDILIQYDRSLLVADPRRCEPKKFG GPGARARYQKSYRXXXXXXXXXXXKTVKRAARMIIEKYYTRLTLDFHT-KRIVEEVALV- TKRLR-KIAGFVTHLMKRIQHGPVRGISIKLQEEERERRD-YVPEVSAIEQ-DIIEVDPD TKEMLKMLEFA-IPGLQVTQPITQVGFRGQRV---------------------------M SHY----KDPGKP--ASEEAQ----IHRIRITLTGRSVKSLEKVCSDLIRGAKEKQLHVK GPVRIPTKVLRITTRKTPCGEGSKTWDRFQMRIHKRVIDLHSPSEIVKQIXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXLEASGD-ETIYHLKTLLAQTLDIN-ADDQLLTWNGH --PLNDYDILSDAGLTD-LATLDLRDRLLGGKVHGSLARAAKVKGQTPNVXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX >Drosophila MSHRKFSAPRHGSMAFYPKKRSARHRGKVKAFPKDDASKPVHLTCFIGYKAGMTHIVREA DRPGSKINKKEVVEAVTVLETPPMIVVGAVGYIETPFGLRALVNVWAQHLSEECRRRFYK NWYKSKKKAFTKASKKWTDDLGKKSIENDFRKMLRYCKVIRVIAHSQIRLIKQRQKKAHV MEIQLNGGSIEDKVKWAREHLEKPIQVSNVFGQDEMIDCVGVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVSTTVARAGQKGYHHRTEINKKIYRIGAGIHTKDGKVIK NNASTEYDLTDKSITPMGGFPHYGEVNNDFVMIKGCCIGSKKRIITLRKSLLKHTKRSAL EQIKLKFIDTSSKMGHGRFQTPADKLAFMGPLKKDRLKEEAAATTAAAAAATTTSA---- ----------------------MAP--IE------KAKKV--AKSAKKGKKHPVNSYLKG GILRYSKAQMYKRR-----ALYRLKDKKSPVVEKAKVPIKKVKKIGGP-KNGGERTVFLK KSKASYPTKTFVKKRPSKA---NFSEHKRNTRRNLTPGTVLILLAGRHQGKRVVLLKVLA -SGLLLVTGPFALNSCPLRRVSQRYVIGTSSKVDLGAFKVPEHLNDAYFRRLKA-KKDKK TG--EA-DIFA-AKKERFVPNEQRKKDQKEVDAALLKVIKAHPEGKFFAKYLQNMFALHS SQYPHRMRFMGRVIRAQRKGAGSVFKAHVKKRKGAAKLRSLDFAERSGYIRGVVKDIIHD PGRGAPLAVVHFRDPYRYKIRKELFIAPEGMHTGQFVYCGRKATLQIGNVMPLSQMPEGT IICNLEEKTGDRGRLARTSGNYATVIAHNQDTKKTRVKLPSGAKKVVPSANRAMVGIVAG GGRIDKPILKAGRAYHKYKVKRNSWPKVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTSA GRKVGLIAARRTGRIRGGKGDS---KDK--MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKATVEDFPLCVHLVSDEYEQLSSEALEAGRICCNKYLVKYCGKDQFHIRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVRIGQPIMSVRSSDRYKAQVIE ALRRAKFKFPGRQKIYVSKKWGFTKYERERYEELRDDNRLEPDGCNVKYRPEHGPIAAWE KAQRDVYA--------------------------------------------MAAVTKKI KRDPAKNPMRDLHIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILERGLKVREYELRRENFSSTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGYNVNHRKRKSGTVGFQHRLTKEDAMKWFQQKYDGIILNTKK---- --------MPPKFDPTEVKLVYLRCVGGEVGATSSLAPKIGPLGLSPKKIGDDIAKATSD WKGLKITVCLTIQNRQAAISVVPSAASLIIKALKEPPRDRKKQKNIKHSGNIGFEDILAI ARVMRPRSMARELKGTCKEVLGTAQSVGCTVDGKHPHDVIDELNEGSIEVPAEMGR--YS RESDNVAKSCKARGPNLRVHFKNTHETAQAIKRMPLRRAQRYLKAVIDQKECVPFRRFNG GVGRCAQAKQWKTTQGRWPKKSAEFLLQLLRNAEANADCKGLDADRLVVHHIQVNRAQCL RRRTYRAHGRINPYMSSPCHVEVILTEKEELVSKAT---DDEPAKKKLS-KKK-LQRQKE KMLRSEMRKIMKQGKIVIVLSGRYAGRKAIIVKTHDDGTPEKPFGHALVAGIDRYPRKVT KKMGKNKLKKKSKVKPFLKSLNYNHLMPTRYTAHDISFE-KLSPKD-LKDPVKRKTHRFQ TRVKFESVYKEGKNKWFFQKLRFMT----KTKGEKINKSAINEVVTRECTIHLAKRVHNI GFKKRAPRAIKEIRKFAEREMGTTDVRIDTRLNKHIWSKGIRSTPFRIRVRLARRRNDDE DSPNKLYTYVTYVPVSTFKNLQTENVESSDDMVQRLTLRRRLSYNTRSNKRRIVRTPGGR LVYQYVKKNPTVPR--CGQCKEKLHGITPSRPSERPRMSKRLKTVSRTYGGVLCHSCLRE RIVRAFLIEEQKIV-KALKSQREALVKPVKKVVEKKPVKAAAKKPAGKAAGKPGAKVAGK KPAPKGAPKGVVKSKKMPREIKEVKDFLNKARRSDARAVKIKKNPTNT-KFKIRCSRFLY TLVVQ-DKEKADKIKQSLPPGLQVKEVKMAAHKSFRIKQKLAKKLKQNRSVPQWVRLRTG NTIRYNAKRRHWRRTKLKL----M-S--TKAELACVYASLILVDDDVAVTGEKINTILKA ANVE-VEPYWPGLFAKALEGINVKDLITNIG-SGVG-AAPAGGAA----PAAAA-AA--- --PAAESKKEEKK--KEEESDQ-SDDDMGFGLFDMAVGKNKGLSKGGKKGGKKKVVDPFS RKDWYDVKAPNMFQTRQIGKTLVNRTQGQRIASDYFKGRVFEVSLVPDLQKDIDPEHSFR KFRLIAEDVQDRNVLCNFHGMDLTTDKYRSMVKKWQTLIEAIVEAKTVDGYLLRVFCIGF TAKDQQSQRKTCYAHESQVRKIRSGRMTDIITNEVSGADLKQLVNKLALDSIAKDIEKSC QRIYPLHDVYIRKVKVLKKPRFDVSKLLELHGDGGGKSVEAVV-SSEG----APKSTA-- LKVKPPVQESVMA-RGPKKHL-KRLAAPKAWMLDKLGGVFAPRPSTGPHKLRESLPLLIF LRNRLKYALNGAEVTKIVMQRLVKVDGKVRTDPTYPAGYMDVITLEKTGEFFRLVYDVKG RFVIHRISAEEAKYKLCKVKKTQLGAKGVPFLVTHDGRTIRYPDPLIHANDSVQVDIASG KITDYIKFDSGNLCMITGGRNLGRVGTVVNRERHPGSFDIVHIKDSQGHVFATRLTNVFI IGKGNKPYISLPKG-KGVKLSIAEERDKRLAAKTH-------MAEVAENVVETFEEPAAP MEAEVAETILETNVVSTTELPEIKLFGRWSCDDVTVNDISLQDYISVKEKFARYLPHSAG RYAAKRFRKAQCPIVERLTCSLMMKGRNNGKKLMACRIVKHSFEIIHLLTGENPLQILVS AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MAIGS--KIIKPGGSDPDD FEKSIAQALVELEANSDLKPYLRDLHITRAREIEFGS-KKAVIIYVPIPQQKVFQ-KIQI ILVRELEKKFSGKHVVVIAERKILPKPTRKARNPL-KQKRPRSRTLTAVYDAILEDLVFP AEIVGKRIRVKLDGSQLVKVHLDKNQQTTIEHKVDTFTSVYKKLTGRDVTFEFP-DNYLN VMVNGRIPSVFSKTYVTPRRPYEKARLDQELKIIGEYGLRNKREVWRVKYALAKIRKAAR ELLTLDEKDEKRLFQGNALLRRLVRIGVLDESRMKLDYVLGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFVVRLDSQKHIDFSLKSPFGGGRPGRVKRKNL KKNQGGGG-GAAEEEEDMFMPKAHRVAIYEYLFKEGVIVAKKDFHAQKHPELES--IPNL HVIKAMQSLHSRGLVKEQFAWRHYYWYLTNEGIEELRSYLHLPPEIVPSTLKRPARSETV RPRPAVGGPR-GPGDAS--KTGEDRSAYRRAPGGS--GV-DKKGDVGPGAGE-VEFRG-G F-GRGSRN--------------------M-ADVDVD-------VPSAAPVLDGAMDINTA LQEVLKKSLIADGLVHGIHQACKALDKRQAVLCILAESFDEPNYKKLVTALCNEHQIPLI RVDSHKKLGEWSGLCKIDKEGKPRKVCGCSVVVIKDFGEETPALDVVKDHLRQNS----- -------MADQVDENL----KKKRTFKKFTYRGVDLDQLLDMPNNQLVELMHSRARRRFS RGLKRKPMALIKKLRKAKKEAPPNEKPEIVKTHLRNMIIVPEMTGSIIGVYNGKDFGQVE VKPEMIGHYLGEFALTYKPVKHGRPGIGATHSSRFIPLKMQQKRRE------PVQAVQVF GRKKTATAVAYCKRGNGLLKVNGRPLEQIEPKVLQYKLQEPLLLLGKEKFAGVDIRVRVS GGGHVAQIYAIRQAISKALVAFYQKYVDEASKKEIKDILVQYDRTLLVGDPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKAAKVIIEKYYTRLTLDFHTNKRICEEVAIIP TKPLRNKIAGYVTHLMGRLRHSQVRGISIKLQEEERERRDNYVPAVSALEQ-DIIEVDAD TKEMLKLLDFHNIRGLQLTQPNTNNFGRRN-----------------------------M AAAP---KDIEKPH-VGDSAS----VHRIRITLTSRNVRSLENVCRDLINGAKNQNLRVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRIIDLHSPSEIVKKITSINIEPGVE VEVTIAN---MG--KPRGLRTARKHVNHRRDQRWADKDYKKAHLGTRWKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGSLNYIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYSTPKKIKHKRKKVKLA VLKYYKVDENGKIHRLRRECPGENCGAGVFMAAHEDRHYCGKCNLTFVFSKPEEK----- -----MQLFVRGLET------IEALEVSQD-ATIAGVKNQLAQIHGFN-AEEFSLDCEGI --TLAN--ETPVT--ALSSFELDLNIPMLGGKVHGSLARAGKVKGQTPKVEKQEKKK-KK TGRAKRRIQYNRRFVNFVQ-GFGRRRGPNANST-------- >Anopheles MSHRKFSAPRHGSMAFYPKKRASRHQGRVKAFPKDDASKPVHLTAFLAYKAGMTHIVREA DRPGSKINKKEVVEAVTILETPPLVVVGAVGYIETPFGPRALCNVWAQHLSEECRRRFYK NWHASKKKAFTKASKKWTDDLGKKSIEDTFKKMVRYCKFIRVIAHSQIRLIKQGQKKAHI IEIQLNGGSIADKVNWVKEHLEKPIPVSQVFSQDEMIDCVAVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVAFTVARAGQKGYHHRTELNKKIYRLGAGIHTKDGKVIK NSAATEYDLTDKSITPMGGFPFYGEINQDFLMIKGCCIGAKRRVITLRKSLLVHTKRSAL EQIKLKFIDTSSKMGHGRFQTPADKRAYMGVLKKDRIREEKAQAA--------------- ----------------------MAPKETKAAAPAKAVKKVRKAPKKVQKVSKYPASLLTA GLYRAVRSRMVKTR------LPLSAKTVDPAKVKPKKPVTIVKKIGGA-KNGGERTVLLR KNKANLPTKRFAHKRPAKR---CFRNHKRNIRKSLKPGKVLILLAGRHKGKRVVLLKTLK -TGLLLVTGPFQLNSCPMRRIAQNYVIATTTRVNLRGVKVPEHIDDRYFRRVHP-KKDSR T---ER-DIFA-RKEFKYVPTEQRKADQKTVDTAVMAAIKAHPEGKLIQRYLKSMFSLRT NMFPHRMKFMGRVIRAQRKGAGSVFRSHTKRRKGAPKLRSLDFSERHGYIKGVVKDIIHD PGRGAPLAVVHFRDPYKFKTRKELFIAPEGMYTGQFLYCGKKANLQIGNVMPVGQMPEGT IVCNLEEKTGDRGRLARASGNYATVIAHNPDTKKTRVKLPSGAKKVIPSNNRAMVGIVAG GGRIDKPILKAGRAYHKYKAKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTSA GRKIGLIAARRTGRIRGGKTDT---KKDD-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKACVEDFPLCVHLVSDEYEQLSSEALEAGRICCNKYLVKFCGKDQFHIRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPIMSVRSSDRFKAQVIE ALRRAKFKFPGRQKIFVSKKWGFTKYDRDVYQKHNDEGRLVPDGCGVQFRNDHGPLVKWE QHQRNRLSA--------------------------------------MPAKDEKTAKPAA GKDKSKNVMRDLRIRKLCLNICVGESGDRLTRAAKVLEQLTNQTPVYSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILERGLKVREYELRRDNFSQTGNFGFGIQEHIDLGIKYDPTI GIYGLDFYVVLGRPGYNVAQRRRKMGKIGFIHRLTKEDAMKWFQQKYDGVILNSKAK--- --------MPPKFDPNEVKHVYLRCVGGEVGATSSLAPKIGPLGLSPKKIGDDIAKATGD WKGLKITVCLTIQNRQAAISVVPSAASLIVKALKEPPRDRKKVKNIKHNGNITFDEVINI ARVMRPRSMARELAGTCKEVLGTAQSVGCTIDGRSPHDVIDDISSGAIEIPSEMGR--YA KEPDNASKSCKSRGSNLRVHFKNTRETALAIKRMPLRRAQRFLKNVIEKKECVPFRRFNG GVGRCAQAKHWGTSVGRWPKKSAEFLLQLLKNAEANADYKGLDVDRLVINHIQVNRAPCL RRRTYRAHGRINPYMSSPCHIELSLTEKEDVVTKAT--DESEQAKKKLS-KKK-LQRQKE KMMRNEMGKIMKSGKVVLVLGGRYAGRKAIIMKTFDDGTSDKQFGQALVAGIDRYPRRVT RNMSKDRIHKRCKIKPFIKMLNYNHLMPTRYSVPDVNLDSKYSVAD-MKDPAKRKKARNQ IRCKFEERHKTGKNKWFFQKLRFMV----KAKREKKPKSAINEVVTRECTINLNRRLHKV GYKKRSPRAIKIVRKFAEKEMGTTDVRIDTRLNKAIWHRGIRNPPFRIRVRLSRRRNDDE DSPNKLYTLVTYVPVPTFKELQTENVESTEDMVQRLTLRRRLSYNTKSNKRRIVRTPGGR LVYQYVKKRRTLPK--CGQCKKELNGIKPSRPCERPRMSRRLKTVTRTFGGVLCHHCLRE RIIRAFLIDEQKVV-KVLRAQQQAKPVGKPVKAPKTTKTTKAGASKSK------------ ----------------MPQEIKEVKDFLIKARRKDARAVKIKKNETNT-KFKIRCSRYLY TLVVK-DMEKAEKLKQSLPPGLQVKEVKMASHKTFRIKQKLAKKLKQNRPIPQWIRMRTG NTIRYNAKRRHWRRTKLKL----M-AL-NKAELACVYSALILVDDDVAVTDEKIATILKA ANVD-IEPYWPGLFAKALEGIDVKSLITSIG-SGVGSGGGA--------PAAAAGGAGAA --PAAAEKKEEK---KEEEPEE-SDDDMGFGLFGMAVGKNKGVSKGGKKGSKKKVVDPFT RKDWYDVKAPNMFKNRQVGKTLVNRTQGTKIASDGLKGRVFEVSLA-DLQNEPDAERSFR KFKLVAESVNGRDVLTNFHGMALTTDKLRSMVKKWQTLIECSVDVKTTDGFMLRVFCIGF TIKDSMSQRKTCYAQHSQIKNIR-AKMTAIIKREITSTDLKGVVEKLLPDSIAKDIEKAC QVVYPLHDVYIRKVKVLKKPRFDLSSLMELHGDGGGKAAEVSTGAASG----VVVDRP-- EGYEPPVQASVMA-RGPKKHL-KRLNAPRGWMLDKTGGTFAPRPSTGPHKLRESLPLVIF LRNRLKYALTNSEVTKIVMQRHVKIDGKVRTDPNYPAGFMDVINIHKTGEYFRLIYDVKG RFTVHRITSEEAKYKLLKVKRVQIGPKRVPFLLTHDGRTIRYPDPQIHQHDSIQYDIATG KVLDVLKFEPGNLCMITGGRNLGRCGTVILREKHPGSFEIVHVKDTTGHVFATRLSNVFI IGKSTKAYISLPKG-KGVKLTIAEERDRRLANKAAQ-MADEAFENFDEEAAAPQEMDDAV QDDQAAQVYEEAPVVQTAELPEIKLFGRWSSDDIDISDISVSDYIAVKEKHAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMKGRNNGKKLKAVRIVRHAFEIMHLLTGENPLQIVVH AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTVAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MVFGS--KVIKAGNGEPDA FETQIGQAILELEMNSDLKPQLRDLYITRAREVEFNN-KKAIIIYVPVPKQKAFQ-KVQT RLVRELEKKFSGKHVVFIAERRILPKPMRGRRDP-NKQKRPRSRTLTAVYDAILEDLVFP AEVVGKRIRVKLDGSQLIKVHLDKNQQTTIEHKVDTFASVYKKLTGRDVTFEFP-ENYL- -MVNHRIPSVFSKTYVTPRRPFEKPRLDAELKIIGQYGLRNKREVWRVKYTLAKIRKAAR ELLTLEEKDEKRLFQGNALLRRLVRIGVLDESRMKLDYVLGLRIEDFLERRLQTQVFKLG LAKSYHHARVLIRQRHIRVRKQVVNVPSFIVRLDSQKHIDFSLKSPFGGGRPGRVKRKNL KKGQGGGG-AAEEEEEDMFMPKAHRVAIYEYLFKEGVLVAQKDFYAPKHPELEN--IPNL HVIKTMQSLKSKNFVKEQFAWRHYYWYLTNEGIEYLRAFLHLPSEIVPSTLKRAARSEPQ RARTQ-AGPR---PEGP--KTGEDRQAYRRMQQAA--PA-DKKGDVGVGAGE-LEYRG-G F-GRGNRM--------------------M-SDVEVE-------APSA-PV-DGSMDVNTA LQEVLKKSLIADGLVHGIHEACKALDKRQAVLCILAESCDEPQYKKLITALCNEHQIPLI RVDSNKKLGEWSGLCKIDKEGKPRKICGASCVVLKDFGEETPALDVIKEHLRQTA----- -------MADQAPEDGT---KKKRTFRKFTYRGVDLDQLLDMKQEALVELMHSRAKRRFK RGQRRKPQALIKKLRLAKKNTPPNEKPACVKTHLRNMIIVPEMVGSTVGVYNGKTFNQTE IRPDMIGHYLGEFSMTYKPVKHGRPGIGATHSSRFIPLKMLQARKEK------VNAVQVF GRKKTATAVAHCKRGKGLLRINGRPLDQIEPKILRYKLQEPLLLLGKEKFAGVDIRIRVS GGGHVAQIYAIRQAISKALVSFYQKYVDEASRKELKDILTQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTIKKASKVIIEKYYTRLTMDFDTNKRIVEEVAIIP TKPLRNKIAGFVTHLMKRLRHSQVRGISIKLQEEERERRDNYVPDVSALEQ-DIIEVDPE TKEMLKHLDFNNIVV-QLTNPTAPGYSNRRN----------------------------M AAVAT--KDIEKP--VVETAT----VHRIRITLTSRNVRSLEKVCADLIAGAKKQKLRVK GPVRMPTKILRITTRKTPCGEGSKTWDRFQMRIHKRIIDLHSPSEIVKQITSINMEPGVE VEVTIADP--MG--KPRGIRTARKHIRHRRDQRWADKDYKKAHLGTRWKSNPFAGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNYIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYSTPKKIKHKRKKVKLA VLKYYKVDENGKIHRLRRECTSESCGAGVFMAAHEDRHYCGKCHLTLVYSKQEEK----- -----MQLHVRGLN-------THVLDVQPG-DSISHVKAVLAGLESVD-AQELNLYCEGV --PLGE-DVT-VSQLTS--VELDLTVSLLGGKVHGSLARAGKVKGQTPKVEKKEKKK-KK TGRAKRRIQYNRRFSSVVQ-AYGRRRGPNANSA-------- >Aedes MSHRKFSAPRHGSMAFAPRKRASRHQGRIKAFPKDDPAKPVHLTAFLAYKAGMTHIVREA DRPGSKINKKEVVEAVTILETPPIVVVGAVGYIETPFGPRALCNVWAQHLSEECRRRFYK NWHASKKKAFTKASKKWTDDLGKKSIEDNFKKMIRYCKFIRVIAHSQIRLIKQGQKKAHI IEIQLNGGTIEDKVNWVKEHLEKPVPVADVFRQDEMIDCVAVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVAFTVARAGQKGYHHRTEINKKIYRIGAGIHTKDGKVVK NSAATEYDLTDKSITPMGGFPFYGEINNDFLMIKGCCIGAKRRIITLRKSLLVHTKRASL EQINLKFIDTSSKMGHGRFQTPADKRAYYGVLKKDRIREEKAQAAAAAAAAKSSA----- ----------------------MAP--TKEKAAAA-----KKGEKTVKKSAGAKTGSLTD GVRRYLKRKQRVQK-----KLFSLKNVKRVRAEKPKVAITVVKKIGGA-KNGGERTVLLK KNKSFLPTKSLVRKRSGKK---CFRNHKRNIRKTLKKGKILILLAGRHKGKRVVLLKALK -SGLLLVTGPFALNSCPMRRISQNYVIATKTRVNLKDYKVPKHINDTYFRRQPK-KKNSR T---ER-DIFA-EKVEKYVPSEQRKTDQKAVDDAVLKAIKKHKDGKVVQRYLKSMFSLRS NQFPHRMQFMGRVIRAQRKGAGSVFTAHTKKRKGEPKLRALDYAERHGYLKGTVKQIIHD PGRGAPLAVVHFRDPYKFKLRKQLFIAAEGMYTGQFVYCGKRAQLQIGNVLPIGLMPEGT IVCNLEEKTGDRGKLARTSGNYASVIAHNPDTKRTRVKLPSGAKKVLPSANRAMVGIVAG GGRIDKPILKAGRAYHKYKVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTPP GRKVGLIAARRTGRIRGGKGDEKFKEKEKKMGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKAAVEDFPLCVHLVSDEYEQLSSEALEAGRICCNKYLVKFCGKDQFHIRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVNIGQPIMSVRSSDRFKAQVIE ALRRAKFKFPGRQKIFVSKKWGFTKYDRDEYLKHQEEGRLVNDGCGVQFKNDHGPLAKWE QHQRNRFGV---------------------------------------------MATKTA SKDKSKNIMRDLRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVYSKARYTVRSFGIR RNEKIAVHCTVRGFKAEEILERGLKVREYELRRDNFSQTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGYNVAQRRRKTGKIGFIHRLTKEDAMKWFQQKYDGIILNSKAK--- --------MPPKFDPNEIKHVYLRCVGGEVGATSSLAPKIGPLGLSPKKIGDDIAKATGD WKGLKITVCLTIQNRQAAISVVPSAASLIVKALKEPPRDRKKVKNIKHNGNITFDEVISI ARVMRPRSMARELSGTCKEVLGTAHSVGCTIDGRSPSDVIDDINSGAIECPAEMGR--YA KEPDNPAKSCKARGSNLRVHFKNTRETALAIKRMPLRRAQKFLKNVCEKKECVPFRRFNG GVGRCAQAKHWNTSVGRWPKKSAEFLLQLLKNAEANADYRGLDVDRLVVDHIQVNRAPCL RRRTYRAHGRINPYMSSPCHIELSLTEKEDVVSKAA---ENEPAKKKLS-KKK-LQRQKE KMMRNEMGKIMKTGKVVLVLGGRYAGRKAIILKTFDDGTSDKQFGHALVAGIDRYPRRVT RRMNKTRLHKRSKIKPFIKMLNYNHLMPTRYSVPDVSLDTKYSAKD-LKDPVKRKKARFQ VRVKFEERHKSGKNKWFFQKLRFMA----KTKTEKKAKSAINEVVTRECTINLNRRLHKV GYKKRAPRAVKIVRKFAEKEMGTNDVRIDTRLNKALWHRGIRNPPFRIRVRLSRRRNDDE DSPNKLYTLVTYVPVSTFKELQTENVESTEDMVQRLTLRRRLSYNTKSNKRRVVRTPGGR LVYLYVKKQRTVPK--CGQCKEKLSGIKPSRPSERPRMCRRLKTVTRTFGGVLCHRCLRE RIVRAFLIDEQKVV-KVLKAQQLGKPISKPPKIQKTPAKAASKSK--------------- ----------------MPQEIKEVKDFLIKARRKDARAVKIKKNENNT-KFKIRCSRYLY TLVVQ-DKEKAEKLKQSLPPGLQVKEVKMSAHKTFRIKQKLAKKLKQNRPIPQWIRMRTG NTIRYNAKRRHWRRTKLKL----M-AL-NKAELACVYSALILVDDDVAVTDEKISTILKA ANVD-IEPYWPGLFAKALEGINVKDLITNIG-SGVGTGGGAA-------PAAAAPGAA-- --PAAAEKKEEK---KEEEPEE-SDDDMGFGLFGMAVGKNKGTSKGGKKGSKKKVVDPFT RKDWYDVKAPNMFSNRQVGKTLVNRTQGTRIASDGLKGRVFEVSLA-DLQNDTDAERSFR KFKLIAEDVHGRNVLCNFHGMDLTTDKLRSMVKKWQTLIECSVDVKTTDGYLLRVFCIGF TIKDSVSQRKTCYAQHSQIKEIR-RKMTTIITRDVTSSDLKEVVNKLLPDSIAKDIEKSC QGIYPLHDVYIRKVKVLKKPRFDLANLLELHGDGGGKGAEVSTGAAEGG---VTIDRP-- EGYEPPVQESVMA-RGPKKHL-KRLNAPRGWMLDKTGGTFAPRPSTGPHKLRESLPLVIF LRNRLKYALTNTEVTKIVMQRHIKIDGKVRTDPNYPAGFMDVITIEKTNENFRLIYDVKG RFTVHRITPEEAKYKLLKVKRVQIGPKKVPFILTHDGRTIRYPDPIIHQNDSIQYDIATG KVMDVLKFEPGNLCMITGGRNLGRCGTVIQREKHPGSFEIVHVKDATGHVFATRLTNVFI IGKATKAFISLPKG-KGVKLSIAEERDKRLASKAAH---------------MSEVEAFDN FEEEQPQVFEQAPVVQPAELPDIKLFGRWSSDDIHISDISVSDYIAVKEKHAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMKGRNNGKKLKAVRIVRHAFEIMHLLTGENPLQIVVQ AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MVFGS--KVIKAGGAEPDA FEGQIGQAILELEMNSDLKPQLRDLYITRAREIEFNS-KKAIVIYVPVPKQKAFQ-KVQT RLVRELEKKFSGKHVVFIGERRILPKPQRGRRDP-NKQKRPRSRTLTAVYDAILEDLVFP AEVVGKRMRVKLDGSQLIKVHLDKNQQTTIEHKVDTFTSVYKKLTGRDVTFEFP-EPYL- -MVNHRIPSVFSKTYVTPRRPFEKPRLDAELKIIGQYGLRNKREVWRVKYTLAKIRKAAR ELLTLEEKDEKRLFQGNALLRRLVRIGVLDESRMKLDYVLGLKIEDFLERRLQTQVFKLG LAKSYHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLKSPFGGGRPGRVKRKNM KKGQGGSG-GADEEEEDMFMPKAHRVAIYEYLFKEGVLVAQKDFYAPKHPELEN--IPNL HVIKTMQSLKSKNFVKEQFAWRHYYWYLTNEGIEYLRSYLHLPPEIVPSTLKRAARSEPQ RARAA-AGPR--SADGP--KGGEDRQAYRRTQQAG--GP-DKKGDVGAGAGD-VEFRG-G F-GRGSK-----------PQ--------M-SDVEVE-------APVA-PV-DGTMDVNTA LQEVLKKSLIADGLVHGIHEACKALDKRQAVLCILAESCDEPQYKKLITALCNEHQIPLI RVDSNKKLGEWSGLCKIDKEGKPRKISGASCVVLKAYGEETPAHDVIREHLKQLRQSS-- -------MADTTEAEGV---KKKRAFRKFTYRGVDLDQLLDMKQDLLMELMHSRAERRLN RGTRRKPVALIKKLRKAKKNAPPNEKPAIVKTHLRNMIIVPEMVGSIVGIYNGKTFNQVE IKPEMIGHYLGEFSLTYKPVKHGRPGIGATHSSRFIPLKMVKARKE------PVNAVQVF GRKKTATAVAYCKRGKGLLRVNGRPLDQIEPKVLQYKLQEPLLLLGKEKFAGVDIRIRVS GGGHVAQIYAIRQAISKALVSFYQKYVDEASRKELKDILTQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASKVIIEKYYTRLTMDFHTNKRIVEEVAIIP TKPLRNKIAGFVTHLMKRLRHSQVRGISIKLQEEERERRDNYVPEVSALEQ-DIIEVDPE TKEMLKQLDFNNIVV-QVTNPSAQGYSRRN-----------------------------M AATG---KDVEKP--VAEAAT----VHRIRITLTSRNVRSLEKVCADLISGAKKQKLRVK GPVRMPTKILRITTRKTPCGEGSKTWDRFQMRLHKRIIDLHSPSEIVKQITSINIEPGVE VEVTIADP--MG--KPRGIRTARKHIRHRRDQRWADKDYKKAHLGTRWKSNPFAGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNYIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYSTPKKIKHKRKKVKLA VLKYYKVDENGKIHRLRRECTSETCGAGVFMAAHEDRHYCGKCHLTLVYSKQEEK----- -----MQLHIRGLN-------THVLDVQPQ-ESISQIKARLAALENVEDAAHLVLSCEGA --ILAT-DAL-VTDLSS--IELDLTIPLLGGKVHGSLARAGKVKGQTPKVEKKEKKK-KK TGRAKRRIQYNRNFANVVQ-AFGRRRGPNANST-------- >Bombyx MSHRKFSAPRHGSMGFYPKKRSRRHRGKVKAFPKDDPSKPVHLTAFIGYKAGMTHVVREP DRPGSKINKKEIVEAVTIIETPPMVCVGVVGYIETPHGLRALLTVWAEHMSEDCRRRFYK NWYKCKKKAFTKASKKWQDELGRKSIEKDFKKMIRYCSVVRVIAHTQMKLLKQRQKKAHI MEIQLNGGTIEDKVKWAREHLEKPIPVDSVFAQDEMIDCIGVTKGKGYKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVSFTVARAGQKGYHHRTEMNKKIYRIGQGIHKKDGKVIK NNASTEYDLSEKSITPMGGFPHYGEVNNDFVMIKGCCMGPKKRIITLRKSLRVHTKRAAL EKINLKFIDTSSKFGHGRFQTPADKAAFMGTLKKDRIREEAAATTTPAAAAHL------- ----------------------MAP--TQPKAAAKPAAAPAGALTKKKSTKKPRNYDLGN GVMRFSKSKMFHKK-----AKYKFIGKKNPKPEKPKKLTVVVKQIGGE-KNGGTRTVPLK RRKSFYPTQEKIRASSGGR---PFSKHVRRIRPNLKIGTVCILLAGRHAGKRVVLVGILP -SGLLLVTGPFAFNSCPLRRIPQRYVIGTSTRISLGNFKLPKHFNDDYFKKNKK-CVKRT VKRKEGDDIFA-TKKEKYVPSEQRKTDQKTVDEAVIKAIGARPDKKVLRGYLKAAFGLRS SQYPHRLRFMGRVIRAQRKGAGSVFVSHTKKRKGAPKLRSLDYAERHGYIKGVVKDIIHD PGRGAPLAVVHFRDPYKFKTRKELFIAPEGLYTGQFVYCGKKATLEVGNVMPVGAMPEGT IVCNLEEKMGDRGRLARASGNFATVIGHNPDAKRTRVKLPSGAKKVLPSSNRGMVGIVAG GGRIDKPILKAGRAYHKYKVKRNCWPYVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTSA GRKVGLIAARRTGRIRGGKTDT---KKET-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGKKRATVDDFPLCVHLVSDEYEQLSSEALEAGRICCNKYLVKNCGKDQFHIRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVRIGQPIMSVRSSDRWKAQVIE ALRRAKFKFPGRQKIYVSKKWGFTKYERDEFEKLREEGRLANDGCIVQYRPEHGPLDAWR KVQAEILNV---------------------------------MARVQPPALKKDKKEKKV PKDNSKNVMRNLHIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILERGLKVREYELRRDNFSATGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFNVAHRRRKTGKVGFPHRLTKEDAMKWFQQKYDGIILNSKAK--- --------MPPKFDPNEIKIVNLRCVGGEVGATSSLAPKIGPLGLSPKKVGDDIAKATSD WKGLKITVQLTVQNRQAQIAVVPSAAALIIRALKEPPRDRKKQKNIKHNGNISLEDVIGI AKIMRNRSMARYLSGSVKEILGTAQSVGCTVEGRPPHDLIDDINSGALTIDE-MGR--YS REPDNPAKSCKARGSNLRVHFKNTYETAMAIRKMPLRRAVRYLKNVIEKKECIPFRRFNG GVGRCAQAKQFGTTQGRWPKKSAEFLLQLLRNAESNADNKTLDVDRLVIDHIQVNRAPCL RRRTYRAHGRINPYMSSPCHIEVCLSEREDAVARVAPT-DDAPAKKKLS-KKK-LARQKE KMMRE-MGKIMKPGKVVLVLSGRYAGRKAIVVKNYDEGTSDKPYGHAFVAGIDRYPRKVH KRMGKNKIHKRSKIKPFVKVVNYNHLMPTRYTV-DFSFE-KFSAKD-LKDPAKRKKLRFN TRVRFEERYKSGKNKWFFQKLRFMA----KPKGERKGKSAINEVVTREYTVNLHKRLHGV GFKKRAPRAIKEIRKFAEKQMGTPDIRVDTRLNKFLWSKGVRNVPFRVRVRLSRRRNDDE DSAHKLFTLVTYVPVASIKGLQTENVDASQEMVQRLTFRRRLSYNTKSNQRRIVRTPGGR LVYQYVKKPKKIPR--CGQCKSKLRGIQPARPAERSRLCYRKKTVKRVYGGVLCHKCVKQ RIVRAFLIEEQKIV-KVLKAQQASTKSAKKATK--------------------------- ----------------MPREIKDIKDFLIKARRKDAKSVKIKKNPENV-KFKVRCSRFLY TLVIT-DKEKAEKLKQSLPPGLQVKEVKMSAHKTFIIKRKLAKKLKQNRPIPQWVRMRTG NTIRYNAKRRHWRRTKLKL----M-V--SKAELACVYSALILVDDDVAVTGEKISTILKA AAVD-VEPYWPGLFAKALEGINVRDLITNIG-SGVG-AAPAAGGA----PAAAA-AAGA- --PA-EEKKEEK---KEEEPEE-SDDDMGFGLFDMAVGKNKGLSKGGKKGVKKKIVDPFT RKDWYDVKAPSMFSKRQVGTTLVNRTQGTKIASEGLKGRVFEVSLA-DLQADTDAERSFR KFRLIAEYVQGRNVLCNFHGMDLTTDKLRWMVKKWQTLIEANIDVKTTDGYVLRVFCIGF TNKDSLSQRKTCYAQHTQVRAIR-KKMCEIITRDVTNSELREVVNKLIPDSIAKDIEKAC HGIYPLRDVCIRKVKVLKRPRFEISKLMELHGEGG-GGKGE---AGDK------SERP-- EGYEPPVQESVMA-RGPKKHL-KRLNAPKAWMLDKLGGVYAPRPSTGPHKLRECLPLVIF LRNRLKYALTGNEVLKIVKQRLIKVDGKVRTDPTYPAGFMDVVSIEKTNELFRLIYDVKG RFTIHRITPEEAKYKLCKVKRVATGPKNVPYLVTHDGRTIRYPDPLIKVNDSIQLDIATT KIMDFIKFESGNLCMITGGRNLGRVGTIVSRERHPGSFDIVHIKDSTGHTFATRLNNVFI IGKGTKAYISLPRG-KGIRLTIAEERDKRIAAKVAAQ--------------MAEENWNDD VAEAGSVVVETMSLPQAADIPEIKLFGRWSCYDVQVSDMSLQDYISVKEKYAKYLPHSAG RYAHKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAFEIIHLLTGENPLQVLVT AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECVA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------M--ST--KIIKASGAEADS FETSISQALVELETNSDLKAQLRELYITKAKEIELHN-KKSIIIYVPMPKLKAFQ-KIQI RLVRELEKKFSGKHVVFVGDRKILPKPSHKTRVA-NKQKRPRSRTLTSVYDAILEDLVFP AEIVGKRIRVKLDGSQLIKVHLDKNQQTTIEHKVDTFQSVYKKLTGREVTFEFP-EPYL- -MVNNRVPSVFSKTYVTPRRPFEKARLDQELKIIGEYGLRNKREVWRVKYTLARIRKAAR ELLTLEEKDPKRLFEGNALLRRLVRIGVLDEKQMKLDYVLGLKIEDFLERRLQTQVFKAG LAKSIHHARILIRQRHIRVRKQVVNIPSFIVRLDSGKHIDFSLKSPFGGGRPGRVKRKNL RKGQGGG--AANDEEEDMLMPKQNRVAIYEYLFKEGVMVAKKDYHAPKHTELEK--IPNL QVIKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIEYLRIFLHLPPEIVPATLKRSVRTETV RRGP-VG-----RPDAPA-RSAEDRSAYRRTPAAPGVAPHDKKADVGPGSAD-LEFKG-G Y-GRGRPAS-------------------M-ADVEVE-------VPTNPILSGNNMDVNVA LQEVLKTALIHGGLVHGLHEAAKALDKRQAVLCVLAENCDEAAYKKLVQALCNEHQIPLV KVDNNKKLGEWAGLCKIDKDGKARKIVGCSCVVIKDFGEETPALDVLKDYLKSSS----- -------MAEVDETL-----KKKRIFRKFTYRGVDLDQLLDMPNEQLMELMHARARRRFA RGLKRKPMALVKKLRRAKKEAPPNEKPEIVKTHLRNMIIVPEMVGSIVGIYNGKTFNQVE IKPEMIGHYLGEFSVTYKPVKHGRPGIGATHSSRFIPLKMAAVQEARRE---PIQAVQVF GRKKTATAVAYCKRGHGMLRVNGRPLDLVEPRLLQYKLQEPILLLGKEKFSMVDIRVTVK GGGHVAQVYAIRQAISKALIAFYQKYVDEASKKEIKDILVQYDRSLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKAAKIIIEKYYTRLTLDFDTNKRICEEIAIIP TKPLRNKIAGFATHLMRRLRHSQVRGISIKLQEEERERRDNYVPEVSALEH-DIIEVDPD TKDMLKMLDFNNINGLQLTQPATQGGYGGRRN---------------------------M AAAVVSGKDIEKP--QAEVSP----IHRIRITLTSRNVRSLEKVCADLINGAKKQKLRVK GPVRMPTKILRITTRKTPCGEGSKTWDRFQMRIHKRVIDLHSPSEIVKQITSINIEPGVE VEVTIADA--MG--KPRGIRTARKHVNHRREQRWADKEFKKAHMGTKWKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPRDGCLNHIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYSTPKKIKHKKKKVKLA VLRFYKVDENGKIHRLRRECTGEQCGAGVFMAVMEDRHYCGKCHSTMVF-KDDDK----- -----MQLHIRGQS-------THVLDVNGQ-ESIGQIKERIRTLAAVG-DEDLTLSLCGA --PLDD-SCL-VSELSS--SELDLTVPLLGGKVHGSLARAGKVKGQTPKVEKQQKKK-KK TGRAKRRIQYNRRFVNVVQ-TFGRRRGPNSNS--------- >Apis MSHRKFSAPRHGSMGFYPKKRSQRHRGKVKAFPKDDPSKPVHLTAFIGYKAGMTHVVREA DRPGSKVNKKEIVEAVTILETPPMIVVGVVGYIETPHGLRALTTVWAEHLSEDCRRRFYK NWYKSKKKAFTKASKKWQDDLGRKSIENDFKKIIKYCKVVRIIAHTQMKLLRQRQKKAHI MEIQLNGGTIEQKVQWAREHLEKPVPVSNVFAPDEMIDVIGVTKGKGYKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVSFTVARAGQKGYHHRTEMNKKIYRIGQGIHTKDGKIVK NNASTEYDLTEKTITPMGGFPHYGEVNNDFIMIKGCCMGPKKRVITLRKSLLVHTKRSAL EKINLKFIDTSSKFGHGRFQTAADKTSFMGQLKKDRMREEQQAQATTSAPSAANA----- -------------------MTDTKETNETKLKSPEKKEISSVKKGEKKGRIRPRNYDLGN GVYRFSRTRMFHKK-----AIYKFLSKKTPKSVKPKKPITIEKKISGD-KNGEKRIVLLK KRRANYPTADPVTVHHAKK---CFRDHRRYLRPSLKPGTICILLAGAHKGKRVVFLKQLK -SGLLLITGPFLINACPLRRVSQNYVIATSTRINISGLKIPSHINDDYFKRKRE-KRAKK E---EG-DIFS-KKKDEYKPSDQRKADQKVVDKFVISAIKRNKEKKMLFTYLSAMFGLRS SQYPHRLKFMGRVIRAQRKGAGSVFRSHTKRRKGAPKLRSLDFSERHGYIKGVVKDIIHD PGRGAPLAVVHFRDPYKFKTRKELFIAPEGMYTGQFLYCGKKANLQIGNVMPVGQMPEGT IVCNLEEKTGDRGRLARASGNYATVIAHNPDTKKTRVKLPSGAKKVIPSNNRAMVGIVAG GGRIDKPILKAGRAYHKYKAKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTSA GRKIGLIAARRTGRIRGGKTDT---KKDD-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGKKKASVEDFPLCVHLVSDEYEQLSSEALEAGRICANKYMVKNAGKDQFHIRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPIMSVRSSDRHKAAVVE ALRRAKFKFPGRQKIYVSKKWGFTKYDRAEYEELKAAGRLAPDGCNVKYLPEHGPLDEWK KFRKVLAAA----------------------------MADSKKSSEKKVEKRIEKKVRKE PKDASKNIMREVRIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILERGLKVREYELRKENFSGTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFNVAHRRRKTGKVGFQHRLTKEDAMKWFQQKYDGIIIAGKK---- --------MPPKFDPNEIKKVYLRCVGGEVGATSSLAPKIGPLGLSPKKVGDDIAKATSD WKGLKITVQLTIQNRQATISVVPSAASLIIKSLKEPPRDRKRQKNIKHNGNLSFDDIVSI ARSMRPRSMSKYLSGTVKEILGTCQSVGCTVEGRPPRDLIEEINGGKLQVPDEMGR--YS HEPVNASKSCKARGSNLRVHFKNTHETARAIKNMSLRRAQKYLKNVIEHKECVPFRRFNG GVGRCAQAKQFGTTQGRWPKKSAEFLLQLLKNAESNADVDGLDLDRLVINHIQVNHAPCL RRRTYRAHGRINPYMSSPCHIEVILTEKEDFVVKSP---EEEPSKKKLS-KKK-LARQKE KMMRE-MVKIMKTGKVVLVLSGRYAGRKAIIMRNYDDGTTEKQYGHAMVAGIDRYPRKVH KRMGKAKIHKRSKIKPFVKVLNYNHLMPTRYTV-DLHWD-KVTPKD-LKDPMKRKKIRFQ TRVKFEEKYKSGKNKWFFQKLRFMA----KSK-EKKGKSAMSEVVTREYTVNLHKRLHGV GFKKRAPRAIKEIRKFAEKQMGTPDVRIDTRLNKQLWSKGIRNVPFRVRVRLSRRRNDDE DSANKLYTLVTYIPVASFKGLQTENVDASQDMVQRLTYRRRLSYNTKSNRRRVVRTPGGK LVYQYLKKPKKIPR--CGQCKDKLRGIQPARPMERSRMCRRKKTVKRVYGGVLCHKCVKE RIVRAFLIEEQKIVIKVMKTHAFAKLKKTEKSFRFYLNKI-------------------- ----------------XPREIKEIKDFLLKARRKDAKSVKIKKNADNV-KFKVRCSRFLY TLVIT-DKEKAEKLKQSLPPGIXXXXXXMSAHKTFIIKRKLAKKLKQNRPIPQWVRMRTG NTIRYNAKRRHWRRTKLKL----M-N--KKAELACVYSTLILVDDDVAVTGEKIQTILKA ANVD-VESYWPGLFAKALEGVNIKELITNIG-SGVG-KAPAAA------PAAAAPA---- -STESAPAKEEK---KKEEPEPESDDDMGFGLFDMAVGKNKGLSKGGKKGVKKKIVDPFT RKDWYDVKAPSMFTNRHVGKTLVNRTQGTKIASEGLKYRVFEVSLA-DLQNDGDAERSFR KFRLIAEDVQHRNVLTNFHGMDLTTDKLRSMVKKWQTLIEANVDVKTTDGYLLRVFCIGF TNKDQLSTRKTCYAQHAQVKKIR-QKMVDTITNDVTKSDLKGVVSKLLPDATAKDIEKAS QGIYPLHDVYIRKVKVLKKPRFELSKLLELHGDGAGSKSEEVGESGSK------VDRP-- EGYEPPVQESVMA-RGPKKHL-KRLNAPKAWMLDKLGGVYAPRPSTGPHKLRESLPLVIF LRNRLKYALTNSEVTKIVMQRLIKVDGKVRTDANYPAGFMDVITINKTGEYFRLIYDVKG RFTTHRITAEEAKYKLCKVKRVQTGPKGIPFLVTHDGRTIRYPDPVIKVNDTIHLDIATG KILDSIRFDSGNLCMITGGRNLGRVGTVVSRERHPGSFDICHIKDSQGHTFATRLNNVFI IGKGTKPYISLPRD-KGVKLSIAEERDKRLAAKGVN------------------MAEMET YDDIVVPTTTTLPVALSAELPEIKLFGRWNCDDVQVNDMSLQDYIAVKEKNAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAFEIIHLLTGDNPLQVLVT AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MFPANA-KIIKSGGAEPDA FEASISQALLELEMNSDLKSQLRELYITKAREIETNN-KKCIIIYVPMPKLKAFQ-KIQT RLVRELEKKFSGKHVMFVGERKILPKPTRKTRTK-NKQKRPRSRTLTAVYDALLEDLVYP VEIVGKRIRIKLDGTQLIKVHLDKNEQTNIEHKVDTFAAVYKKLTGRDVTFEFP-ETYV- -MVNGRIPSVFSKTYVTPRRPYEKARLDQELRIIGEYGLRNKREVWRVKYTLANIRKAAR ELLTLEEKDPKRLFEGNALLRRLVRIGVLDESRMKLDYVLGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLKSPFGGGRPGRVKRKNL RKGSGG---AAPEEEEDMLMPKKNRVAIYEYLFKEGVMVAKKDYHAPKHPELEC--IPNL QVIKAMQSLKSKGFVKEQFAWRHFYWYLTNEGIEYLRGYLHLPPEIVPSTLKRQTRSETT RPRPAAGA----RSEAS--RPTEDRAGYRRGPGGPAGP-GDKKADVGAGTGD-VEFRG-G F-GRGK------------PQ--------M-SDVENDD------VP-SAMAAGGAMDVNTA LQEVLKNALIHDGVVHGLHEAAKALDKRQAMLCILAENCDEPMYKKLVQALCNEHQIPLI RVDNNKKLGEWAGLCKIDSAGKARKVVGCSCVVIKDFGEDTPAKDVVMEYVKQSSVH--- -------MAEAEETQ-----KKKRTFRKFTFRGVDLDQLLDMPNEQLMVLMHARARRRFS HGLKRKSMALVKKLRKAKKETPPNEKPEIVKTHLRNMIIVPEMVGSIVGVYNGKTFNQVE IKPEMIGHYLGEFSVTYKPVKHGRPGIGATHSSRFIPLKMQKKQKE------PIQSVQVF GRKKSATAVAYCKRGRGNLRVNGRPLELVEPRVLQYKLQEPILLLGKEKFSGVDIRVRVN GGGHVAQIYAIRQAISKALVAYYQKYVDEASKKEVKDILIQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MSRVRTKTVKKAAKLIIEKYYTRLTMDFHTNKRICEEIAIIP SKSLRNKIAGFVTHLMKRLRHSQVRGISIKLQEEERERRDNYVPEVSALEH-DIIEVDPE TKEMLQMLGFNNIPGLQLTQSQLPPYSRRS-----------------------------M AST--KVDNPEKP--GQEVTP----IHRIRITLTSRNVRSLEKVCSELINGANKQKLKVK GPVRMPTKILRITTRKTPCGEGSKTWDRFQMRIHKRVIDLYSPSEIVKQITSISIEPGVE VEVTIANE--MG--KPRGLRTARKHVNHRRDQRWNDKDYKKAHLGTRWKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNNIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYSTPKKIKHKKKKVKLA VLKFYKVDENGKIHRLRRECPMEQCGAGVFMAAMEDRHYCGKCGYTLVFNKPEDK----- -----MQLHIRGER-------TTVVESHEN-ETIADLKKKIVELKCAA-NIDFNLYCSGL --LLQN-DSL-VGDLTS--NVLELTVSLPGGKVHGSLARAGKVKAQTPKVEKQEKSK-KK TGRAKRRIQYNRRFVNVVQ-TYSRRRGPNANSNS------- >Tribolium MSHRKFSVSRHGSMGFYPKKRSQRHRGKVKAFPKDDPSKPVHLTAFIGYKAGMTHVVREA DRPGSKINKKEIVEAVTILETPPMMIVGVVGYIETPHGLRALATIWAEHLSEDCRRRFYK NWYKSKKKAFTKASKKWNDDLGKKSIERDFKKIIKYCKVVRVIAHTQMKLLNQRQKKAHI MEIQLNGGSVVDKVQWAREHLEKPIPVAQVFAQDEMIDCIGVTKGKGYKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVSFTVARAGQKGYHHRTEMNKKIYRIGAGIHTKDGKVIK NNASTEYDLTEKTITPMGGFPHYGEVNNDFIMIKGCCMGPKKRVITLRKSLLVHTKRVAL EKINLKFIDTSSKFGHGRFQTAADKAAFMGPLKKDRIKEEEKAAPTASS----------- ----------------------MAP----TAKAAKQEKKPDD----KKKSSKPRNYDLGN GVMRFSRTRMYHKK-----ALYKFMGKKVKATKKPAKPAFVTKQIGGD-KNGKERKVFLK KRRNYYPTQDKIRKHPAKK---TFKQHKRHLRSTLTPGTVCILLAGSHKGKRVVFLKQLH -SGLLLVTGPMQINSCPLRRISQRYVIGTQTKIDVSGVKIPETINDEYFRRKRE-KRAKK E---EG-DIFQ-AKKEAYKVSDQRKADQKVVDKQVFEAIKKHPDRKVLLAYLSAMFGLRS SQYPHRMQFMGRVIRAQRKGAGSVFKSHTNRRKGAPKLRYLDFSERHGYIKGVVKDIIHD PGRGAPLAVVHFRDPYKFQTRKELFIAPEGMYTGQFVYCGKKANLQIGNVLPIGSMPEGT IVCNLEEKTGDRGRLARASGNYATVIAHNHDTKKTRVKLPSGAKKVVPSNNRAMVGIVAG GGRIDKPILKAGRAYHKYKVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTSA GRKVGLIAARRTGLIRGGKVES---KKDD-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGKKKATVDDFPLCVHLVSDEYEQLSSEALEAGRICANKYLVKNCGKDQFHIRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVNIGQPIMSVRSSDRFKAQVIE ALRRAKFKFPGRQKIYVSKKFGFTKYDREVYDKLKEQGRLAPDGCNVRYRPEHGPLDAWK KVQEELLTV-------------------------------------MAPVAKGAKKEKRE VKDKSKNVMRDLHIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILERGLKVREYELRRDNFSASGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFNVAHRRRKQGKVGFPHRLTKEDAMKWFQQKYDGIILASKK---- --------MPPKFDPNEVKLVYLRCVGGEVGATSSLAPKIGPLGLSPKKVGDDIAKGTAD WKGLKITVQLKIQNRQATISVVPSAASLIIKALKEPPRDRKKQKNIKHSGNITLDDVISI ARQMRPRSMAKNLSGTVKEVLGTAQSVGCTIDGKLPHDVIDEVNDGSVEIPEEMGR--YA REPDNAAKSCKARGSNLRVHFKNTCETANAIKKMPLKRAVAYLKNVLAQKECVPFRKFNG GVGRCAQAKQWGTTQGRWPKKSAEFLLQLLRNAESNADYSGLDVDRLVVEHIQVNRAACL RRRTYRAHGRINPYMSSPCHIELWLTEGESVA---------EP-PKKVG-KKKTVEKSKK SKXXXXMGKIMKPGKVVLVLAGRYAGRKAIVVKNNDEGSGDKQYGHAIVAGIDRYPRKVH KRMGKGKIHKRSKIKPFVKVLNYNHLMPTRYSV-DLTSDVKITPKD-LKDPMKRKKVRFQ TRVKFEERYKSGKNKWFFQKLRFMA----KQKGEKSRKSAINEVVTREYTVNLHKRLHGI SFKKRAPRAIKEIRKFAEQQMGTPDVRIDTRLNKQLWSKGIRNVPFRVRVRLSRRRNDDE DSVNKLFTLVTYVPVGTFKGLQTENVDASQEMVQRLVFRRRLSYNTKSNRRHIVRTPGGR LVYQYLKKPKKIPR--CGQCKDKLRGILPARSQERSRLCRRKKTVKRAYGGVLCHKCVKE KIVRAFLIEEQKIVVKVLKAQQAVKTKK-------------------------------- ----------------MPRELHEIKQFLLTARRKDAKSVKIKKNPENT-KFKVRCSRFLY TLVIT-DKEKAEKLKQSLPPGLQVKEVKMSAHKTFIIKRKLAKKLKQNRPIPQWVRMRTG NTIRYNAKRRHWRRTKLKL----M-T--STAELACVYSALILADDDIAVTGEKIQTILKA ANVD-VEPYWPGLFAKSLEGVNIKELITKIG-SGVG-AAPAAAASAA-APAAAAXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMAVGKNKGLSKGGKKGVKKKIVDPFT RKDWYDVKAPSMFATRQVGKTLVNRTQGTKIASEGLKGRVFEVSLA-DLQNDNDAERSFR KFRLIAEDVQGRNVLTNFHGMDLTTDKLRSMVKKWQTLIEASADVKTTDGYLLRVFCIGF TNKDQLSQRKTCYAQHTQVRGIR-KKMVEIITRDITGSDLKEVVNKLLPDSIAKDIEKAC QGIYPLHDVYIRKVKVLKKPRFELSKLLELHGDGGKGGSGEPGEAGAK------VDRP-- EGYEPPVQESVMA-RGPKKHL-KRLNAPKAWMLDKLGGVFAPRPSTGPHKLRESLPLVIF LRNRLKYALTNSEVTKIVMQRLIKVDGKVRTDPNYPAGFMDVVTIEKTGEFFRLIYDVKG RFTIHRITGEEAKYKLCKVKKVQTGPKGIPFLVTRDGRTIRYPDPMIKVNDTIQLEIATS KILDFIKFESGNLCMITGGRNLGRVGTVVSRERHPGSFDIVHIKDANGHTFATRLNNVFI IGKGSKPYVSLPRG-KGVKLSIAEERDKRLAAKTQ------------------------M VDDYDEIQAGAIAAPQMAEMPEIKLFGRWSCDDVQVPDMSLQDYIAVKEKNAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAFEIIHLLTGDNPLEVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELMNAAKGSSNSYAIKKKDELERVAKSNR-----------M--SS--KIIKSGGGDPDQ FETQVAQALLELEMNSDLKAQLRELHITKAKEIELNN-KKSVIIYVPMPKLKQFQ-KIQT RLVRELEKKFSGKHVVFVGERKILPKPTRKTRTK-NKQKRPRSRTLTAVYDAILEDLVYP AEIVGKRIRVRLDGSQLIKVHLDKNQQTTIEHKVDTFASVYKKLTGREVTFEFP-EPYL- -MVNGRIPTVCSKTYVTPRRPYEKARLDQELKIIGEYGLRNKREVWRVKYTLAKIRKAAR ELLTLEEKDPKRLFEGNALLRRLVRIGVLDENRMKLDYVLGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLKSPFGGGRPGRVKRKNL RKGAGGGG-GG-EEEEDMLMPKKNRIAIYEYLFKEGVMVAKKDTHAPKHPELES--IPNL QVIKALQSLKSKGYVKEQFAWRHYYWYLTNNGIEYLRTILHLPPEIVPSTLKRQARTETT RARPTPFK-----SETSS-KPAEDRAGYRRTPGGPG---SDKKADVGAGTAD-LEFRG-G F-GRGKA-----------PQ--------M-SDVEVDD------TPVAPPATGGAMDVNQA LQEVLKTAMIHDGIVHGLHEAAKALDKRQAVLCVLAENCDEPMYKKLVSALCSEHNIPLI KVDNNKKLGEWSGLCKIDNTGKARKVVGCSCVVIRDYGEESPALDVLKEYLKNAK----- -------MADKADEQV----KKKRTFKKFTYRGVDLDQLLDLPNEQLMELMHCRARRRFS RGLKRKPMALVKKLRKAKKEAPPLEKPEIVKTHLRNMIIVPEMVGSIVGVYNGKAFTQVE IKPEMIGHYLGEFSLTYKPVKHGRPGIGATHSSRFIPLKMNPSLSKPKKE--PIHSVQVF GRKKSATAVAYCKRGKGILRVNGRPLSQVEPKMLQDKLQEPILLLGKDKFSAVDIRVRVN GGGHVSQIYAIRQAISKALVAYYQKYVDEASKKELKDILIQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASKVIIEKYYTRLTLDFHTNKRICEEIAIIP TKPLRNKIAGFVTHLMKRLRHSQVRGISIKLQEEERERRDNFVPEVSALEH-DIIEVDPE TKEMLKMLDFNNISGLQLTQPTANTFNRRA-----------------------------M ASAI-KEVNPEKP--GQDAPP----IHHIRITLTSRNVRSLEKVCSDLIDAAKKQKLRVK GPVRMPTKILRITTRKTPCGEGSKTWDRFQMRIHKRVIDLHSPSEIVKQITSINIEPGVE VEVTIADA--MG--KPRGLRTARKHVNHRREQRWADKDYKKAHLGTRWKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNHIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYSTPKKIKHKKKKVKLA VLKFYKVDENGKIHRLRRECPGEQCGAGVFMAAMEDRHYCGKCGYTLVFAKPEDK----- -----MQLCFRGLT-------THVLECQSN-ETIAEIKDRIAALENLN-SSEISLYASGV --PVAD-ASL-VSEFEN--TDIELTVGLLGGKVHGSLARAGKVKGQTPKVEKQEKKK-KK TGRAKRRIQYNRRFVNVVA-TFGRRRGPNSNAGAS------ >Callinectes MSHRKFSAPRHGSMAFYPKKRSSRHRPKVKAFPKDDRTKPVHLTAFLGYKAGMTHVVRVA DKPGSKTNRKEVVEGVTILETPPMVCVGVVGYINTPRGMRAFKTVWAEHLSEECKRRFYK NWHKSKKKAFTNATQKWQDQVGKKVIEKDLAKMKKYCSAVRIIAHTQIKILKKRQKKAHI MEIQLNGGTIADKIDWAVSHFEKQVPVENVFAQDEMVDVIGVTXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---- ------------------------------------------------------------ MVQTKTVRRSVK-----PGGVRFGKPKRKNIKVAEKPKTFVEKPIGGE-KNGGTRKVRVK KLPAYYASQPNPKKR-AKR----IKRHTKPLRSSLTPGTICILLAGIHKGKKVVFLKQLK -SGLCLVTGPFKINACPLRRVNQIFLIATATKLDISAFGTPKHINDKYFRRIKA-KRPKK E---EG-DIFE-QKQEKYVPSAQRKKDQAVVDGMVMSVIRKREDKKMLFGYLGTTFGLRN KMYPHRLKFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYCKNKPYPKSRFCRGVPDAK IRIFDLGRKKADVREMPLCVHLVSDEYEQLSSEALEAGRICANKYLVKNCGKDQFHVRVR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVQIGQPIMSVRTHDRHKAHVIE ALRRAKFKYPGRQKIYVSRKWGFTKFDRDVYEELMSKGRLFPDGVSVQYRPEHGPLAVWK RSQLELAGQI-------------------------------------------------M PGEKHKNPMREVRIGKLCLNICVGESGDKLTRAAKVLESLTGQKPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVREYELRRDNFSQNGNFGFGIQEHIDLGIKYDPAI GIFGLDFFVVLQRPGYRVAKRRRCPGKIGPQHCLVKEDAIKWFQTKYEGVILPGKKK--- --------MPPKFDPTEIKTVCLRCVGGEMAATSSLAPKIGPLGLSPKKVGDDIMKATGD WKGLKVTVKLIIQNRQARVEVVPSAASLVIKALKEPPRDRKKVKHIKHNGNLTLDQMLEI ARTMRPRSQARQLSGTLKEVLGTAQSIGCTVEGQNPHDVIEGIDDGSVEVPEEXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXX----M-A--SNDELACVYASLILMDDEVPITAEKISTILKA ANVS-VEPYWPGMFAKAAAGLDLRAMVSNVG-SGVGSGGGAVAAA----PAAAA-AAA-- --PAAEAKKEE----KEE-SEE-SDDDMGFSLFGMAVGKNKGLNKSGKKGSKKKVIDPFT RKDWYDVKSPALFFNRNVGKTLVNRTQGTKIASEGLKNRVFEVSLA-DLQNETDAERSFR KFRLIAEEVQGKNVLCNFHGFNLTTDKLRSMVKKWQTCIEANADVKTTDGYILRVFCIGF TEKVSSQTRKTAYAQHTQVKNIR-KKMVDIITRAVASSELKEVVNKLIPDSMADDIRKAC NLIYPLKEVHIRKVKVLKKPRFDLGKLLEMHGESGKS----------------------- -----------MA-RGPKHHL-KRLVAPKSWMLDKLGGVYAPRPSTGPHRLRECLPLVIL LRNRLKYALTNTEVMKITMQRLIRVDGKIRTDRNFPTGFMDVVSIKKTGEHFRILYDVKG RFIAHRITDEEAKYKLCKVKKVSVGPKGVPFLVTSDGRTLRYPDPLVKVNDSILYDLEKS KMKDIIKFDSGNLCMITGGRNLGRVGTIVSRERHAGSFDIVHVKDAVGHTFATRLNNVFV IGKGNKAYVSLXXXXXXXXXXXXXXXXXXXXXXXXXX--------------MVEQVADFE EGGEEVVGPVQGAVVEAPELPEIKLFGKWSLDDVQLNDMSLQDYIAVKKYYAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLLAVRIVKHSFEIIHLLTGENPVQIVVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLTTGAREAAFRNIKTIAECLA DELINASRGSSNSYAIKKKDELERVAKSNR-----------MPQFVNGKITKSH--PPDE FETSIGQTLLDLEMNSELKAQLRELSITGAKQIDVGD-KKCIAIFVPVPLLRSFQ-RVQQ RLVRELEKKFSGKHVVVIAQRRILAKPTRKMKNPP-KQKRPRSRTLTCVHDNILEDLVFP AEIVGKRIRVRLDGSRLIKVHLDKAQQTNIEHKVDTFAAVYKKLTGKEVSFEFR-DTYL- -MVNHRVQLVQSKRYSTPRRPFEKPRLDQELKLVGEYGLRNKRELWIVKMFLAKIRKAAR ELLTLDEKDARRLFQGNALLRRLVRTGVLEEGRMKLDYVLGLKPEDFLERRLQTQVFKLG LAKSIHHARVLIKQGHIRVRKQVVNVPSFIVRLDSQKHIDFSLKSPFGGGRYGRVKRKNM RKGGSKAE-DG-SGEDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------ >Penaeus MSHRKFSAPRHGSMAFYPKKRCRRHRPRVKTFPKDDKSKPVHLTAFLGYKAGMTHIVRVA DKPGSKINRKEVLEAVTIIETPPMVCVGVVGYIQTPRGLRVLKTIWAEHLSEECKRRFYK NWHKSKKKAFTNAAQKWQDSLGKKMIKREIAKMKKYCTHIRIIAHTQVRILRKKFKKAHI MEIQLNGGTVSEKVDWAVNHFEKQIPIDSVFAQDEMIDVIGVTKGKGMKGVTSRWGTKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTERNKKIYRIGKGIHTKEGKVIK NNASTDYDLTEKTITPMGGFPHYGEVNQDFVMLKGCTAGPRKRVLCMRKCLYPQTKRSAM EKIDLQFIDTSSKYGHSCFQTSAEKSVFMGPLKKDKAKKLAAAQKS----------XXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXV KEKKPKQKEPLGKKPLKAGCYRIWKGKKEIIRR----KNYIVKPIGGANNGNARRVLQNK R-PAYYAAQLNKKYISKRK----PKTNFKRLRPSITPGTVCIIVAGVHKGKKVVFLKRLV -SGLCLVTGPFKINACPLRRVNQIYLIATATKLDISKVEVPKHINDRYFXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXMGRVIRAQRKGRGSVFKSHTHTRKGKPALRAIDFAERHGYLRGIIKQIIHD PGRGAPLAIVHFRDPYRYKIRKEIFLAAEGMYSGQFVYCGKKANLDVGNVIPIGSLPEGT IICNLEEKTGDRGRIARGSGNYAQVIAHNPETKKTRVKLPSGAKKVLPSANRAMIGIVAG GGRIDKPILKAGRAYHKYRVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVSRNKSA GRKVGLIAARRTGLIRGTKKDPRQNA----MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIYDLGRKKSDVREMPLCVHLVSDEYEQLSSEALEAGRICANKYLVKHCGKDQFHVRVR LHPYHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVQIGQPIMSVRTHDRHKEQVIE ALRRAKFKYPGRQKIFVSRKWGFTKFDREDFEDLLAKGRLKPDGVTVQYLPEHGPLNRWK KVQLELAGLA------------------------------------------------MT SVEKSKNVMRDVHVSKLCLNICVGESGDKLTRAAKVLESLTGQKPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVREYELRRDNFSANGNFGFGIQEHIDLGIKYDPSI GIFGLDFYVVLQRPGYRVAKRRHSPGRIGPQHCLHKEDAIKWFQTKYEGIILPGKKK--- --------XXXXXXXXXXXXXXXXXXXXXMAATSSLAPKIGPLGLSPKKVGDDIMKATGD WKGLKVTVKLIIQNRQARVEVVPSAASLVIKALKEPPRDRKKVKHIKHNGNLTLDQMIDI ARTMRPRSQAKALSGTLKEVLGSAQSVGCTVEGQNPHDIIEGINDGSVEVPEEMVR--YS TDPENTTKSARAKGSNLRCSFKNTCETANNIKKMPLSRAVRYLKNVIRKKECVPFRVFNG GVGRCAQAKAWKTTQGRWPKKSARFLLDLLRNAESNAQYKGLEVEQLVIEHILVQRARQM RRRTYRAHGRINPFMSSPCHIEVILAEKEQVVSKA---QDE-PIKKKVS-KKK-LARQK- LMAAREMVXXFKPGRVVIMLGGRHTGKKGIVVKTNEEGTRDRPFEHALVVGIDRYPRRVK KSMSKSKIARRSTLKPFIRIVNLKHMMPTRYTTTDIVFNKDKVNKEVLKDPGRRQKLRQV VKAQLEERYKTGRNRWLFQKLRFM-----PRRKTEKRQSAIDKVVTREYTINLHARLHGV SFKRKATRAIKEIRKFAKQQMNTDDVRIDLRLNKFIWSRGIRNPPFRVRVRLSRRRNEDE ESSRPFYTLATLVPVASFKGLGTENVDEGSEMV-RLTLRRRLSYNTASNKRRIVRTPGGR LVYQYVKKRGKRAA--CGNCKRELAGVVRCRPYELKRMPKYKKKVSRAYGGSLCHTCVRE RVVRAFLIEEQKIVVKVLKAQKAAAAAAGGSKK--------------------------- ----------------MPRQIMEIKDFLLTARRKDARSVRIKKNKHNV-KFKVRCSRFLY TLVIR-DREKAEKLKQSLPPGLQVKESKMAAHKTFRIKTKLAKKMKQNRPIPPWIRNRTG NKIRYNAKRRHWRRTKLKL----M-A--SNDELACVYAALILMDDEVPITVEKINTILKA ASVN-VEPYWPGLFAKAVSGLDIKALVANVG-SGVGSGGGGGGGAA---PAAAA-ASSA- --PAAEAKKEE----KEEEAEE-SDDDMGFSLFGMAVGKNKGLNKSGKKGSKKRVVDPFT RKDWYDVKSPALFTNRNVGKTLVNRTQGTKIASEGLKSRVFEVSLA-DLQNETDAERSFR KFRLIAEEVQGKNVLCNFHGFSLTTDKMRSMVKKWQTLIEGNTDVKTTDGYLLRVFCVAF TEKMASQTKKTAYAQHMQVKNIR-RKMVDIITREVASSELKEVVNKLIPDTMADDIRKAC NSIYPLKDVHIRKVKVLKKPRFDLGKLLEMHGESGKAIASGEDVGSR-------VDRP-- DNYEPPVQASVMV-RGPKHHC-KRVCAPKSWLLDKLGGVFAPRPSTGPHKRRECLPLVIL LRNRLKYALTNDEVKKITMQRLIRVDGKIRTDKNYPTGFMDVVSIQKTGEHFRILYDVKG RFIAHRITDEEAKYKLCKVTKVCVGPKKVPYLTTSDGRTLRYPDPIIKINDSILFDLEKK KMKDLIKFDTGNLCMITSGCNMGRVGTIVSRERHAGSFDIVHVKDSVGHTFATRLNNVFV IGKSTKAYISLPRG-KGVKLSIAEERDRSWLRRLTK------------------------ MVDFEDGQGAPKGEVEAPELPEIKLFGKWSLDEVQLSDMSLQDYIAVKKYYAKYLPHSAG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHSFEIIHLLTGENPVQVVVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLTTGAREASFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MPQFCNGKITKQSADQPDE FETSIGQTLLDLEMNSELKAQLRELTITGATQIDVGD-KKCIAIFVPVPLLKAFQ-RVQQ RLVRELEKKFSGKHVVVIAQRRVVAKPSRKMKNPP-KQKRPRSRTLTAVHEAILEDLVYP AEIVGKRIRIRLDGTRLIKVHLDKAQQTNIEHKVETFAAVYKKLTGKVVTFEFR-EAYL- -XVNHRLKRVQSKRYSTPRRPYEKSRLDQELKLLGEYGLRNKRELWIVKMLLAKIRKAAR ELLTLDEKDPRRLFQGNALLRRLVRTGVLEESRMKLDYVLGLKNEDFLERRLQTQVFKLG LAKSIHHARVLIKQGHIRVRKQVVNVPSFIVRLDSQKHIDFSLKSPFGGGRPGRVKRKNL RKGSGKAD-DG-DGESDMLMPKANRVAIYEYLFKEGVMVAECDLFLPKHPALEKS-IPNL HVIKALQSLKSRGYVEQNFAWRHYYWRLTNEGIQYLREYLHLPSEIVPATLKKPTRPE-G RPRP-IHP----RPEGP--RSEGSREAYRRAPPGA-----DKTGDAGAGSAS-MEFRA-G F-GRGKK-----------PQ--------M-SDVEGDVGVPS--------GAGGPMDLNTA VQEVLKHALMADGLARGLHEAVKALDKRQALLCLLANNCDEPGYSKLVEALCQEHQIRLL KVDSNKMLGEWTGLCKIDREGKARKVVGCSCVVVTDYGKETQAHDVVNEYFKSKGQ---- -------MTDADVQAQIEA-RKKRIFRKFTYRGVDLDQLLDMSNEQLVELFPARQRRRFR RGLKRKHLALLKRLRKAKKECPALEKPAVVKTHLRDMIIVPEMVGSMVGVYNGKTFNQVE IKPEMISHYLAEFSITYKPVKHGRPGIGATHSSRFIPLKMAPKET--------IPSVQVY GRKKTATAVAHCKRGNGLIKVNGRPLELVEPRTLQYKLLEPVLLLGKKRFSKVTIRVRVK GGGHTSQVYAIRQAISKSLVAYYQKFVDEASKKEIKNILINYDRSLLVADPRRCESKKFG GPGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRICEEIAIIP SKPLRNKIAGFVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALEE-DIIEVDAD TKELLKTMDFDKLAGLQVTQPVPSSIGGRR-----------------------------M AMY---DKSDMKGGMMDDAAP----IHRIRITLTSSNVKSLEKVCSELVRGAKDKQLKVK GPVRMPTKILRITTRKTPCGEGSKTWDRFQMRIHKRVIDLHSPSEVVKQITSISIEPDVD VEVTIAE---MG--KPRGIRTARKHVNHRREQRWHDKDYKKAHLGTRWKANPFGGASHAK GIVLEKIGIEAKQPNSAIRKCVRVQLIKNGKKISAFVPRDGCLNFIEENDEVLVSGFGRK GHAVGDIPGIRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYTTPKKIKHKHKKVKLA VLKYYKVDDNGKITRQRRECPSDECGAGVFMANMFDRQYCGRCHLTFVFNKPE------- -----MQIFVRSEV-------THVVENAEQ-QTVGDVRSFICQAEGLP-ETEVRLYAAGS --PLDN-DSFPLANLNT--DAIDVNVALKGGKVHGSLSRAGKVKGQTPKVEKKEKRK-SK TGRAKRRIQYNRRFVNVVA-SFGKKRGPNSNS--------- >Daphnia MSHRKFSAPRHGSMGFYPKKRCRSHRGRVKSFPRDDHKKPIHLTAFLAYKAGMTHIVREC DKPGSKVNKKEVVEAVTILETPPMVIVGIVGYVATPKGLRALKTVWAEHIGEDCRRRFYK NWYKSKKKAFTKASKKWQDDLGKKVIEKELRAMKRYCKVIRVIAHTQMKLLRQCQKKAHM MEXQVNGGTVRRKVDWARQHLEKSVPITSIFAQDEMIDVIGVTKGKGFKGVTSRWHTRKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEMNKKIYRIGKGIHTRKGKVIK NNASTEYALTDKSITPMGGFPHYGEVNNDFVMIKGCCMGPKKRVITLRKALVTSAKRVAL EKIELKFIDTSSKFGHGRFQTPADKAQFMGPTKKSKTPAAAAAATPAAPAKA-------- ------------------------------------MEVSKKKPAAGVPAAKEPAPTLAS GKYTFSKSEALRRYL----SRKQARSGKRVSKAKRDEQKKKPKFVEKP-FNKGTRIVSLK KRPNNYPCKNHSKPRSKVP----KKHGATKVRKSLQPGTILILLAGVHRGKRVVLLKALK -SGLLLVTGPYKINRVPIRRVHQKFVIATSTRLNIESVKIPDTINDAYFRRIRE-KRAKK A---EG-DIFA-KKKKTYKVSATRKADQITVDKQLLRAIRPHPDRKILLNYLKSRFGLST GQYPHTLKFMGRVIRAQRKGAGGIFKSHTKHRKGAPKFRPEDFAERHGYIKGVVKDIIHD PGRGAPLAVVHFRDPYRYKTRKENFLAVEGMYTGQFIYCGKKATLQIGNVLPVGTMPEGT IVCNVEEQHGDRGTLARTSGNYATVIGHNTDTKKTRVKLPSGAKKVVSSNNRAMVGIVAX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYCKNKPYPKSRFCRGVPDAK IRIFDLGRKKASVEDFPLCVHLVSDEYEQLSSEALEAGRICANKYLVKHCGKDAFHIRMR VHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVNIGQPIMSIRSSDKYKAAVIE SLRRAKFKFPGRQKIYVSKKWGFTKFERGVYETMKENAQLEPDGANVKYRPDHGPLAAWY KWRTIFSQQ-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXR RNEKSAVHCTVRGAKAEEILERGLKVREYELRKENFSDTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFSVAERRRKTGKVGFQHRLKREDAMKWFQQKYDGIILPTKKA--- --------MPPKFDPSEVKIIYLRAVGGEIGATSSLAPKIGPLGLSPKKVGEDIAKGTQD WKGLKITVQLTIQNRQAAVSVVPSASSLVIKALKEPPRDRKKQKNIKHNGNITFDEVISI ARIMRTRSQSRYLIGTVKEILGTCMSVGCTIDGRTPRDITDAVTNGELEVPEEMGR--YS REPDNPTKSCKARGSNLRVHFKNTREAANTIKRMPLKRAVAFLKNVIQHKECVPFRRYNG GVGRCAQAKQWGTTQGRWPKKSAEFLLQLLKNAESNADLKGLDVDHLVIDHIQINRAPYM RRRTYRAHGRINPYMSSPCHMEVILAEKEDIVSKV---KEEE-----VTNKKK-VSKKK- LAR---MGKIMKSGKVVLVLGGRFAGRKAIIVKNYDEGTSEKPYGHALVAGVDRYPRKVT NKMSKKKVAKRSKIKAFVKIVNYNHMMPTRYSV-DLSFDKNLVNKDSIKDPLKRKKARFA VRTKFEERYKSGKNRWFFSKLRFMA----KEKREKTRKSAINEVVTRDYTVNLHKRIHGI SFKRRAPRAIKEIRKFAEQAMGTPDVRIETRLNKHIWSQGVRSVPFRVRVRLSRRRNEDE DSPHKLYTLVSFIPVATFKGLQTENQEVSEDMAQRLTYRRRLSYNTASNQRRIVRTPGGR LVYQYKKKQRKIPK--CGMCKTTLRGIRPARAHERKRMSLRQKKVYRAYGGCLCHSCVRE KIVRAFLIEEQKIVAKVLKAQQAAVKSSKGKV---------------------------- ----------------MPKQIMEIKDFLLKARRKDAKSVKIKKNPENT-KFKVRCSRFLY TLVIT-DKEKAEKLKQSLPPGLQVKELKMGAHKTLKVKKLLAKKMKQNRPIPQWIRLRTD NTIRYNAKRRHWRRKKLKLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMAVGKNKGLSKGGKKGLKKKIIDPFT RKDWYDIKAPSMFAVRQVGKTLVNRTQGTRIASEGLKGRVFEVSLT-DLQNESDSERAFR KFKLISEDVQGRNLLTNFHGMDMTTDKLRSMVKKWQSLIEASVEVRTTDGYLLRVFCIGF TKKEAESTRKTCYAQHAQIKSIR-KKMVDIITREVGSVDLKEVVSKLIPDSISKDIEKSC QGIYPLHDVNIRKVKVLKKPKFDIGKLLELHGDGGKSGVGGEGGVSGS------VDRP-- EGYEPPVQESVMA-RGPKKHL-KRLAAPKSWMLDKLGGVFAPRPSTGPHKLRESLPLVVF LRNRLKYALNNSEVTKIVMQRLIKVDGKVRTDSNYPAGFMDVITIDKTGEYFRLVYDVKG RFAIHRITAEEAKYKLCKVRRVQVGPKGIPFITTHDGRTIRYPDPLVKVNDTIQLDIETN KIMDFIKFDSGNLCMITGGRNLGRVGTIINRERHPGSFDIVHVKDALGHLFATRLNNVFI IGKGSKAYISLPRD-KGVKLSIAEERNKRLAAKAAA----------------------MA DDGHEEQAVVVAAPPPMAELPEIKLFGRWSCDDVQISDMSLQDYLAVKEKYAKFLPHSAG RYAAKRFRKAQCPIVERVTNSLMMHGRNNGKKLMAVRILKHSFEIIHLLTSENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MLSAS--KIIKPAGEKADE FENSIAHALLDLELNSDLKAQLRELHINAAKEVDVGG-KKAVIIFVPVPQLRAFQ-KIQT RLVRELEKKFSGKHVVFIAQRRILPKPTRKTKLRI-KQKRPFSRTLTSVHDSILEDLVFP AEIVGKRIRIRLDATRLIKVHLDKNQQTNIEHKVETFAAIYKRLTGKEVTFEFP-EAYL- -MVNHRAPLVQRKVCVAPRRPFEKARLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAAR ELLTLDEKDGKRLFEGNALLRRLVRIGVLEESRMKLDYVLSLKVXDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQLVNIPSFIVRLDSQKHIDFALRSPFGGGRAGRVKRKNL KKGTDGGD-GG-EEDDEMLMPKRHRALIYEYLFKEGVLVAMKDTHLAKHPEID---VPNL HVMKALQSLKSRAYVTEQFAWRHYYWYLTNEGIQYLRDYLHLPPEIVPATLK-PKRTESA RPRAAAAT----RPEAS--KMSEDRSAYRRSAPAGG----DKKADVGAGANPNLEFRG-G Y-GRGRGSA---------P---------M-SDMEGGDVLS-------APVAGGPLDINTA TQEVLKNAMIHDGLARGLHEAAKALDKRQALLCVLADNCSEPMYKKLVTALCQEHNIPLM KVDNNKKLGEWAGLCKIDKEGKARKVVGCSCVAVKDWGIETEATAVVLDYLKKQ------ -------MADAEDQT-----KKKRTFRKFTFRGVDLDQLLDMSMDQLLEMLSSRVRRRFR RGLKRKHMALLKKLRGAKKEASENEKPAVVKTHLRNMIIVPEMVGSIVGVYNGKVFNSVE VKPEMIGHHLGEFSICYKPVKHGRPGIGATHSSRFIPLKMTAPTTTSTAPKEPIQSVQVF GRKKTATAVAYCKRGHGLIKVNGRPLSIIEPRLLQYKLYEPILLLGKDRFAGVDIRIRVK GGGHVAQVYAIRQAIAKSLVAYYQKYVDEASKQEIKDILINYDRSLLVSDPRRCEAKKFG GPGARARYQKSYRMALLKMGRVRTKTVKKAAKLIIEKYYTRLTLDFHTNKRICEEIAIIP SKPLRNKIAGFVTHLMKRLQHKTVRGISIKLQEEERERRDNYVPEQSVLDM-DTIEIDSE TKEMLKMLELEKIPKLHVVNPTPTGHTGGHGGHPHGGQRR-------------------M AY-----KDTGK--PVAEEAV----IHKIRITLTSRNVPSLEKVCSELVGAAKDKNLRVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRIIDLQSPAEIVKQITSFSIEPGVE VEVTIADA--MG--KPRGLRTARKHVNHRREQRWHDKEYKKAHLGTRWKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLTFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSAKKRKKKNYTTPKKNKHKHKKVKLA VLKYYKVDENGKINRLRRECPGEKCGAGVFMAAHKDRQYCGKCAKTFVFNAPESDE---- -----MQLTIRGQN-------THLLECTGS-ESIAELKSKIAVLENLP-VSELRLFSVGA --PLAD-EIN-ISTLTS--ATVDVTVPLLGGKVHGSLARAGKVKHQTPKVDKQEKKK-KK TGRAKRRVQYNRRFVNVVP-TFGRKKGPNANAA-------- >Acanthoscurria XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPVHLTAFIGYKAGLTHIVREV DKPGSKVNKKEVVEAVTILETPPMMIVGVVGYIETPKGLRAFKTIWAEHLSEDCRRRFYK NWYKSRRKAFTKYAKKWQDDIGKKEIEKDFSKMAKYCKVIRVIAHTQMKLMRKRQKKAHI MEIQLNGGTINQKIRWAREHLEKPVPLSQVFTQDEMIDCIGVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------- -------------------------------------MCKKGEGKEGKRTRPPRNRKLPG GIWRFSRSQMYHRR-----GMFKIKKQTVKKEKPKRKPRSVVKPIGGE-KNGGKRLVKLK KQRRYYPTEDKPRLKKSRK-MVPFNKHKRYLRKRITPGTVLILLAGRHRGKRVVFLKQLD -TGLLLVTGPYRVNGCPLRRINQIYVIATSTKVDISNVKIPEHLDDKYFQRKKQQRKAKK D---EV-EIFE-TKKEEYVITEKRKQDQIEIDHQILEAVRAHPDRKIMFGYLRSMFYLQN KMYPHKXXXMGRVIRSQRKGAGSVFKSHTKHRKGAPKLRAVDFAERHGYIKGIVKEIIHD PGRGAPLAVVVFRDPYRYKQKKELFIAAEGMYTGQFIYCGKKAVLQVGNVLPVGTMPEGT IICNLEEKSGDRGRLARGSGNYATVISHNTDTRKTRVKLPSGAKKVLPSSNRAMVGIVAG GGRIDKPILKAGRAYHKYKAKRNSWPKVRGVAXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFHLGRKKAKVDEFPLCVHLVSKEFEQISSEALEAGRICANKFLVKTCGKDAFHLRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVKIGQVIMSVRAKEQHKENVIE ALRRAKFKFPGRQKIAVSKKWGFTKWEATDYEDMRADGRLKPDGVYCHYFNNHGPFIVWE KIQKEIRGMS--------------------------------------M-ARLAEQVAIK SSKDK-NPMREVHIRKLCLNICVGESGDRLTRAAKVLEQLTGQRPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVREYELRRENFSDTGNFGFGIQEHIDLGIKYDPTI GIYGLDFFVVLGRPGFIVAHRKRRKGTVGVKHMLTKEEAMKWFQQKYDGIILPGKK---- --------MPPKFDPTEIKIVYLRVVGGEXXATSSLAPKVGPLGLSPKKVGDDIAKATAD WKGLKITVKLVIQNRQAQIEVVPSAASLIIRALKEPPRDRKKVKHVKHSGNITFDDIITI ARTMRPRSMARKLEGTVKEILGTCQSVGCTIDGSHPHDLIKQIDSGELEVPEDMAR--YS MEPENATKSCKARGSNLRVHFKNTRETAQAVKRMPLRRAQRFLKNVIAKKEIVPFRRFNG GVGRKAQAKQWSATQGRWPKKSAEFLLQLLRNAESNADYKGLDVDRLVIEHIQVNRAPKM RRRTYRAHGRINPYMSSPCHIEVILSEKEQVVAKPST-EEEAP-KKKLS-KKK-LARQK- LTQRD-MGKIMKIGKVVLVLNGKYAGRKAVVVKNYDEGTTDKPYGHALIAGIDRYPRKVT RSMGKKKISKRSKIKPFVKVLNYNHLMPTRYMV-DIQFDKSIVNKDVLKDPGKRRKARRD VKGKFEERYKTGKSRWFFQKLRFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXMAAHKTFKIKQKLAKKMKQNRPIPQWIRMKTG NTIRYNAKRRHWRRTKLKL----M-L--STDELACVYGALILQDDDIAVTSEKISTLLKA ANVD-VESYWPGLFARALEGLDVKKLITNVG-SGVG-AAPAASSSS---PAAAAAA---- --EEKKEAKEE----KVSEPEE-SDDDMGFGLFDMAVGKNKGLAKGGKKGVKKKVVDPFT RKDWYDVKAPAMFSVRNVGKTLVNRTQGTKIASEGLKGRVFEISLA-DLQND---EIAFR KFRLIAEEVQGRNVLTNFHGMDLTTDKLRSMVKKWQTLIEANVDVKTTDGYLLRMFCIGF TKKWATQVKKTCYAQHTQVRAIR-RKMTEIMMREVSSADLKEVVNKLIPDSIGRDIEKAC QGIYPLHDVMIRKVKVLKKPKFDVGKLMELHGEGSGK--TTTTTTTKAGDEGTKIDRP-- EGYEPPVLESVMA-RGPKKHL-KRLNAPKSWMLDKLGGVFAPRPSTGPHKLRESFPLIIM LRNRLKYALTYAEVKKIVMQRLIKVDGKVRTDTNYPSGFMDVITIEKTGEYIRLLYDVKG RFILHRITAEEAKYKLCRVKRVQVGPKGIPFLVTHDGRTIRYPDPLIKVHDTIQLDIATG KIMDFIKFDIGNLVMVTGGHNLGRVGTITSRERHPGSFDIVHVKDTQGHSFATRLNYIFV IGKGNKPYISLPRG-KGVKLSAAEERDRRLAAKAQH-XXXXXXXXXXXXXXXXXXXXXXX XXXXXXTWDEPSPVPMVQEQPEIKLFGKWSSSDVQVSDISLTDYIAVKEKYARYLPHSAG RYATKRFRKAQCPIVERLTNSMMMHGRNNGKKLLAVRIVKHAFEIIHLMTNENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELMNAAKGSSNSYAIKKKDELERVAKSNR-----------MYSVGA-KIVKPHNEKPDE LENTIAQAIWELELNSDLKAQLRELHIVGAKEVDVNG-KKALVISVPVPQLKAFQ-KIQA RLVRELEKKFSGKHVVFVARRTMLPKPTRKMKVK-NKQKRPRSRTLTAVHNAILEDLVFP AEIVGKRIRIRLDGSRVMKVHLNKNQQTNIEHKTETFAAVYKKLTGKEVTFEFP-EPLF- -XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXMLMPKKDRVAIYEYLFKEGVLVAKKDFHAPKHPELEN--VPNL HVIKAMQSLKSRGYVKEQFAWRHYYWYLTNEGIQYLREKLHLPPEIVPSTLKRQAKTETT RQKA-RAP-----AEATP-RTTSDREGYRWA-PGGP----NKKGDVGVGADTKLEFKG-G F-GRGRA-----------PQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXMEDEQQQQEAL--KKKRTFRKYTYRGVDLDQLLDMSNNQLMELLHCRARRRFS RGLKRKQLALIKKLRKAKKEAGPLEKPEVVKTHLRDMVVVPEMVGSIVGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMMDGAQKEA-----IQSVQVF GRKKTATAVAYCKRGNGLIKVNGRPLDLLEPQVMKYKLLEPVLLLGKERFAGVDIRVRVK GGGHVAQIYAIRQAISKALVAYYQKYVDEASKKEIKDILIQYDRSLLVADPRRCEPKKFG GPGARARYQKSYRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXM AGY-KDMKGVEEP----QTWT----NHRIRITLTSLNVRSLEKVCTDLIRGAKEKELKVK GPVRMPTKVLRITTRKTPCGEGSKTWDRYQMRIHKRIIDLHSPSEIVRQITSISIEPGVE VEVTIADA--MG--KPRGIRTARKHRNHRRDQRWHDKDYKKAHLGTRWKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKEKKERPRSXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXMQLFLRCQG-------THAVEV-GD-EKVENLKSYVEELEQIA-QSEQVLYYCGH --PLNDDDEISQC-LVD-GATVDVCLRLRGGKVHGSLARAGKVKGQTPKVEKQEKKK-KK TGRAKRRMQFNRRFVNVVV-TFGRKKGPNSNS--------- >Rhipicephalus MSHRKFSAPRHGSMGFVPKKRSKRIRGKVKAFPKDDPTKPIHLTAFLGFKAGMTHIVREV DKPGSKVNKKEVVEPVTILETPPMMIVGVVGYIETPKGLRAFKTIWAEHLSEECRRRFYK NWYKSKKKAFTKSCKRWQEDVGRQEIERDFKKMKKYCKVIRVLAHTQMKLMHRRQKKAHI MEIQVNGGTVGAKIKWAREHMEKPVPVSQVFSQDEMIDVIGVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGFHHRTEINKKVYRIGQGVHKKDGKLVI NNAATDYDTSNKSITPMGGFPHYGVVNCDYVMLKGCIMGPKKRVITLRKSLLVHTKRTAL EKITLKFIDTSSKFGHGRFQTPAEKHNFMGPLKKDKLKEEGTA-------------XXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXMGRVIRAQRKGAGSVFRSHNKHRKGAPKLRAVDYAERHGYIKGIIKEILHD PGRGAPLARVVFRDPYRYKLKKELFLAAEGMHTGQFVYCGKKAALQVGNVLPVGAMPEGT VICNVEEKPGDRGRLARTSGNYATVIAHNADTRKTRIKLPSGAKKVLPSANRAMVGIIAG GGRVEKPILKAGRAYHKYKAKRNSWPKVRGVAMNPVEHPHGGGNHQHIGKASTVRRDASA GRKVGLIAARRTGRIRGGKVNAQG-KDD--MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKARVDEFPLCIHLISKEFEQISSEALEAGRICANKYLVKTCGKDAFHLRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQKIMSVRAKEQHKENVIE ALRRAKFKFPGRQKVHVSKKWGFTKWDAEEYEEMRADGRLKPDGCYCHYRGGHGPLNNWM KIQRELRGLE--------------------------------------MTAKTKLPRKDK KDKEK-NPMREVRIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVREYELRKDNFSDTGNFGFGIQEHIDLGIKYDPTI GIYGLDFYVVLGRPGFNVAHRRHKKGTIGCKHRLCKEEAIKWFQQKYDGIILPGKSGK-- --------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMAQRLTLRRRLSYNTNSNRRRISKTPGGK LVYLYLKKPGSVPK--CGDCKLKLRGITPARPRELSALSKRHKTVTRTYGGSRCGKCVRN RIIRAFLIEEQKIVAKVLKAKQSEEPKKASKK---------------------------- ----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPGIGKNKGLSKGGKKGVKKKIVDPFT RKDWYDVKAPAMYAVRNIGKTFVNRTQGTKIASEGLKGRVFEVSQA-DLTNG---EDAFR KFRLIAEEVQGRNVLTNFHGMDLTTDKLRSMVKKWQTLIEATVDVRTTDGYLLRMFCIGF TKKCANQLKKTCYAQHNQVRLIR-KKMTEMMIQEVSSTSLKEVVNKLIPGSIGKDIEKSC QHIYPLHDVLIRKVKVLKKPKFELGKLLELHGEGSGKGGASTTASAAKGEEGMKVDRP-- EGYEPPVL---MA-RGPKKHL-KRLNAPKSWMLDKLGGVFAPRPSTGPHKLRESLPLIIM LRNRLKYALTGAEVKKIVKQRLIKVDGKVRTDTNYPAGFMDVVTIEKTGEFFRLLYDVKG RFILHRITPEEAKYKLCRVKRVQVGPKGVPFLTTHDARTIRYPDPLIKVNDTVKVDLATG KIDDYIKFDSGNMCMVTGGHNLGSCGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXVVPTEQLETKLFGRWSSSDVQVSDIGLTDYIAVKEKHAKYLPHSSG RYASKRFRKAQCPIVERLTNSMMMHGRNNGKKLLAVKIVKHSFEIIHLLTGENPLQVVVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGARESAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MYSQNV-KIIKPQGEKVDP FEAGISQTLLELEMNSDLKAQLRELHIVEAKLVEVNG-KKAILIYVPVPQLKAYQ-RIQA RLVRELEKKYSGQYVVFLAKRNILPKPTRKTRQR---QKRPRSRTLTAVHDALLEDLVFP AEIVGKRVRVRLDGSRLIKVHLERSQQTNIEHKTDTFAAVYKKLTGKEVTLEFR-EPPY- -XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMAATTKEA------IQSVQVF GRKKTATAVAYCKRGNGLLKVNGRPLENIEPLTLRYKLLEPILLLGKERFAGVDIRIRVK GGGNVAQIYAIRQAISKALVAYYQKYVDEQSKKEIKDTLIQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASRLIIEKYYTKLTLDFHTNKRICEEIAQIP SKKLKNKIAGFVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALEQ-DVIEVDGD TMEMMKALDMAGISGLQTTPLGPFRGGQRN-----------------------------X XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXMKIIIQCQE-------SHAVEVTGD-ETVAFLKNYLHTAEGIV-PEDQRLYAEGG K-PLNDGDLLSAC-LAD-GALVNAVVPLVGGKVHGSLARAGKVKGQTPKVEKQEKKK-KK TGRAKRRIQYNRRFVNAVA-TFGRRRGPNANQAS------- >Boophilus MSHRKFSAPRHGSMGFVPKKRSKRIRGKVKAFPKDDPTKPIHLTAFLGFKAGMTHIVREV DKPGSKVNKKEVVEPVTILETPPMMIVGVVGYIETPKGLRAFKTIWAEHLSEECRRRFYK NWYKSKKKAFTKICKRWQEDAGRQEIERDFKKMKKYCKVIRVLAHTQMKLMHRRQKKAHI MEIQVNGGTVGAKIKWAREHMEKPVPVSQVFSQDEMIDVIGVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGFHHRTEINKKIYRIGQGVHKKDGKLVI NNAATDYDTSNKSITPMGGFPHYGVVNCDYVMLKGCIMGPKKRVITLRKSLLVHTKRAAL EKITLKFIDTSSKFGHGRFQTPAEKHNFMGPLKKDKLKEEGTA----------------- -------------MSGKPDPKAKKAPAAAKTAAKGASAVAKGDAAVPKKAHAPRNQKLPG GVWLFSRSKMFHKRG-----LFKVKHAPVPKEKRKRKKRVHVKKINGD-NNGGKRVVHIK KERRSYPTEDSPKHKRTTH-MKPSSLRIAKLRKRITPGTILILLAGPHRGKRVVFLKQLK -TGLLMVTGPYGINGCPLRRINQIYVIATSTKIDISSVKLPENLDDRFFNRPKSAKRRSR K--DEG-EIFD-TKPQERTVSDEHRKVQKEVDKQVLEAMKKHPEKRALVHYLAASFSLRN RMYPHRMKFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKARVDEFPLCVHLISKEFEQISSEALEAGRICANKYLVKTCGKDAFHLRMR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQKIMSVRAKEQHKENVIE ALRRAKFKFPGRQKVHVSKKWGFTKWDAEDYEEMRADGRLKPDGCYCHYRGGHGPLNNWM KIQRELRGLE--------------------------------------MTAKTKLPRKDK KDKEK-NPMREVRIRKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVREYELRKDNFSDTGNFGFGIQEHIDLGIKYDPTI GIYGLDFYVVLGRPGFNVAHRRHKKGTIGCKHRLCKEEAIKWFQQKYDGIILPGKSGK-- --------MPPKFDPTEIKVVCLRAVGGEVGATSALAPKIGPLGLSPKKVGDDIAKATQD WKGLKITVKLIIQNRQATIEVVPSAASLIIKALKEPPRDRKKVKNVKHSGNLSFDEILTI ARTMRARSMARSLSGTVKEILGTCQSVGCTVDGSHPHDVIDKVNSGDVEVPEEMGR--YS VDPDNATKSCKARGSNLRVHFKNTRETAQAIKHMPLRRAQRYLKNVIAKKEIVPFRRFNG GVGRKAQAKAFGCTQGRWPKKSAEFLWQLLRNAESNADYKGLDVDRLVIDHIQVNRAPKM RRRTYRAHGRINPYMSSPCHIEVILSEKEQVVSAPS-AEEDAP-KKKQS-KKK-MARQK- LMQRD-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXEGKREKRGKSTLNEVVTREYTIHLHKRLHGI GFKKRAPRAIKEIRKFAEKQMGTSDVRVDTRLNKFIWSKGIRSVPFRVRVRLARRRNEDE DSPNQLYTLVTYVPVESFKKLQTVNVESSDNXXXXXXLRRRLSYNTNSNRRRISKTPGGK LVYLYLKKPGSVPK--CGDCKLRLRGITPARPRELSALSKRHKTVTRTYGGSRCGKCVRN RIIRAFLIEEQKIVAKVLKAKQSEEPKKASKK---------------------------- ----------------MPKQLKEIKEFLLTARRKDAKSVKIKKNPDNVTKFKVRCSKYLY TIVVT-EKEKAEKLKQSLPPGLQVKELKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXX----M-P--SNDELACVYGALILQDDEIAVTAEKISTILKA AGVE-VEPYWPGLFAKALEGLDLKSLISNVG-SGVG-AGPAAAAA----PAAAAAGAPAA GGGKPEAKKEEK---KEE-SEE-EDDDMGFGLFDXXXXXXXXXXXXXXXXXXXXIVDPFT RKDWYDVKAPAMYSVRNIGKTFVNRTQGTKIASEGLKGRVFEVSQA-DLTNG---EDAFR KFRLIAEEVQGRNVLTNFHGMDLTTDKLRSMVKKWQTLIEATVDVRTTDGYLLRMFCIGF TKKCANQLKKTCYAQHNQVRLIR-KKMTEIMIQEVSSTSLKEVVNKLIPGSIGKDIEKNC QHIYPLHDVLIRKVKVLKKPKFELGKLLELHGEGSGKGGASATASAAKGEEGMKVDRP-- EGYEPPVLETVMS-RGPKKHL-KRLNAPKSWMLDKLGGVFAPRPSTGPHKLRESLPLIIM LRNRLKYALTGAEVKKIVKQRLIKVDGKVRTDTNYPAGFMDVVTIEKTGEFFRLLYDVKG RFILHRITPEEAKYKLCRVKRVQVGPKGVPFLTTHDARTIRYPDPLIKVNDTVKVDLATG KIDDYIKFDSGNMCMVTGGHNLGRVGIITSRERHPGSFDIVHVKDSQGHSFATRLNYIFV IGKSTKPYISLPRG-KGIKLTVAEERDRRLQLKAQH------------------------ MGDCWDDPAPATVTVVPTEQLETKLFGRWSSSDVQVSDIGLTDYIAVKEKHAKYLPHSSG RYASKRFRKAQCPIVERLTNSMMMHGRNNGKKLLAVKIVKHSFEIIHLLTGENPLQVVVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGARESAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MYSQNV-KIIKPQGEKVDP FEAGISQTLLELEMNSDLKAQLRELHIVEAKLVEVNG-KKAILIYVPVPQLKAYQ-RIQA RLVRELEKKYSGQYVVFLAKRNILPKPTRKTRQR---QKRPRSRTLTAVHDALLEDLVFP AEIVGKRVRVRLDGSRLIKVHLERSQQTNIEHKTDTFAAVYKKLTGKEVTFEFR-EPPY- ---MGRIPTVHSKTYVTPRRPFEKERLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAAR ELLTLDDKDPKRLFEGNALLRRLVRVGVLEESKMKLDYVLGLRIEDFLERRLQTQVFKHG LAKSIHHARVLIRQRHIRVRKQVVNVPSFVVRLDFEKHIDFSLKSPFGGGRPGRVKRKNM RKAQGGTA-Q-EEEDDDMLMPKKNRVAIYEYLFKEGVLVAKKDFHAPKHPELEA--IPNL QVIKALQSLKSRGYVKEQFAWRHYYWYLTNEGIQYLRDFLHLPPEIVPATLKKQSRQEAP SRRP-KMT-----QDMQS-KTTDDRSDYRRAPGL------DKKGDVGPGTDTNFDFRG-G F-GRGRGA---------P-Q--------M--EAIAASGEP--------------MDVYTA LQEVLKMALMHDGLARGLHEAAKALDKRQAHLCVLANNCDEASYVKLVEALCAEHQINLI KVDSNKKLGEWAGLCKIDKEGKARKVVGCSCVVVKDYGKETQAHDVLMDYFQSKRG---- -------MEDENQQELA---KKKRTFRKYTYRGVDLDQLLDMSSTQLMELMHCRARRRYA RGLKRKPLALIKKLRRAKKECGPLEKPEVVKTHLRDMLVVPEMVGSIVGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMAAPTKET------IQSVQVF GRKKTATAVAYCKRGNGLLKVDGRPLENIEPLTLRYKLLEPILLLGKERFAXXXXXXXXX XXGNVAQIYAIRQAISKALVAYYQKYVDEQSKKEIKDTLIQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASRLIIEKYYTKLTLDFHTNKRICEEIAQIP SKKLKNKIAGFVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALEQ-DVIEVDGD TMEMMKALDMAGISGLQTTPLGPFRGGQRN-----------------------------M S-VYKDTKPVDDS----QAWP----VHRIRITLTSRNVASLEKVCADLIKGAKDKELRVK GPVRMPTKTLRITTRKTPCGEGSKTWDRYQMRIYKRVIDLHSPSEIVKQITSISIEPGVE VEVTIADS--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAKKRKKKNYTTPKKNKHKKKKVKLA VLKFYKVDENGKITRLRRECPSEDCGAGVFMAAHFDRQYCGKCCLTYVYNKPDEK----- -----MKIIIQCQE-------SHAVEVTGD-ETVSFLKNYLHTAEGIV-PEDQRLYAEGG K-PLNDGDLLSAC-LTD-GALVNAVVPLVGGKVHGSLARAGKVKGQTPKVEKQEKKK-KK TGRAKRRIQYNRRFVNAVA-TFGRRRGPNANQAS------- >Hypsibius XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXMGRVIRGQRKGAGGIFKAHTHHRKGAPSFRTYDFAERQGYVRGVVKDIIHD PGRGAPLAVVAFRDPYRYKTRKELFIAAEGMHTGQFVYCGKKASIHVGNVLPLSSMPEGT VVCNLEHKTGDGGSLARCSGNFATVISHNPEAKISRVKLPSGSKKVINWNNRAMIGIAAG GGRIDKPILKAGRSYFKYKAKRNCWPYVRGVAMNPVDHPHGGGNHQHIGKASTVRRDISA GRKVSLIAARRTGRIRGVKVEA-G-KRDE-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIYDLGRKKALVDEFPLCVHLVSDELEQLSSEALEAGRICCNKYLVKTCGKDSFHIRMR VHPFHVLRINKMLSCAGADRLQTGMRQAYGKPLGLAARVNIGQPIMSVRAKDVHKKEVIE SLRRAKFKYPGRQKIFVSKKWGFTKFERETYEEMRANGQLMPDGVICQYLPNTVPWPHG- -----------------------------------MAAPAAKAAKKPILDNKKIVAKKEK HDLEKH-PMRQLRIVKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILDKGLKVREYELRDNCFSHNGNFGFGIQEHIDLGIKYDPGI GIYGMDFYVVLGRPGFGVVNRRRKTGHVGLNHRLNKKDGMKWFQQKYEGIILPAKTVAK- --------MPPKFDPNEIMIVYMRAIGGEIGATASLAPKIGPLGLSPKKVGEDIAKATQD WKGLKVTVKLTIQNRVAKIDVVPSAASLIIKALKEAPRDRKKVKNIKHSGNLTFDDIVDI ARTMKPRSMARKLEGVVKEILGTCQSVGCTVEGSNPHDIIEKINAKELDVPEKMGR--YS RESENPSQSCKAKGTDMRVHFKNTRETARAIKGMTLRRATAYLKNVVEKKEIIPYRRFTG HVGRKGQAKQFGATQGRWPKKSAEFLLSLLRNAESNGEYKSLNVENLVVDHIQINRAPKM RRRTYRAHGRINPFLSSPSHMEVILVEKEGVVPKPSSSAAEAPKKKKES-KKK-IARQN- AQNRE-MVKIMKGGKVVLILSGKYAGRKAVVIKNYDEGSGDKQYGHALVAGIDRYPRKVT KTMGKKKIAKRSRIKPFVKVVNYNHVMPTRYSV-DIAFEKNVVNRDAFRDQALRRKARSE VRKKFEERYKTGKNKWFFTKLRFMN----RKREGRRKKGATNEVVTREHTIHLHKRLFQV GFKKRAPRAIKEIRKFAKVQMGTEDVRVDTKLNKFVWSKGIRGVPFRVRVRLSRRRNEDE DSPHKLYTLVTWVPVEEFHGLQTNNVDNEE-MVQRLTLRRRLPYSTQSNKHKIVKTPGGR LTYIYLKKLATPAR--CGDCKRDLPGVIRARPRKLHSVSKRQKHVTRTYGGSRCHFCVRT RIIRAFLIEEQKIVQRVLKAKEGTVKRA-------------------------------- ----------------MPKQVKEIKEFLLLARRVDAKVVKIKKQKEYV-KFKIRCSRFLY TLKLD-DKEKADKLRASLPPGVQVKDVXMSSHKTFKIKQKLAKAFKMNRPIPQWVRLQTG NKIRYNAKRRHWRRTKLGL----M-S--TKEELACVYAALVLLDDDVAITGDKIATLLKA ANID-VEPYWPDLFARSLEGVSLKELISSFG-A----AAPAAAAA----PVAAAAAPAAK EEPAKGGKKEEKKPAKEE--EG-SDDDMGMSLFDMAVGKNKRLSK-GKKGSKKKIVDPFS KKDWYDVKAPSNFNVRTIGKTVVSRTVGTKIASDGLKGRVFELAQA-DLNND---EVSFR KFKLVAEDVQGRNVITNFHGMSMTTDKLRSLMKKWRTCIEGHVDVKTTDGYLLRFFAIGF TKKRNNSIKKTCYAKSSLVKAIR-KKMVDIITREVAEKDLKDVVNKLLPDSMGADIEKSC QNIYPLQDCHIRKVKCLKKPKFDLHKLMEMHESSGTATTTTG--TAG-G---VVIDRP-- DNFEPPVLDSVMA-RGPKKHL-KRLNAPKHWMLDKLGGVFAPRPSCGPHKLRESLPLIIF LRNRLNYALTGDEVKKILMQRLIKVDGKVRVDPTYPAGFMDVISIEKTNENFRLIYDTKG RYAVHRIQAEESKYKLCRAKSLGVGPKGVPFLVTSDGRTIRYPDPAIKISDTIQLDIATS KIIDFIKFEVGNLCMITGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------MADENWTADDA AVGGEEGDQYNVVGVADEPAGEVKLFGKWSTSDVVISDISLTDYIAVKEKHAKFLPHSAG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHTLEIIHLLSGENPVQTVVS AVINAGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGARESAFRNIKTIAECLA DEIINASKGSXXXXXXXXXXXXXXXXXXXXMAASPAKKHQQVASRHEGKFVKPGGEKLTT FEQQISQFLVDLESSQDLKGSLQELFVNEAKEMEVGG-KNIIVLYVPPPQLRAWQ-KTHV RVVRELEKKLGGRPVIFIAKRRMLPKPTRKTIKL--SQKRPRSRTLTAVHENMLADIVFP AEIVGKRTRVKQDGSRLLKIHLDKASQVNVEHKVEVFASLYKKLTGKGVSFXXXXXXXXX X--MVRVPIVYSKCYSTPRRPFEKERLDQELKLIGEYGLRNKREVWRVRYTLAKMRKAAR ELLTLEEKDSRRLFEGNALLRRLVRIGVLDEQQMKLDYVLGLKLENFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVTVPSFIVRLDSQKHIDFSLQSPFGGGRPGRVKRRNA KKGKEDTT-GGDDAGDDMLMPKSQIRDIYEYLFMEGVLVAKKDVHLAKHPLIPS--IPNL HVMKCLNSLKSRGYVKEQFAWRHLYWYLTNEGIEFIRDYLNLPEEIVPNTMKPKQRAE-- -TQRAKPLA---RPDYRS-DQGGDRDVYRKAA--------EKKGDLGLGPNQDIEFRG-G FQGYGRGQPR---------QMSDTEERDDTIGDEGADADASIQPPPGGAVPEAKMDLTQA LQEVLKRALIEDGLARGIHECAKALDKRQALMCVLAKNCDEPMYVKLVEALCKEHGINLI RVDDNKKLGEWVGLCKIDKEGKPRKVVRCSCVVVKDYGKQTPAHEMLQKYFKSQRGGGEA SDTEDNDMADQIDAEEL---KKKRQFRKFAYRGVDLEQLLTLNLQEVTKLLPCRARRVIR RGAKHKKSALMKKLRNAKKNAPVNEKPEVVKTHLRNAIILPEMIGCVVGIHNGKVYNQVE IKPEMIGHYLGEFSMTYKPVKHGRPGIGATHSSRFIPLKMSAPPKQAK---PVIQAVQVF GRKKTATAVAYCKRGRGAIRVNGRPLELLEPQSLKYKLLEPIQLLGKTRFSGVDIRVRVK GGGNVAQIYAIRQAISKGLVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASRHIIEKYYTKLTLDFHTNKKVIEEVAVLP TKKLRNKVAGFITHLMKRIQKAPVRGISIKLQEEERERRDNYVPEISVLDAQDVIDVDPD TKEMLVKLLGFPSKMPNINVAAASTEPGGAFRQPQRPERGERRQFGGEGQGGAAGAAAHM AATSQHPQEELKE--GKEEAVHGGDTRKIRITLTSTNVASLEKVCAEFVQKSKEKKVKTK GPVRIPTKVLRITTRKTPCGEGSKTWDRFQMRIHKRVIDLFSVPETVKQITSISIEPGVE VEVSIEGK--MG--KPHGIRTARKHRTNRRVQVWADKDYKKAHLGTRWKANPFSGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPKDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALFKGKKERPRAXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXMADLPICLVADS----TVVINVTGT-TSVGQLKDLVREKLSLSGDADDFYLRTGA NILSEDSQTMAEYGIVTPFSHVYFSQRLLGGKVHGSLARAGKVRGQTPKVEVQEKKK-KK TGRAKRRMQYNRRYVNVVA-TFGRKRGPNSNADAGANKNMA >Ascaris XXXXKFSAPRHGSMGFTPKKRSRRHRGKVKAFPKDDPTKPIHLTAFIGFKAGMTHIVREV DKPGSKVNKKEVVEAVTILETPPMVIVGIVGYIDTPRGPRQFKTVWAEHLSEDCRRRFYK NWHTSKKKAFQKHAKKWQDEDGRKSIESDLNKMKKYCSKIRVIAHTQMKVMKHREKKAHI MEIQVNGGTVPEKVDWAKEHLEKQVAVDSVFAQDEMIDCIGVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEVNKKIYRLGKSCLTEEGK--- RNGGTEYDITEKSINPMGGFPHYGLVNQDFVMIRGCCVGSKKRPITLRKSLIVQTKRFAH EKINLKWIDTSSKLGHGRFQTHAEKRAFMGKLKKDLIAESEAAKA--------------- ------------------------------------------------------------ --MRFSAARMYAKRGV---YA--KKPFPVEKKTPIVKEKFIIKQIGGD-KNGG--TRKVF LDKG--P-KYLPEARTTRR-KIKRPAKKVPLRSSITPGTVLIILAGRHKGKRVVFLKQLE KSGLLLVTGPLKLNSTPLRRIAQAFVIATKTKIDVSGVKIPEHIDDAYFRRINSKKAPKK G---DA-SIFA-QSTAEYTVSEQRKADQKEVDTPILAAIKKHPEHKFLFGYMGSRFALGK NQYPHEMVFMGLRIRVQRKGPGGIFKAHNKHRKGAAKLRPVDYAERHGYIKGVVKDIIHD PGRGAPLAIVQFRDPYKYKTNKCTMIAAEGMHTGQFIYCGRKAQVQVGNVLPLAELPEGT TVCNLEEKTGDRGRLARTSGNYATVIAHNPETKKTRIRLPSGAKKVVQSSNRAMVGIVAG GGRTDKPLLKAGRAYHKYKAKRNCWPTVRGVAMNPVEHPHGGGNHQHIGHPSTVKRGTSA GRKVGLIAARRTGRIRGGKPEKHG-KEEAVMGRRPARCYRYIKNKPYPKSRFCRGVPDPK IRIFDLGKKKADVDEFPTCVHLMSNEREHLSSEALEAARICANKFMVKNCGKDGFHMRVR KHPYHVVRINKMLSCAGADRLQTGMRGAYGKPQGLVARVDIGDLLISVRVKEQHADYAVE AFRRAKFKFPGRQLIVVSRKWGFTKWNKEDFESMRTQGRLTMDGANCKLVREHGPLSKWI HNPI----------------------------------------------MGKAEQLAEI REKKAANPMRELKIQKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEIIERGLKVKEYELYRENFSNSGNFGFGIQEHIDLGIKYDPSI GIYGMDFYVVLDRAGRRVAKRRRARGRVGHSHRVEKEEAVKWFQQKYDGIILPPKAKEVR --HGRRR-MPPKFDPTEIKIVYLRCVGGEVGATSALAPKVGPLGLSPKKIGDDIAKATAD WKGLKVTCKLTIQNRVAKIDVVPSAASLIIKELKEPPRDRKKVKNVKHSADLSIDQIINI ARQMRPRSMAKKLEGTVKEILGTAQSVGCTVNGQHPHDVVDAIRSGDIVIPEDMGKIHYS CQPENSTKSCKARGSDLRVHFKNTHETAQTIKHMPLKRAIRFLENVKEKKEIVPFRKFNH CVGRKAQAKAWGHTQGRWPVKSAEFLLQLLRNAESNAEYKGLDTDHLVVEHIQVQRAAKM RRRTYRAHGRINPYMSSPCHIEVILSEKEEVVSKPT--DEVG-KVKKES-KKK-QRRIL- ARGEY-MGKIMKSGKVVLVLGGRFAGRKAIIVKAYDDGSADRAYGHALIAGIDKYPKPVT KAMGKKKVAARSKLRPFVAVAGYSNLLPTRYSV-DITLDKNSVNKDVLKEPGKKRKARLE VKSKFEERYKTGKNKWFFTKLRFMVPPKKGAKRDRKGRSAMSEVVTREYTINLHKRIFGV GFKKRAPRAVDEVRKFAEQQMGTKDVRVDTRLNKFLWSKGIRNVPYRVRVRLSRRRNDDE DSPYKLYTLVTHVPVTSFKKLTTVNVDSEE-MPQRLTYRRRLCYNTRSNKTRVSKTPGGR LVFLYRKKLGSVPR--CGDTGVKLKGIKPARPRQLSKMTKRLKKVSRTYGGCLSAAAVRE RIIRAFLIEEQKIVARVLKAKKNAEKK--------------------------------- ----------------MPKQITEITEFLLTARRKDAKSVKIKKNSENV-KFKVRCSKYLY TLVIQ-DKEKAEKLKQSLPPGLQVKELKMAAHKTFIIKRKLAKKAKQNRPLPQWARMKTG NKIRYNAKRRHWRRTKLKLMAHQA-A--TNSEVACVYAALILQDDDVAITGDKITTILKA AHVE-VEPFWPGLFAKALEGVDVKALITNVS-SGVGSGGPAPAGGAA--P-AAAAAPAAE AAP-KEEKKEE--P-KEE-----SDDDMGFGLFDMAVGKNK---KMGKKGAKKKVVDPFT RKEWYDIKAPSMFTNRQVGKTLVNRTQGTKIASEGLKGRVFEVSLG-DLNNS---EFDFR KFRLICEDVQGRNCLTNFHGMKFTRDKLCSIVKKWHTLIEANVAVKTSDGYLLRLFCIGF TKKNVGQLKKTSYAKSSKIRQIR-AKMIEHMQKEVQGSDLREVCNKLIPDSIGKDIEKAC AYIYPLQDVYIRKVKILKKPKFEVGRLMEMHGDISSYTNAEGE----------KVDRP-- DDYEPPVQESVMA-RGPKRHL-KRLAAPHHWMLDKLGGVFAPRPTSGPHKLRESLPLILF LRNRLKYALSYNEARMICKQRLIKIDGKVRTEMRFPAGFMDVITIEKTNETFRLLYDAKG RYTVHRITEAEGRFKLCKVVKKSVGPKGVPFIVTHDARTIRYPDPHVKVNDTIVLDIASG KFNDYVKFDQGNLCMVTGGRNMGRVGVVGHREKHPGSFDIVHVKDAAGHTFATRLNNVFI IGKGTKSLVSLPGATKGVRLTIAEERDKRLAQKKAA--------------------MGDC WVTESNDVAGLDEPMGQSDLPEVKLFGKWSLDEVYVSDISLVDYVAVKNKSAKYLPHSAG RYQVKRFRKATCPIVERLASSMMMHGRNNGKKLMTVRIVKHAFEIIHLLSGENPVQVLVN AVINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MPETVP-KIVKPGGKMPNE FEKQVSNAIADLETSPDIKAQLRELYIVGAKEVELGN-KKVIIVYVPFPQLRQFQ-KIQP RLVRELEKKFSGRHVVVIARRRIIAKPKRGKSRKPEKQKRPRSRTLTAVHDAMLADLVFP AEVVGRRIRVKLDGKRIMKVHLDKNQQTNVEHKVDTFSAVYKHLTGKDVAFEFP-EPLF- ---MPRIKNVMSKVYKSPRRPFEKERLDQELKLIGEFGLRNKREVWRVKYTLAKIRKAAR TLLTLEEKDPRRLFEGNALLRRLVRIGVLSEDRMKLDYVLGLRVEDFLERRLQTQVFKLG LAKSIHHARVLIRQKHIRVRRQIVNVPSFIVRLDSQKHIDFSLKSPFGGGRPGRVKRRNA KKGSGGDG-E-GSEADEMLMPTKNRRAIYEYLFKEGVCVAKKDYNQKTHPDIQN--VTNL EVIKACKSLASREFVKERFAWRHHYWYLTNEGINYLREYLHLPAEIVPATVKSKPRE--- -PRPAFAGDRLTRAPKMD----SDRDAYRAS---------EKATEAGPGAAPVSGYRG-G Y-GRGAGAM-------------------M--DATGDEVRLQGAVV------DEKLDVQAA FNRALKSAIVVDGLSKGLHEAAKALDKRQAYFCVLAENCDEPMYTKLVEALCTEHQISLI KVKDKKQLGEWIGLCKYDKEGKARKVVGCSCAVVRDFGQDDAARLVLQEYFEXXXXXXXX XXXXXXXXXXLLHEAALAELKKKRTFRKFSYRGVDLDQLLDMNRDQLAKLLPCRARRRLA RGLKRKHLTLLARLRRAKKEASVLEKPATVKTHLRDMLVLPEMVGSMIGVYNGKVFNQVE VKPEMIGHYLGEFSISYKPVKHGRPGIGATHSSRFIPLKMTAST---------IQSVQVF GRKKTATAVAYCKKGRGLIKVNGRPLEHMQPEILRIKLQEPLLILGKERYQEVDIRVRVT GGGHVAQIYAIRQALAKAIVAYYQKFVDEQSKKELKEQLTSYDRNLLVADPRRREPKKFG GSGARARYQKSYR---MVCGRVRTKTVKKASRVIIEKYYTKLTHDFHTNKRICEEIAVIP SKKMRNRIAGFITHLMKRIEKGPVRGISIKLQEEERERRDNYMPEISVVDPRELPSIDVD T-ETKQMIDAMDMTIPNLNEIKASNVVLPVRR---------------------------M AGVPY-KTEKPVT----VDET----EHRIRITLTSQNVSSLEKVCEQLIQGAKDKSLVVK GPIRMPTKVLRITTRKTPCGEGSKTWDRYQMRIHKRLINMHSPSDVLKQITSISIEPGVD VEVTINDS--XXXXXXXGIRTVRKLKTHRQAQRWNDKGYKKAHLGTRWKANPFGAASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKIVKVANTSLSALFKGKKERPRSGKKRKKKTYTTPKKNKHKRKKVKLA VLKYYKVDENGKISRLRKECSSPTCGGGVFMASHQNRYYCGKCYQTLVMQDPKEKAAGSK K----XXXFALLNDSCHDAGSFNAIDGQVHLVEVTPETTIAQLKSQLE--AFDSVLTFGT RILDEDDCSLSQLDIVH-GSTLNINARLIGGKVHGSLARAGKVRAQTPKVDKQEKKK-KK TGRAARRIQYNRRFVNVALNGPGRKRGPNSNAA-------- >Meloidogyne MSHRKFSAPRHGSMGFTPKKRSKRHVGKCKAFPKDDPSKPIHLTAFIGYKAGMTHIVRDV DKIGSKVHKKEVVEAVTIIETPPMVIVGVVGYIETPRGPRPLKAVFAEHLSEDCKRRFYK NWYKCKKKAFTKYAKKWQDEDGQKSIEADLNKIKKYCAYVRVIAHTQMKLMKHRNKKAHI MEIQINGGTVSEKVDWAREHFEKQIPVDQVFEQDEMIGCIGVTKGKGFKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEINKKIYRIGKSCLTPEGK--- KNGSTDFDTTEKTINPMGGFPHYGLVNQDFVMIRGCCVGPKKRPITLRKSLITQTKRFAF EKIDLKWIDTSSKFGHGRFQTSAEKKAFMGKLKKDFLAETTVS----------------- ------------------------------------------------------------ --MRFSKARMFHKRGL---WEKLKKPYQKQKKKVEAKEKFIVKKIGGD-KNGG--ERKIF VQKP--P-KLLPQVPQLLK-RNKRKTKKVPLRKSITPGTVLIILVGRHRGKRVVFLKQLE KSGLLLVTGPLKLNACPLRRISQSFVIATSTKIDIGKVEVPVHVDDAYFKRKSGKV-ADK S---KG-GIFADGAKQKYEVTEQRKTDQKAVDAGVLDAIRAHPEKKYLYGYLGSRFHLAK GMYPHKMNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYIKNKPYPKSRFCRGVPDPK IRIFDLGRKRATVDEFPCCVHMISNEREHLSSEALEAARICANKYMVKNCGKDGFHMRVR IHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGLVARVGIGTVLMSVRVRDQHQAHALE AFRRAKFKFPGRQYIVVSRKWGFTQFDREVYENYRKEGRVVPDGVHCKLIREHGPLTRWI KNPI----------------------------------------------MTKAEQIVEN REKKLHNTMRELKIQKLCLNICVGESGDRLTRAAKVLEQLTGQTPVLSKARYTVRAFGIR RNEKIAVHCTVRGSKAEEIIDRGLKVKEFELYRENFSDTGNFGFGIHEHIDLGIKYDPSI GIYGMDFYVVLGRAGTRVAKRRRAIGRIGSSHRVTKEESVKWFQQKYDGVILPPKPKEVR KEGGRRKRMAPKFDPTEIKIIYLRCVGGEIGATSALAPKVGPLGLSPKKIGEDIAKATQD WKGLKVTCKLTIQNRIAKIDVVPSAASRIVKELKEPHRDRKKVKHVKHSGNLTIEQIINI ARQMRPRSMAKKLEGTVKEILGTAQSVGCTVDGQHPHDIVDAIRSGKIEIPEEMTKVHYC KHPNNNKKSCKARGSDLPVHIKNTHETARAVKGMPLKRAIRFLENVKEKKEIVPFRHFNG GVGRKAQAKAWGTTQGRWPKKSAEFLLQLLRNAESNAEVKGLDVDHLVIDHIVVQAAAKM RRRTYRAHGRINPYMSSPCHIEVILTEKKEIVSKPA--GAIV-KVKKES-KKK-QRRQL- ARGEY-MGKIMKSGKVVLVLRGRFAGRKAVVVKTYDEGSTERTYAHALVAGIDKYPRKIT RAMGKKKQEKRNKLRPFVKVISYSHLLPTRYTV-DVAFDKNHINKESLKEPSKKRRASQE VKAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMPQRLTYRRRLCYNTKSNKTKVVKTPGGR NVLHYRKKKGSIPK--CGDTGVPLKGIKAARPRQLSKMTKRLKTVTRAYGGCLSAAAVRQ RIIRAFLVEEQQIASKLLKTKGVVKK---------------------------------- ----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXMAAHKTFIIKRKLAKAAKQNRPLPQWVRMKTG SRIRYNAKRRHWRRTKLKL----M-A--SNQELACIYAALALQDDGVPITGEKILTILKA AGVE-VEAFWAGLYAKALEGVDVKALISNIG-SGIGSGGGAAASAGTAAP-AAAEKAAAP AA-EEKKKKEE--P-KEE-----SDDDMGFGLFDXXXXXXXXXXXXXXXXXXXXXXDPFT RKDWYDIKAPAMFATRYIGKTLVNKTVGTKISSDFLKGRVYEVSLG-DLNNT---EADFR KFRLICEEVQGKVCLTNFHGMTFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXMA-RGPKKHL-KRLAAPKNWMLDKLGGVFAPRPMCGPHKLRESLPLILF LRNRLKYAQSYNEARMICKQRLIKVDGKVRTEMRFPAGFMDVVSIEKTGEVFRLLYDVKG RFITHRIQKEEGQLKLCKVVKQAIGPKQVPYIVTHDARTIRYPDPHIKVDDTVAVDINTG KVTDHIKFDSGNVCMITGGHNMGRVGIVGHRERHPGSFDIVHIKDSAGHAFATXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------MADDFAPSGDGLPADDN WGATDVPGGQGDMQMTTIDFPEIKLFGKWSLSDIEVNDPSLVDYIAVKDKSAKYLPHSAG RYQIKRFRKAHCPIVERLVCSMMMHGRNNGKKLMAVRIVKHAFEIIHILTGENPVQILVG AVINGGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGSREASFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MATFE--KLVKTDGKAPDD LEKQVATAITELSQTNGEIKNQLSELYFVGAQQFEFG-NKKCILIWIPVPQLRDYQKIHP KLVRELEKKMSGYHIIFIAKRQILQKPQRGKNRKPLGQKRPRSRTLTAVHEAILQDVVFP AEVVGKRTRVKLDGKQIIKVHLDKAQQTTVEHKVDTFSYLYKRLTGKEVVFEFP-EPXXX X--MPRIKHVFSKVYDVPRRPFEKERLDQELKLIGEFGLRNKREVWRVKLTLAKIRKAAR ELLTLEDKDPRRLFEGNALLRRLVRIGVLLEDKMKLDYVLGLRVEDFLERRLQTQVFKLG LAKSIHHARVLIRQKHIRIRRQVVNIPSFIVRLDSQKHIDFSTKSYLAGGPPGRVKRKNL KKAASGGGGGGGDDEEDMLIPQADRKKIYEHLFEDGVCIAKKDYVSKSHPEIKG--VRNL YVIKALKSLTSKGLVREQYAWRHYYFYLKEDGVPYLREYLDLPEDALPNTHKQRTEPSRM PYPDKMGGGGAGRGFPSG---EDDRGAYRTMG--------DKQADAGPGSMPV---RQ-G F-GRGGPPTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXRGINEAARTLDKREAFFCIYAKGCDEPSYEKLVRSLCNQHGIPII EVENKSKLGQMVGQCKVDKEGKARKIVGCSVAVVKNYRRDDEAKSEMEEILKKVKVGGND E------MTDVAEQ------KKKRTFRKFVYRGVDLEQLLEMNDQQFNKLLPSRQRRKMN RGLNRKHKSLLVRLRKAKLNAPELTKPECVKTHLRDMIVLPEMVGCVLGIHSGKAYNQVE IRAEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKXXXXXXXXXXXXXXXQPVQVF GRKKTATAVAYAKKGKGLIKVNGRPLEFLQPEILRIKLQEPLLIVGKDKFAGMDIRIRVK GGGHVAQIYAIRQSIAKVLVAYYQKNVDEQSKKELKDQLVAYDRNLLVADPRRHEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASRVIIEKYYTRLTYDFHVNKRICEEIAVIP SKRMRNQIAGFITHLMKRIEKGPVRGISIKLQEEERERRDNWVPEVSYLDASQHPTISVD Q-ETKEMVDYLQLNLPVDVKGQQQQGQAQGGGGQQQQQQPAAAARQ-------------M AYAY--KDDKKAE----EPQP----VERIRIILTSQNVKALEKVCEKLIHGAREEHLAVK GPIRMPTKVLRITTRKTPCGEGSKTWDHFQMRIHKRIINLHSPSDVLKKITGIPIEPGVD VEVTIADSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGKKRKKKQYTGPKKQKHVRKKVKLA VLKLYKIDDNGQIQRQRIECNSATCGAGIFMAKHKDRHYCGKCHQTLTEKKG-------- -----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX >Haemonchus MSHRKFSAPRHGSMAFTPKKRSRTYRGRIKAFPKDDPSKPIHLTAFLGYKAGMTHIVRDV DKPGSKVNKKEVVEAVTIIETPPMVIVGIVGYIDTPRGPRAFKSVFAEHLSEDCRRRFYK NWCKSKKKAFTKYTKKWMDEDGKKAIESDLNKMKKYCSSIRVVAHTQMKILNRKQKKAHL VEIQINGGTIAEKVDWAKDHLEKQVPIDTVFSQDEMIDTIGVTKGHGFKGVTSRWGTKKL ARKTHKGLRKVACIGAWHPSRVAFTVARAGQKGYHHRTHINNKIYRIGRSCLTPEGK--- NNGATEFDLTEKSINPMGGFPRYGLVNQDYVMLRGAVLGPKKRLITLRKSLVVQTKRFAH EKINMKWIDTSSKTGHGRFQTTAEKKAFMGKLKKDFLAESKA------------------ ------------------------------------------------------------ ------------------MVGGRNVPVLGRNFDLSPAVSRFSAARMYL-RRGAKKPLVKK SAE---P-LTLPLQRTGPK-FKLGHPKKVPLRKSLVPGTVLIVLAGRHKGKRVVFLKQLP KSGLLLVTGPHKLNNFPLRRIAQAFVIATKTKLDVSGVKIPDHINDDYFKRKTL--PGKK G---E--NIFA-AGKVEYQVTEQRKTDQKAIDKPILAAIKKNPDHKFLFGYLGSRFMLGK RQYPHNMVFXXRRIKVQRKGAGGIFKSHNKHRKGAAQLRPLDYAERHGYIRGVIKDIIHD PGRGAPLAIVAFRDPYKYKTVKSTVVAAEGMYTGQFVYCGSKASVQVGNIVPVGSLPEGT TICNVEGKCGDRGKLAKCSGTYATVIAHNPETKKTRIRLPSGAKKVIQSANRAMIGLVAG GGRTDKPMLKAGRAYHKYKAKKNSWPQIQSLLXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYIKNKPYPKSRFCRGVPDPK IRIFDLGKKKASVDEFPCCVHMMSNEREHLSSEALEAARICANKYMVKNCGKDSFHLRVR KHPYHVTRINKMLSCAGADRLQTGMRGAYGKPQGLVARVDIGDILFSMRVKESNVNHAIE AFRRAKFKFPGRQLIVVSRKWGFTRWDKADYERMRAEGRLRSDGVGVQLVREHGPLEKWV NNPI----------------------------------------------MGDAEKAAEI REKKAKNMMRELKIQKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVKEFELYKENFSDSGNFGFGIQEHIDLGIKYDPGI GIYGMDFYVVLDRAGRRVARRRRAPGRVGPSHRVYREESVKWFQQKYDGIILPPKPKVKR TVH-RRR-CRQSFDXXEIKIVYLRCVGGEVGATXALAPKVGPLGLSPKKVGDDIAKATQD WXXLXVTCKLTIQNRVAKIDVVPSAASXLVKELKEPPRDRKKVKNVXHNGDLXLDSIIKI ARIMRPRSMARKLEGTVKEILGTAQSVGCTIDGQHXHDIIEQIASXEIEIXAEMTKIHYT KNPDNSTKSCKARGSDLRVHFKNTHETAMALRNMPLRRAQRFLENVKEQKEIVPFLRFNG GVGRKAQCKQWNTTQGRWPKKSAEFLLDLLKNAESNAEYKGLDVDHLVVDHIVVQRAAKM RRRTYRAHGRINPYMSSPCHIEVILTEKEDVVAKPT--DDI-PRTKKES-KRK-QRRQL- ARGDY-XXXXXXXXXVVLVLRGKYAGRKALVVKAQDEGGADRSYPHAIIAGIDKYPLKVT KSMGKKKQEKRNKLKPFVKVVSYSHLLPTRYSV-DVAFDKANINKESLRIPKKKRCALAE IKSKFEERYKTGKNKWFFTKLRFMV----KAKQDRKARNAINEVVTREYTIHMHKRIKGV GSKKRAPRAIDEIRKFAKQQMNTEDVRIDTRLNKYVWSKGIKNVPFRIRVRLSRRRNEDE DSVHKLYTLCTFVPCTNFKNLTNVNVDSEE-MAQRVTYRRRLSYNTRSNKCKIVKTPGGR LIYQYLKKRGSVPR--CKDTGVKLHGITPARPRELTRLKKNQRTVSRTYGGCLSPNAVKE RIIRSFLLEEQKIVSKVLKSRRGADN---------------------------------- ----------------MPKQITEIKDFLVLARRKDAKIVKIKKNSLNV-KFKVRCSRYLF TLVVN-DKDKAEKLKQSLPPGIQVIELKMAALKKFFIKHKLAKKQKQNRPMPQWARMKTG NTMKYNAKRRHWRRTKLKL----M-A--LNQEMACVYAALILQDDEVAITGDKIATLLKA ANVD-FEPFWPGLFAKAVEGVDVKNLITSVS-SGVGSGGGAAAPAGG-APAAAAPAAAAP AA--ETKKKEE--P-KEE-----SDDDMGFGLFDMAVGKNNN--KMGKKGGKKKAVDPFA RKEWYDIKAPSMFYNRQVGKTLINKTQGTKIASEGLKGRVFEVSLA-DLNDS---EADFR KFKLVCEDVQGKNVLTNFHAMSMTRDKLCSIVKKWHTLIEANGVFKTTDGYVLHLFCIGF TKRSPNQVKKTTYTKASKVRKIR-ARMLELMKKEVSGCDLKEVCSKLIPDSIGKDIEKAC HGLYPLQDVYIRKVKILKKPRLDLGRLMEMHGD--------------------------- -----------MA-RGPKKHL-KRLAAPKHWMLDKLGGVFAVRPRSGPHKLRECLPLNLF LRNRLKYALNYSEVKKIMRQRVVKVDGKIRTDHKFPAGFMDVISIERTNETFRLLYDVKG RYTVHRITAAEGQFKLCKVKALHVAKKNIPYITTNDGRTIRYPDPHIKVNDTVVIDLTSN KITDYVKFEAGNLAMVTGGRNVGRVGVIGHREKLPGAFDIIHIKDAAGHSFATRVTNVFV IGKGNKALVSLPAS-KGIRLTIAEERDKRLAXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXLFEQQGVQPPAPLELPEPKLFNKWSLQDVDVSDISLVDYIGVKEKHSKYLPHTAG RYQTVRFRKAGCPVVERLCNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLSGENPVQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLICTGAREAAFRNVKTIAECLA DEIMNAAKGSSNSYAIKKKDELERVAKSNR-----------MPEIIG-KLMKPDGSVTTE LEKQVSQALVDLESSADIKAQLRELYIVGVREIEIGN-KSVIVVYVPVPQLKQFH-KVQV RLVRELEKKFGGKHVLFLAKRRILPKPLRGSKKVPMKQKRPRSRTLTAVHEAWLDEMVFP AEVVGKRTRVKLDGKKLLKVHLDKAQQTNVEHKVDTFVSVYRKLTGKEVAFEFP-DPIF- -XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXMLIPSKNRKAIFEYLFNEGVAVAKKDYNLKQHPNIPG--VTNL EVIKALKSLASRELVKEQFAWRHYYWYLTDEGIAHLREVLNLPAEIVPSTVKSKPRDIRA -PTDIRERIP--RPVPGK---EGDRDAYRVA---------EKVTEAGPGSAMP--YRA-G F-GRGAP----------PPQ--------M-ADAGGDEVKIPSAAP-------AVMDVQAA LKAVLRSANFADGLAKGLHEAAKALDKREAHFCVLAENCDEPMYVKLVEALCNEHNIPLI KVADKKIIGEWCGLCKYDKEGKARKVVGCSCAVVKDYGNEEIGKQVLQQYFDSKK----- -------MADQDEAHLAEL-KKKRTFRKFTYRGVDLEQLLDMSRDQFAKMLPCRMRRRXA RGLKRKHLNLISRLQKAKKAANVLEKPATVKTHLRDMVILPEMVGSVIGIYNGKVFNQTE IKPEMIGYYLGEFAITYKPVKHGRPGIGATHSSRFIPLKMTRQE--------PIQAVQTF GRKKTATAIAHCKKGRGLVKVNGRPLEHLEPQILRMKLQEPLLVVGKERFQDVDIRIRVS GGGHVAQIYAVRQALAKALVAYYHKYVDEQSKKELKDQFFAYDKSLLVADPRRTEAKKFG GPGARARYQKSYR-----MSRVRTKTVKKASRVIIEKYYTKITHDFHTNKRICDEVAIIG SKQLRNKIAGYITHLMKRIEKGPVRGISIKLQEEERERRDNYMPEISAVDASVIGQLKVD P-DTKHMLESMDFNLPNVVVDEQKSLKKY------------------------------M AGVAY-KNEKPL-----ADNT----EHRIRLTLTSQDVKSLEKVCAQLIEGAKKENLVVK GPIRLPTKVLRITTRKTPCGEGSKTWDRFQMRIHKRLINLHTPADLLRQITSISIEPGVN VEVTQAN---MG--KPKGIRTARKLKIHRQSQRWCDKAYKKAHLGTRWKSNPFGGASHAK GIVLEKIGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFVEENDEVLVSGFGRS GHAVGDIPGVRFKIVKVANTSLSALFKGKKERPRSAKKRKKKVYTTPKKIKHKRKKVKLA VLKYYEVDDNGKIRRLRKECQSPSCGGGVFMAAHENRYYCGRCHDTLVVEEPVVTSKAKG GKGKKMQIF------------INALDGGIHRLEVAPETTVAQIKKNLG--ADEHILSYGS SV-LEDSLSLSSLDITD-GASLAINARLLGGKVHGSLARAGKVRAQTPKVEKQEKKK-KK KGRAARRIQYTRRFVNVAT-GPGKKRGPNSNSA-------- >Lumbricus MSHRKFSAPRHGSLGFLPKKRSRRHRGKVKAFPKDDKSKPVHPTAFIGYKAGMTHVVREV DRPGSKVHKKEVVEAVTILETPPMIVVGLVGYIDTPKGLRTFKTVWAEHLSDECKRRFYK NWYCSKKKAFTKASLKWQDESGKKEIEKDLSKIKRYCSVVRILAHTQMKLMNRRQKKAHI MEIQLNGGSVPDKVEWGQTHLEKPIPVQQVFDQDEMIDVIGVTKGKGFKGVTSRWHTRKL QRKTHKGLRKVACIGAWHPSRVSFSVARAGQKGYHHRTEINKKIYRIGQGVHTKDGRVVK NNASTEYDLTEKTITPMGGFPHYGVVNQDFIMLRGCCMGPKKRVITLRKSLLLQTKRKAT EKVNLKFIDTSSKMGHGRFQTREEKQTFMGPLKKDKTKETPAA-------------XXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXKKKAKAKPKTEKPKPAPRFIEKQVDGE-KNGKTRRVPVK RASKYYPTQEKSWRLRTH--KKPFSQHKRHLRESITPGTVLILLAGKHKGKRVVFLKQLA -TGLLLVTGPYHLNGCPLRRINAIYAIATKTKLDVSSVKLPERVNDAYFKRKEI-KRPKH T---EG-EIFT-TKKEEYTPSAERKEDQDVVDKQLLDVIRQHPEKKYLFGYLGAMFSLKN GDRPHKMIFMGRVIRSQRKGAGGIFKAHTKNRKGAAKLRAVDFAERHGFIKGVVKDIVHD PGRGAPLAKVVFRDPYRYKLRTETFIAAEGMHTGQFLYCGKKANLQVGNVLPIGSMPEGT VICCVEEKTGDRGRLARTSGNYATVIAHNVETKKTKIKLPSGTKTTIPSNNRAMVGIVAG GGRIDKPMLKAGRAYHKYKAKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVARDKSA GRKVGLIAARRTGRLRGTKQVTGKATEKE-MGRRPARCYRYCKNKPYPKSRFCRGVPDAK IRIFDLGRKRAKVDEFPLCIHLVSDEFEQISSEALEAGRICANKYLVKHCGKDAFHLRVR LHPFHIIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVDIGQVIMSVRAKDGHKEKVIE ALRRAKFKYPGRQKIHVSRKWGFTKWDRENFEALRAENRLVPDGVSVQYKPDHGPLAAWY AANK---------------------------------------------MASDGESP-AK DDKKKNNPMRDLRILKLCLNICVGESGDRLTRAAKVLEQLTGQTPVYSKARFTVRSFGIR RNEKIAVHCTVRGAKAEEILDKGLKVREYELKRGNFSCTGNFGFGIQEHIDLGIKYDPNI GIYGMDYYVVLGRPGYSISKRRRAHGSIGHKHRVTKEEAIKWFQQKYDGVILPGK----- --------MGPKFDPSEIKVVCLRAVGGEVGATSALAPKIGPLGLSPKKVGEDIAKASQD WKGLRITVQLTIQNRQATIAVIPSASSLIIKALKEPPRDRKKVKNIKHTGNLSLDEVIAI ARTMRVRSMAKALSGTVKEVLGTCQSVGCTVEGSHPHDIIDKINAGEQEVPEAMTR--YS LPPENPAKSALARGSHLRVHFKNTRETAQVIKHMHLRRAVAFLKNVIAHKECVPYRRFTG GVGRCAQAKQWGATQGRWPKKSAEFLLQMLKNAESNAEFKGLDTDHLVIDHIQVNRAPKM RRRTYRAHGRITPYMSSPCHIEIILSEKEQAIAKPQ--EE-GGEKKKVS-QKK-LKKQK- MMMRE-MGKFMKNGKVVLVLGGRYAGRKAIIVKNYDDGSTDKPYGHALVAGISRYPRGVT KKMGKKKIKQRSKVKAFIKVYNYNHLLPTRYSV-DVEVDKRVVNKDIFKDGALRKKANQE MKAKFEERYKSGKNRWFFQKLRFMT----AAKKEMKKKSVTNEXVTREHTINLHKRIHGV GFKKRAPRAIGEIRRFAEKAMGTPDVRIEARLNKHIWSQGIRNVPFRVRVRLARKRNEDE DSPNKLYTLVSYVPVTSFKGSQTVNVESE--MVQRLTLRRRLSYNTNSNRRKITKTPGGK LVYHYKKKLGSVPK--CGDCKRKLQGITPSRPLERCRMSKRLKSVTRTYGGSRCHKCVRE RIVRAFLIEEQKIVMKVLKAQGGGGKKAQ------------------------------- ----------------MPKQVLEIKDFLMTARRPDAKSVKIKKNKEGSTKFKLRCSRYLY TLCIN-DGEKADKLRQSLPPGLQVKDLKMAAHKTFRIKMKLAKKMKQNRPVPQWVRMKTG NTIRYNSKRRHWKRTKLKL----M-A--TEDQLACTYGALILADDEIPITAEKLNTILKA ANVQ-VEPIWPSLFARALSGINVRDLITKVG-SAAGPAAPAAAAAAA--PAGDAKK---- -EEKKEEKKEE----KKEEEEE-EDEDMGFGLFDMAVGKNKRLSKGGKKGGKKKVVDPFS KKDWYDVKAPSMFNNRNIGKTIVTRTIGTKIASDGLKGRVFEVALA-DLQND---EIAFR KFKLMSEEVQGRNVLTNFHGMDMTTDKLKSMVKKFQTLIEAHVDVKTTDGYLLRLFAIGF TARRQNQDKKTSYAQSTQVRAIR-KKMVDIMTREVSSSDLKDVVNKLIPDSIGKDIEKVS QGIYPLHDVYIRKVKVLKKPKFDLGKLLELHGEGGTTTTKTV--GEGG----EKIERA-- DNYEPPVLESVMV-RGPKKHL-KRVNAPKHWMLDKLGGVFAPRPSCGPHKLRECLPLSIF LRNRLKYALTYDEAKRILNQRLIKVDGKIRSDKTYPAGFMDVVSIEKTNENFRIIYDVKG RFAIHRITAEEAKYKLCKVKKVQVGLKGVPSIVTGDGRTIRYPDPLIKVNDTVKISIDTG KIDEFIKFDSGNICMVTGGHNLGRVGLVTHRERHPGSFDIVHIKDSLGHTFATRLNNVFI IGKGNKPWISLPRG-KGVRLTIAEERDRRIQSKQ-------------------------- -------MAEVFEELPVVEAQDVKLFGKWSSDDVNVNDISLTDYIAIKDKYAKYLPHSAG RYQAKRFRKAQCPIVERLTDSLMMHGRNNGKKLMSMRIVKHSFEIIHLLTGENPLQILVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREASFRNIKSIAECLA DELINASKGSSNSYAIKKKDELERVAKSNR-----------MYSTSA-KIQKPEGEKVDE LESSISQALLELEMNSDLKAQLRELVFTGAKEVDVQN-RKAIIVYVPVPQLRAFQ-KIQP RLVREMEKKFSGKHVVIIAQRRILPKPTRKSKTK-NKQKRPRSRTLTHVHDAILEDLCFP SEIVGKRIRVKLDGTRLIKVHLDKSQQTNVEHKLDTFAAVYKKLTGKDVTFEFP-EYVL- ---MPRIALVRSKTYSTPRRPFEKERLDQESKLIGEFGLRNKREVWRVKYTLTKIRTAAR ELLTLDEKDPRRLFEGNALLRRLVRIGVLDEQKMKLDYVLGLRLEDFLERRLQTQVLKLG LAKSIHHARVLIRQRHIXVRKXXVNLPSFIVRLDSQKHIDFSLKSPYGGGRAGRVKRKNQ RKATGGG----DAEEEDMLMSKKNRVMIYEYLFKEGVLVAKKDFHLPKHGEID---VPNL HVIRAMQSLVSRGYVKEQFCWRHYYWYLQNEGIQYLRDFLHLPPEIVPATLKRQTRPEAA RPRPK--EGAP-RAQV-----GEDRAGYRRGFGGS-----DKKGEAGAGADTQFQFRG-G F-GRGRQEQEE-----------------M-SDVEGDDVAAAAA-PTPVAVSTGPMDLNVA IQEVLKTALIHDGLARGLHECTKALDKRQAHLCVLANNCDEQNYVRLIEALCAEHGINLI KVESNKKLGEWVGLCKLDKEGKARKVVGCSCVVVKDYGKESQALDVLNEYFKTRK----- -------MADTAETQDILEKKKKRTFRKYTYRGVDLDRLLDMSNDSLMLLFPCRVRRRFA RGLKRKHMALLKRLRKAKKEAPALEKPECIKTHLRNMIIIPEMIGSIIGIYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMAAKPA--------LQYVEVF GRKKTATAVAHCKRGVGLIKVNGRPLELLEPEMLRAKVQEPILLLGKERFAGVDMRVRVK GGGSNAQIYAVRQAISKALVAYYQKYVDEASKKEIRDILISYDRSLLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKASRVIIEKYYPRLTLDFHVNKRICEEIAIIP SKKLRNKIAGFVTHLMGRIQKGPVRGISIKLQEEERERRDNFVPEKSAIE-EDIIEIDAD TKEMLKAIDMEKIQNLQVIAPVANQTFKGPRGGNVPGAAA-------------------M SQY----KDSGKA--PAEEAT----VHRIRITLTSRNVKSLEKVCADLIRGAKDKQLKVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KPRGLRTARKLKNHRREQRWHDKDYKKSHLGTRWKSNPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPRDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVASVSLLALYKQKKERPRSAKKRKKKNYTTPKKNKHRKKKVKLP VLKYYKVDDNGKITRLRRECPNDECGAGVFMASHXDRQYCGKCGLTYVFNKPEEKV---- -----MQLFVQGSE-------LHALQLSSDGVTIGDLKAQLAILENAS-VEDLALYCAGK --PLEN--EFIVARCVSDSATLDLDLRMLGGKVHGSLARAGKVKGQTPKVEKKEKRK-KK TGRAKRRMQYNRRFVNVVA-GFGRKKGPNSNXQQ------- >Argopecten MSHRKFSAPRHGSKGFLPKKRASRHRGKVKAFPKDDKNKPVHLTAFIGYKAGMSHIVRDV DRPGSKSNKKEIVEAVTIIETPPMVIVGLVGYIETPSGLRTFKTIFAEHLNEDCRRRFYK NWYNCKKKAFTKYAKKWTDENGKKEIERDFQKMKKYCKVIRVIAHTQTKLLKKRQKKAHI MEIQVNGGTISQKVDWAREKMESSVPVGSVFAMDENIDIIGVTKGKGVKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEINKKIYRMGEGTHTKDGKLVK NNASTDFDPSEKNITPMGGFPHYGEVNNDFVMIKGCTMGPKKRVLTLRKSLLPSFKKKQM EKINLKFIDTASKFGHGRFQTFEEKNNFMGPLKKDR-KEATA------------------ ------------------------------------------------------------ --------------------------MAPRKKVTKTPTRMITKDIGGD-KNGGKRTIRIS RMSRYYPTEDRPRKLRST--KTAFSSHKHTVRSSITPGTVLIIVAGRHKGKRVVFLKQLN -SGLLLVTGPFHLNGCPLRRINQIYVIATKTKVDISGVKLPDRLNDAYFKRQKL-RRPRH T---EG-EIFD-TKKEVYQVSDERKQDQVDVDKQVLEAIRKNKEKKLLFGYLGAMFSLGN KQYPHEMIFMGRVIRAQRKGPGGIFKAHTRTRKGKAALRPVDFAERHGYIKGVIRDIIHD PGRGAPLAKVAFRDPYKYRQRTETFVAAEGMYTGQFVYCGKKASLQIGNILPVGVMPEGT IVCCLEEKAGDRGKLARASGNYATVISHNPDTKKSRVKLPSGSKKVIPSANRAMVGIVAG GGRIDKPMLKAGRAYFKYKVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVRRDTPA GRKVGLIAARRTGRLRGTKQVT-KPGEKD-XXRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGKKKARVDEFSLCVHLVSDEYEQLSSEALEASRICANKYLVKNCGKDSFHLRMR VHPFHVCRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPIMSCRARETNQAAVIE ALRRAKFKFPGRQKIFVSKKWGFTKWEKDVYEEMRQDGRLIPDGVNCQYKPNKGPLSAWK SLTAARLS------------------------------------------------MAAE SDTWKNNVMRQLRIVKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIR RNETIAVHCTVRGAKAEEILERGLKVREYELRKNNFSATGNFGFGIQEHIDLGIKYDPSI GIYGMDFYVVLGRPGFNISQRRRRKSKIGCQHKVNKEESMKWFQQKYDGIILPGK----- --------MPPKFDPTAIKVVYVKAVGGEVPATSSLAPKIGPLGLSPKKIGDDISKSTQE WKGLKITVKLVVQNRQAKVEVVPSASSLVIKALKEPPRDRKKVKHVKHNGNISMDEIIRI ARIMRPRSMARNLAGTCKEILGTAQSVGCSVEKCPPHDVIDKINSGEIEVPDEMTR--YS SEPENPTKSAKARGSYLRVHFKNTRETAQAIKRMHISRATKYLKNVIDKKECIPFRRFNG GVGRNAQTKPFKASQGRWPKKSAEFLLQLLKNAESNAEYKGLDTDHLVIEHIMVNEAPKM RRRTYRAHGRINPYMSSPCHIEVILAEREQAVPRPGPGEDE-PVKKKVS-QKK-LKRQK- MMMRD-MGKFMKQGKVVLILNGRFAGRKAVIVKNYDDGTQEKGYGHALVAGIDRYPRKVT RDMGKKKTKDRSKMKTXMRVYNYNHLMPTRYSV-DVNLDKTSVNKDAFRDPALKRKARRD VKAKFEERYKTGKNRWFFQKLRFMAPR-KGAGKGDKKKQTINEVITKECTINVHKRIHGI GFKKRAPRAIKAVRKFAEKMMGTPDVRIDTRLNKHVWSQGVRNVPYRVRVRLARKRNDDE DSTNRFYTLVTYVPCASFKGTQTINVDNE--XXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXMAANKTFIIKRLLGKKQKQNRPIPQWVRMKTG NKIRYNAKRRHWRRTKLGL----M-A--SDDELACIYAALILADDNVTITDDKLATILKA AKVN-VEPYWPGLFAKALDGVNVRDLITNIGNSA-GSGGPAAGGAAS-APAA-------- -EEKKEEKKEE----KKVESEE-SDDDMGFGLFDXXXXXNKRRNKGGKKGAKKKVVDPFT KKDWYDVKAPSMFVVRQIGKTLVTRTQGTKIASDGLKGRVFEISLA-DLQND---EVSFR KFKLMAEDVQGRNVLTNFHGMDLTRDKLCSMVKKWQTLIEAHVDVKTTDGFLLRMFCIGF TKKKQYQVKKTCYAQHTQVKTIR-KKMVDIITREVSSNDMKEVVNKLIPDSIGKDIEKAC QGIYPLHDVFIRKVKVLKKPKFDLGKLMELHGEG-GAKTVTTESGEQ-------VTRP-- EGYEPPVLESVMGYRG-RRKSMKRLTAPKSWMLDKLSGVFAPRPSTGPHKLRECLPMIVF LRNRLKYALTYDEVKKIVNQRLIKVDGKVRTAKDYPAGFMDVITIEKTNENFRLLYDVKG RFTVHRIKPEEAKYKLCRVKRVTVGAKGVPMLTTHDARTIRYPDPLAKVNDTIMVDIATG KMKEFIKFDSGNLCMITGGHNLGRVGVIQHRERHPGSFDIVHIKDALGHTFATRLSYVFV IGKGNKPWISLPRG-KGVKLSIAEERDRRMAAKSS--XXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXERLTCSLMMHGRNNGKKLMAMRIVKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREASFRNIKTIAECLA DELINAAKGSSNSHAIKKKDELERVAKSNR-----------MYSASA-KIIKPQGEKPDD FEQSVSQALLELEMNSDLKAQLRELYISGAKEIDVAG-KKAIIIFVPVPQLRQYQ-KIQT RLVRELEKKFSGKHVVFIAQRRILPKPTRKTRRK-NKQKRPRSRTLTAVHDCILDDLTFP AEIVGKRIRIKLDGSRLIKVHLDKTQQTNIEHKMDTFTAVYKKLTGKDVTFEFP-EYVL- ---MPRVPIVTSKTYTTPRRPFEKERLDQELKLIGEYGLRNKREVWRVKYTLTKIRKAAR ELLTLDEKDTKRLFEGNALLRRLVRIGVLDETKMKLDYVLGLRLEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSYMVRLDSQKHIDFSLRSPYGGGRPGRVKRKNM KKGSGGG----GDEDEDMLMPKKNRVQIYEYLFKEGVLVAKKDFGAPKHPEID---VPNL HVIKALTSLKSQGYVREQFAWRHFYWYLTNEGIQYLRDFLHLPAEIVPATLKRQTRPETA RPRPKGPEGP-QRGSG-----PSDRSEYRRAPPSS-----DKKAEVGPGADPQFQFRG-G F-GRGK-----------PAQ--------MASDTEGDDVP-----------TAGSMDIYTA LQEVLKTSLIHDGLARGLHECAKALDKRQAHMCILANNCDEATYVKLVEALCAEHGINIM KVDDNKKLGEWAGLCKIDKEGKARKVVGCSCVVVKDYGKDSQALDVMNEYFRSKNK---- -------MADQ-ETQDLLEKKKKRTFRKYTFRGVDLDQLLDMSSEQLMELLSARARRRFS RGLKRKPMALIKRLRKAKKEAKPLEKPEVVKTHLRNMIIVPEMIGSVIGVYNGKTFNQIE VKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMAPVKGG------PLQSVQVY GRKKTATAVAHCKRGNGLIKVNGRPLENIEPQILRAKLQEPLLLLGKEKFAGVDIRVRVR GGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILISYDRTLLVADPRRCEPKKFG GPGPRARYQKSYR-----MARVRTKTVKKAARVIIEKYYTKLTLDFHTNKRVCEEIAILP SKKLRNKVAGFVTHLMKRIQAGPVRGISIKLQEEERERRDNYVPEVSLLEQHDVIEVDPD TKDMLKSLDFGNIPGLQVTQPITAQGGFRPGGAGGPRM---------------------M SL-----KDSKAP--A-EEAP----IHRIRITLTSRNVQSLEKVCADLIKGAKDKQLKVK GPVRMPTKVLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAKKRKKKNYTTPKKNKHKKKKVTLA VLKYYKVDENGKITRLRRECPNDDCGAGVFMASHFDRQYCGKCCLTFVFNKPEDK----- -----MQLFVRGTK-------THTLQIAGD-ETVQDVKTFLNGTEGFP-CEEQVILYAGK --PLSD--NVKLIS-FDDLATLECDVRMLGGKVHGSLARAGKVKGQTPKVEKQEKKK-AX TGRAKRRMQYNRRFGVTVA-TFGRRKGPNANS--------- >Crassostrea MSHRKFSAPRHGSKAFLPKKRSRRHRGKCKSFPKDDKSKPCHLTAFLGYKAGMTHIVREV DRPGSKSNKKEIVEAVTILETPPMMIVGVVGYIETPKGLRAFKTVFAEHLSEDCRRRYYK NWYRAKKKAFTKYSKKWQDEAGKKEIERDFAKMKKYCKVIRVIVHTQMKLLKKRQKKAHI MEVQVNGGTVSQKVDWAKEKLEKAVNIDQVFSQDENIDCIGVTRGRGFKGVTSRWHCKKL PRKTHKGLRKVACIGAWHPSRVQYSVARAGQKGYHHRTEINKKIYRIGKGIHTKDGKVIK NNAATEYDPADKSITPMGGFPHYGEVNQDYVMIKGCCMGSKKRVITLRKSLLATFRKKAM EKINLKFIDTSSKYGHGRFQTFEEKKNFLGPLKKDAQKEAA---------------XXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXKAAKPKAAAAKPAAKKQTQTRLVKKTIGGD-KNGGHRLVRKT RMSRYYPTEDKPRKLRSR--KTAFSKHKHSLRSSITPGTVLILVAGRHKGKRVVFLKQLD -SGLLLVTGPFHLNGCPLRRINQIYTIATKTKLDISGVKLPERLNDKYFNRKQL-KKPRH T---EG-EIFD-TKKEVYTVSDERKEDQVAVDKQILDVIRKNTEKKMLFGYLGSMFSLGK RQYPHKMVFXGQAKSTKKKAPKRIFKARTKNRKGKAALRAVDFAERHGYIKGVVKDIVHD PGRGAPLAKVVFRDPYRYRLRTETFIASEGMYTGQFLYCGKKANLQIGNILPVGAMPEGT IVCCLEEKMGDRGKIARASGDYATIISHNPDTKKSRVKLPSGSKKLIPSANRAMVGIVAG GGRIDKPMLKAGRAYFKYKAKRNCWPKVRGVAMNPVEHPHGGGNHQHIGKASTVRRDTSA GRKVGLIAARR-------------------MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKARVDDFPLCVHLVSDEYEQLSSEALEAGRICANKYLVKNCGKDAFHMRMR VHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPIMSVRARENHQGSVIE ALRRAKFKFPGRQKIHVSKKWGFTKWDRPQYEEMRADGRLIPDGVNVQYKPNKGPLKAWM DRQRV-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKDKSK KKEKKQNVMRELRIQKLCLNICVGESGDRLTRASKVLEQLTGQQPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILERGLKVREYELKKNNFSDTGNFGFGIQEHIDLGIKYDPGI GIYGMDFYVVLSRPGFNIAYRRQRKSKIGPQHKISKEEAMKWFQQKYDGIILPGK----- --------MGPKFDPTAITIVYVKAVGGEVPATSSLAPKIGPLGLSPKKIGDDIAKGTAD WKGLKITVKLVVQNRQAKVEVVPSASSLLIKSLKEPPRDRKKVKHVKHSGNLSMDDVIAI ARQMRPRSMAKNLAGNMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVR--YA TEPDNPTKSAKARGSYLRVHFKNTRETAQAIKRMHVKRATRYLKNVMAKKEVVPFRRFSG GVGRCAQAKAFKHSQGRWPSKSAEFLLQLLKNAESNAEYKGLDTDHLVIEHIMVNAAPKM RRRTYRAHGRINPYMSSPCHIELILAEREQAVPRPGTTDDE-PVKKKVS-QKK-LKRQK- MMMRD-----MKPGKVVLVLSGRFAGRKAVIVKNHDDGTQDKPYGHALVAGIDRYPRKVT RKMGKKKMKDRSKLKAFLRVYNYNHLMPTRYSV-DVNLDKSAVNKDAFRDPALKRKARRD VKAKFEERYKTGKNKWFFQKLRFMAPRTKGSKKGDKK--VLTEVITKECTIHMHKRIHGI GFKRRAPRAIKEIRKFAEKMMGTPDVRVDTRLNKHIWSQGVRNVPYRVRVRLARKRNEDE DSVHRLYTLVTXVPCASFKGTQTINVDXE--MVQRLTFRRRLSYNTKSNSRRVSKTPGGK LVYLYTKKPGSVPK--CGDCKVKLHGITPARPLKLMSMSRRLKTVTRCYGGTRCHRCVRE RIVRAFLIEEQKIVVRVLKAQEASKK---------------------------------- ----------------MPQQIMEIKDFLLTARRKDAKSVKIKKNKENV-KFKVRCSRYLY TLVIQ-DREKAEKLRQSLPPGLAVKDLKMGAHKSYRTKMRLAKKQKQNRPVPKWVRMKTG NTIRYNAKRRHWRRTKLKM----M-A--SSDELACVYAALILADDQVAITSDKIATILKA AGVS-VEPYWPSLFSKALDGVNVKEMISNIS-SG-AGAAPAAAAA----PAAQAAAPA-- -DDKKAAKKEE----KKEE-SE-SDEDMGFGLFDMAVGKNKRLTKGGKKSSKKKVVDPFT KKDWYDVKAPSMFVVRQIGKTLVTRTQGTRIASDGLKGRVFEVSLA-DLQND---EVSFR KFKLMAEEVQGRNVLTNFHGMDLTRDKLCSMVKKWQTMIQAHVDVKTTDGYLLRMFCIGF TKKKQFQVKKTCYAQTTQIKTIR-RKMVDIITKEVTSNDMKEVVNKLIPDSIGKDIEKAC QGIYPLHDVFIRKVKVLKKPKFDIGKLMEMHGEG-GSKTVITDSGET-------VARP-- EGYEPPVQQSVMGYRG-RKKVLKRLTAPKSWMLDKLGGVFAPRPSTGPHKLRESLPLIVF LRNRLKYALTYDEVKKITMQRLIKVDAKVRTDKNFPTGFMDVISIEKTNENFRLLYDVKG RFTVHRIQKEEAKYKLCRVRKVGVAAKGVPYITTHDGRTIRYPDPLVKVNDTVMLDIGTG KIKDFIKFDSGNLCMVTGGHNLGRVGVIQHRERHPGSFDIVHIKDSVGHTYATRLSYVFV IGKGNKPWISLPKG-KGVKLSIAEERDRRLAAKTS------------------------- ----TMTENWDEPAP-AVELPEIKLFGKWSSDDVQVSDISLTDYIAVKEKYAKYLPHSSG RYQVKRFRKSQCPIVERLTCSLMMHGRNNGKKLLTTRIVKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREASFRNIKTIAECLA DELINAAKGSSNSHAIKKKDELERVAKSNRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXMLMPKKNRVLIFEYLFKEGVLVAKKDFSAPKHPEID---VPNL HVIKALTSLKSQGYVREQFSWRHYYWYLTNEGIQYLRDYLHLPAEIVPATLKRQTRPETA RPRPKGPDGP--RGAP----GAQDRAEYRRTAPGG-----DKKADVGAGADPSFQFRG-G F-GRGRGSSAA------PPQ--------M-SDAEGDDVP---------VASGGSMDVFTA VQEVLKTALIHDGLAKGLHECAKALDKRQAHLCILANNCDEPMYVKLVEALCAEHGINLM KVDDNKKLGEWAGLCKIDKEGKARKIVGCSCVVVKDYGKESQALDVLNDYFRSKK----- -------MAEVDEKELA-EKKKKRTFRKYAYRGVDLDQLLDMSNEQLMELFPCRARRRIS HGLKRKPLGLIKRLRKAKKEAGPLEKPEVVKTHLRNMIIVPEMIGSIIGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMEPSTQKG-----PQQSVQVF GRKKTATAVAHCKRGNGLIKVNGRPLEQVEPQILRCKLQEPILLLGKEKFAGVDIRVRVR GGGHVAQVYAIRQAISKSLVAYYQKYVDEASKKEIKDVLISYDRTLLVADPRRCEPKKFG GPGARARYQKSYR-----MARVRTKTVKKAARVIIEKYYTKLTLDFHTNKRVCEEIAILP SKKLRNKVAGFVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEISYIDQHDIIEVDPD TKEMLKALDFGNLQGLQVTQPITAVQGYRQPRM--------------------------M SHF----KDSKAP--Q-EEAP----IHRIRITLTSRNVKSLEKVCADLIKGAKEKSLKVK GPVRMPTKILRITTRKTPCGEGSKTWDRYQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KPRGLRTARKCVNHRRDQKWHDNDYKKAHLPSRWVK-PFQGSSHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNYVEENDEVLVAGFGRK GHAVGDIPGVRFKIVKVANVSLLALFKGKKERPRSXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXMQLFVRGSE-------THALQLAGN-ETVSDIKNLISXXEGFP-VEEQIILYAGK --PLQD--EYXLTK-LNDLSTLDIEVRMLGGKVHGSLARXGKVKGQTPKVEKQEKKK-QK TGRAKRRMQYNRRFGVVVS-TFGRRKGPNANS--------- >Mytilus MSHRKFSAPRHGSKGFLPKKRAKRHRGKVKSFPNDDKNKPVHLTAFIGYKAGMSHIVREV DRPGSKSHKKEIVEAVTILEAPPMMVVGVVGYIETPSGLRAFKTIFAEHLSEECKRRFYK NWYRSKKKAFSKSAKKWQDEAGKKEIERDFNKMKKYCRVIRVLAHTQTKLMKKRQKKAHI MEIQVNGGTISQKVDWAREYFEKSIPVKNVFAQDENIDIIGVTKGKGVKGVTSRWHCKKL PRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEINKKIYRLGDGYHTKEGKLIT SNGSTEYDADEKPITPMGGFPHYGEVSNDFVMVKGCCVGPKKRVVTLRKSLLASFKKKQM EKIDLKFIDTASKFGHGRFQTFKEKHNFMGPLKKDAVAKTEAS----------------- ------------------------------------------------------------ -----------------------------MAPKAKKPARMVTKEVGGD-KNGKKRLVRIN RLPRFYPTEDKPRKLRSR--RKPFSQHKHKIRSSITPGTVLIIVAGRHKGKRVVYLKDLP -SGLLLVTGPFHLNGCPLRRINQQYVIATKTKIDIGSIKLPERVNDKYFARQKL-RKPRH T---EG-EIFD-TKKEVYQVSDERKEDQVSVDKQVLDAIRKNKDKKYLFGYLGAMFSLQN RQFPHQMVFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKAAVDEFPLCVHLVSDELEQLSSEALEAGRICANKYLVKHCGKDSFHLRMR VHPFHVLRINKMLSCAGADRLQTGMRGAYGKPQGTVARVKIGQPLMSVRARDNHKAPVIE ALRRAKFKYPGRQKIYVSKKHGFTKWERGTYEEMRLDGRLIPDGVGAQYKPDHGPLKAWK DRQ-------------------------------------------------------MA DKDKKKNVMRDLRIVKLCINICVGESGDRLTRAAKVLEQLTGQTPVLSKARYTVRSFGIR RNETIACHCTVRGAKAEEILEKGLKVREYELRKNNFSQTGNFGFGIQEHIDLGIKYDPGI GIYGMDFYIVLGRAGFNIAQRRRRKSKIGPNHKVYKEESMKWFQQKYDGIILPGK----- --------XXXXXXXXXXXXXXXXXVGGDCPATSALAPKIGPLGLSPKKVGDDIAKSTAD WKGLKITVKLTVQNRQAKCEVVPSAASLLIKALKEPPRDRKKVKHVKHNGNITFEEVIKI ARQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVR--YA TEPDNPTKSAKARGSYLRVHFKNTRETAQAVKHMHVKRATRYLKNVMGMKECVPFRRFNH RVGRTAQAKQFKTTQGRWPKKSAEFLLQLLKNAESNAEYKGLDVDHLVIEHIMVNEAPKM RRRTYRAHGRINPYMSSPCHIEVILAEREIAVPKPGGTEEE-PTKKKVS-QKK-LKKQK- MXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXIPEFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDE DSPNKLYTLVTYVPVTTFKNLQTVNVDEN--XXXXLTFRRRLCYNTNSSRRTVSKTPGGK LVYLYTKKAGAVPK--CGDCKVKLHGLTPARPQELSSMSKRLKSVTIAYGGSRCHRCVRQ RIIRAFLIEEQKIVGSGAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXMPQQIMEIKDFLLTARRKDAKSVKIKKNKENV-KFKVRCSRYLY TLVIQ-DREKAEKLRQSLPPGLAVKDLKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXX----M-A--SKDELACVYAALILADDEVAVTAEKLKTILKA SGVS-VEPYWPGLFSKALESVNVKELITNIS-SGVG-AAPAAGA-----PAAAAEAAP-- AKGA-DKKKEE----KKAESEE-SDDDMGFGLFDXXXXKDKRLTKGGKKGGKKKVVDPFT KKDWYDVKAPCMFVVRQIGKTLVTRTQGTKIASDGLKGRVFEISLA-DLQND---EVSFR KFKLMAEDVQGRNVLTNFHGMDLTRDKLCSMVKKWQTLIEANVDVRTTDGYLLRMFCIGF TKKKAMQNKKTCYAQHTQIKTIR-KKMVDIITKEVSTNDMKEVVNKLIPDSIGKDIEKAC QGIYPLHDVYVRKVKVLKKPKFDLGKLMELHGEGSASKTVITESGET-------VERP-- EGYEPPVLQSVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXKIVHQRLIKVDGKVRTDMTFPAGFMDVVTIDKTQENFRLLYDVKG RFAVHRIKSEEAKYKLCRVKKVGVALKGVCYVVTHDGRTIRYPDPLVKVNDTIMVDIATG KIKDFIKFDSGNLCMITGGHNLGRVGVIQHRERHPGSFDIVHIKDSLGHSFATRLSYVFI IGKGNKPYVSLPRG-KGVKLSIAEERDRRMAAK--------------------------- -----MAESWDEPAPAVAELPEIKLFGKWSSDDVQVSDISLTDYIAVKEKYAKYLPHSAG RYQMKRFRKAQCPIVERLVCSLMMHGRNNGKKLLAMRIVKHAFDIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGARDTSFRNIKTIAECLA DELINAAKGSSNSHAIKKKDELERVAKSNRXXXXXXXXXXXXYSASA-KIVKPQGEKPDE FEQSISQALLELEMNSDLKQQLRELYITGAKEIDVAG-KKAIIIFVPVPQLRSYQ-KIQT RLVRELEKKFSGKHVVFIAQRRILPKPTRKTRRK-NKQKRPISRTLTSVHDAILDDLTFP AEIVGKRIRIKLDGSRLIKVHLDKTQQTNIEHKLDTFGAVYKKLTGKDVNFEFP-EYVL- -XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXMLMPKKNRVTIFEYLFKEGVLVAKKDFGAPKHPDID---VPNL QVIKALTSLKSQGYVREQFAWRHFYWYLTNEGIEYLRNYLHLPAEIVPATLKRQTRQEAP RPRPKGPDGP-SRTPG----GGADRAEYRRAAPGGGD---DKKADVGAPADGKFQFRG-G F-GRGKPSQ--------PPQ--------MASDTEGDDVP---------MAAGGVMDIYTA LQEVLKTSLIHDGLARGLHECAKALDKRQAHLCILANNCDEPAYVKLVEALCTEHGINLL KIDDSKKLGEWAGLCKIDREGKARKVVGCSCVVVKDYGKESQALDVLHEYFRSKK----- -------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMSNEQLMELFPCRIRRRLS KGLKRKPMALIKRLRQAKKEAGPLEKPEVVKTHLRNMIIVPEMIGSIIGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMPPKG--------PLQSVQVY GRKKTATAVAHCKRGTGLIKV-GRPLDLLEPQVLRYKLQEPVLLLGKEKFAGVDIRVRVK GGGHIAQIYAIRQAISKSLVAYYQKYVDEASKKEIKDMLISYDRTLLVADPRRCEPKKFG GPGPRARYQKSYR-----MARVRTKKVKKAARVIIEKYYTKLTQDFHTNKRVCEEIAILP SKKLRNKVAGFVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEISFIDQNDIIEVDPD TKEMLKALDFGNLQGLQVTQPVSSVQRGFSGPNRPN-----------------------M SY-----KEGKAP--ASEEAT----IHRIRITLTSRNVKSLEKVCADLIKGAKEKSLKVK GPVRMPTKVLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KPRGLKTARKQRNHRREQKWHDKDYKKAHLPSRWCK-PFQGSSHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNYVEENDEVLVAGFGRK GHAVGDIPGVRFKIVKVANVSLWALFKGKKERPRTAKKRKKKNYTTPKKNKHKKKKVKLA VLKYYKVDENGKITRLRRECPNEECGAGVFMANHFDRQYCGKCCLTYVFNKPEATKK--- -----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX >Homo MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA-------------MAGE KVEKPDTKEKK---PEAKKVDAGGKVKKGNL---------KAKKPKKGKPHCSRNPVLVR GIGRYSRSAMYSRKAMYKRKYSAAKSKVE-KKKKEKVLATVTKPVGGD-KNGGTRVVKLR KMPRYYPTEDVPRKLLSHG-KKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLA -SGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKL-RKPRR Q---EG-EIFD-TEKEKYEITEQRKIDQKAVDSQILPKIKAIPQ---LQGYLRSVFALTN GIYPHKLVFMGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHD PGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGT IVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAG GGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPA GRKVGLIAARRTGRLRGTKTVQ----EKENMGRRPARCYRYCKNKPYPKSRFCRGVPDAK IRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIE ALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWR ALHS-----------------------------------------------------MAQ DQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK----- --------MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGD WKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNI ARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPASMVR--YS LDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNG GVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKM RRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKP---EEEVAQKKKIS-QKK-LKKQK- LMARE-MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVT AAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSV-DIPLDKTVVNKDVFRDPALKRKARRE AKVKFEERYKTGKNKWFFQKLRFMAPA-KKGGEKKKGRSAINEVVTREYTINIHKRIHGV GFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDE DSPNKLYTLVTYVPVTTFKNLQTVNVDEN--MVQRLTYRRRLSYNTASNKTRLSRTPGNR IVYLYTKKVGKAPKSACGVCPGKLRGVRPVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRD RIKRAFLIEEQKIIVKVLKAQAQSQKAK-------------------------------- ----------------MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNV-KFKVRCSRYLY TLVIT-DKEKAEKLKQSLPPGLAVKELKMSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTG NKIRYNSKRRHWRRTKLGL----M-A--SVSELACIYSALILHDDEVTVTEDKINALIKA AGVN-VEPFWPGLFAKALANVNIGSLICNVG-AG-G-PAPAAGAA----PAGGPA-PSTA AAPAEEKKVEA----KKEESEE-SDDDMGFGLFDMAVGKNKRLTKGGKKGAKKKVVDPFS KKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLA-DLQND---EVAFR KFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGF TKKRNNQIRKTSYAQHQQVRQIR-KKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKAC QSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSS-SGKATG-DETG----AKVERA-- DGYEPPVQESVMA-RGPKKHL-KRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIF LRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKG RFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETG KITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFV IGKGNKPWISLPRG-KGIRLTIAEERDKRLAAKQSSG----------------------- ------MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAG RYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MFSSSA-KIVKPNGEKPDE FESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQ-KIQV RLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTK-NKQKRPRSRTLTAVHDAILEDLVFP SEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFP-EFQL- --MPVARTWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAR ELLTLDEKDPKRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNA KKGQGGAG-AGDDEEEDMLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNL HVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRR-SRPETG RPRPKGLEGE--RPARLT-RGEADRDTYRRSAVPPGA---DKKAEAGAGSATEFQFRG-G F-GRGRGQ---------PPQ--------MAEEGI---------------AAGGVMDVNTA LQEVLKTALIHDGLARGIREAAKALDKRQAHLCVQASNCDEPMYVKLVEALLAEHQINLI KVDDNKKLGEWVGLCKIDREGNPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK----- -------MAEVEQ-------KKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLN RGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMPSKG--------PLQSVQVF GRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVK GGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFG GPGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIP SKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQ-EIIEVDPD TKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV-------------------------M AF-----KDTGKT--PVEPEVA---IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRSAKKRKKKSYTTPKKNKHKRKKVKLA VLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK----- ------------------------------------------------------------ ------------------------------MKVHGSLARAGKVRGQTPKVAKQEKKK-KK TGRAKRRMQYNRRFVNVVP-TFGKKKGPNANS--------- >Mus MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDASKPVHLTAFLGYKAGMTHIVREV DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK NWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHL MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRAL EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA-------------MAGE KA--PDTKEKK---PAAKKAGSDAAASRPRAAKVAKKVHPKGKKPKKAKPHCSRNPVLVR GIGRYSRSAMYSRKALYKRKYSAAKTKVEKKKKKEKVLATVTKTVGGD-KNGGTRVVKLR KMPRYYPTEDVPRKLLSHG-KKPFSQHVRRLRSSITPGTVLIILTGRHRGKRVVFLKQLD -SGLLLVTGPLVINRVPLRRTHQKFVIATSTKVDISDVKIPKHLTDAYFKKKQL-RKPRH Q---EG-EIFD-TEKEKYEITEQRKADQKAVDLQILPKIKAVPQ---LQGYLRSQFSLTN GMYPHKLVFMGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHD PGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGT IVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAG GGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPA GRKVGLIAARRTGRLRGTKTVQ----EKENMGRRPARCYRYCKNKPYPKSRFCRGVPDAK IRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIE ALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWR ALHS-----------------------------------------------------MAQ DQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK----- --------MPPKFDPNEVKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGD WKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNI ARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPASMVR--YS LDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNG GVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKM RRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKP---EEEVAQKKKIS-QKK-LKKQK- LMARE-MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVT AAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSV-DIPLDKTVVNKDVFRDPALKRKARRE AKVKFEERYKTGKNKWFFQKLRFMAPA-KKGGEKKKGRSAINEVVTREYTINIHKRIHGV GFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDE DSPNKLYTLVTYVPVTTFKNLQTVNVDEN--MVQRLTYRRRLSYNTASNKTRLSRTPGNR IVYLYTKKVGKAPKSACGVCPGRLRGVRAVRPKVLMRLSKTQKHVSRAYGGSMCAKCVRD RIKRAFLIEEQKIVVKVLKAQAQSQKAK-------------------------------- ----------------MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNV-KFKVRCSRYLY TLVIT-DKEKAEKLKQSLPPGLAVKDLKMSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTG NKIRYNSKRRHWRRTKLGL----M-A--SVSELACIYSALILHDDEVTVTEDKINALIKA AGVS-VEPFWPGLFAKALANVNIGSLICNVG-AG-G-PAPAAGAA----PAGGAA-PSTA AAPAEEKKVEA----KKEESEE-SEDDMGFGLFDMAVGKNKRLTKGGKKGAKKKVVDPFS KKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLA-DLQND---EVAFR KFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGF TKKRNNQIRKTSYAQHQQVRQIR-KKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKAC QSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGS-SGKAAG-DETG----AKVERA-- DGYEPPVQESVMA-RGPKKHL-KRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIF LRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKG RFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETG KITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFV IGKGNKPWISLPRG-KGIRLTIAEERDKRLAAKQSSG----------------------- ------MTEWEAATPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAG RYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MFSSSA-KIGKPNGEKPDE FESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQ-KIQV RLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTK-NKQKRPRSRTLTAVHDAILEDLVFP SEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFP-EFQL- --MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAR ELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNA KKGQGGAG-AGDDEEEDMLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNL HVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRR-SRPETG RPRPKGPEGE--RPARFT-RGEADRDTYRRSAVPPGA---DKKAEAGAGSATEFQFRG-G F-GRGRGQ---------PPQ--------MAEEGI---------------AAGGVMDVNTA LQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLI KVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK----- -------MAEVEQ-------KKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLN RGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMPSKG--------PLQSVQVF GRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVK GGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFG GPGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIP SKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQ-EIIEVDPD TKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV-------------------------M AF-----KDTGKT--PVEPEVA---IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRSAKKRKKKSYTTPKKNKHKRKKVKLA VLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK----- -----MQLFVRAQE-------LHTLEVTGQ-ETVAQIKDHVASLEGIA-PEDQVVLLAGS --PLEDEATLGQCGVEA-LTTLEVAGRMLGGKVHGSLARAGKVRGQTPKVAKQEKKK-KK TGRAKRRMQYNRRFVNVVP-TFGKKKGPNANS--------- >Rattus MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK NWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHL MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRAL EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA-------------MAGE KA---EKPDKKEQKPAAKKAGGDATAPRAPPAGAVKKSSSKAKKLRKSKPHCSRNPVLVR GIGRYSRSAMYSRKALYKRKYSAAKTKVEKKKKKEKVLATVTKTVGGD-KNGGTRVVKLR KMPRYYPTEDVPRKLLSHG-KKPFSQHVRRLRSSITPGTVLIILTGRHRGKRVVFLKQLG -SGLLLVTGPLALNRVPLRRTHQKFVIATSTKVDISKVKIPKHLTDAYFKKKPL-RKPRH Q---EG-EIFD-TEKEKYEITEQRKADQKAVDSQILPKIKAVPQ---LQGYLRSQFSLTN GMYPHKLVFMGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHD PGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGT IVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAG GGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPA GRKVGLIAARRTGRLRGTKTVQ----EKENMGRRPARCYRYCKNKPYPKSRFCRGVPDAK IRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIE ALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWR ALHS-----------------------------------------------------MAQ DQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK----- --------MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGD WKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHNGNITFDEIVNI ARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPASMVR--YS LDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNG GVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKM RRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKP---EEEVAQKKKIS-QKK-LKKQK- LMARE-MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVT AAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSV-DIPLDKTVVNKDVFRDPALKRKARRE AKVKFEERYKTGKNKWFFQKLRFMAPA-KKGGEKKKGRSAINEVVTREYTINIHKRIHGV GFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDE DSPNKLYTLVTYVPVTTFKNLQTVNVDEN--MVQRLTYRRRLSYNTASNKTRLSRTPGNR IVYLYTKKVRKAPKSACGVCPGRLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAQCVRD RIKRAFLIEEQKIVVKVLKAQAQSQKAK-------------------------------- ----------------MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNV-KFKVRCSRYLY TLVIT-DKEKAEKLKQSLPPGLAVKELKMSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTG NKIRYNSKRRHWRRTKLGL----M-A--SVSELACIYSALILHDDEVTVTEDKINALIKA AGVN-VEPFWPGLFAKALANVNIGSLICNVG-AG-G-PAPAAGAA----PAGGPA-PSAA AAPAEEKKVEA----KKEESEE-SEDDMGFGLFDMAVGKNKRLTKGGKKGAKKKVVDPFS KKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLA-DLQND---EVAFR KFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGF TKKRNNQIRKTSYAQHQQVRQIR-KKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKAC QSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGS-SGKTTG-DETG----AKVERA-- DGYEPPVQESVMA-RGPKKHL-KRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIF LRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKG RFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETG KITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFV IGKGNKPWISLPRG-KGIRLTIAEERDKRLAAKQSSG----------------------- ------MTEWETATPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAG RYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MFSSSA-KIVKPNGEKPDE FESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQ-KIQV RLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTK-NKQKRPRSRTLTAVHDAILEDLVFP SEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFP-EFQL- --MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAR ELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNA KKGQGGAG-AGDDEEEDMLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNL HVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRR-SRPETG RPRPKGPEGE--RPARFT-RGEADRDTYRRSAVPPGA---DKKAEAGAGSATEFQFRG-G F-GRGRGQ---------PPQ--------MAEEGI---------------AAGGVMDVNTA LQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLI KVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK----- -------MAEVEQ-------KKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLN RGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMPSKG--------PLQSVQVF GRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVK GGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFG GPGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIP SKNLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQ-EIIEVDPD TKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV-------------------------M AF-----KDTGKT--PVEPEVA---IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRSAKKRKKKSYTTPKKNKHKRKKVKLA VLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK----- -----MQLFVRAQE-------LHTLEVTGQ-ETVAQIKAHVASLEGIA-PEDQVVLLAGS --PLEDEATLGQCGVEA-LTTLEVAGRMLGGKVHGSLARAGKVRGQTPKVAKQEKKK-KK TGRAKRRMQYNRRFVNVVP-TFGKKKGPNANS--------- >Xenopus MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDASKPVHLTAFLGYKAGMTHIVREV DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK NWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHL MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRAL EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA----------------- ------------------------------------MAGEQQPVKKARKHHCSRNPVLAR GIGKYSRSAMYARKALYKRKFKAPQTKIE--KKKQKALVTVTKTVGGD-KNGGTRVVKLR KMPRYYPTEDVPRKLLSHG-KKPFSQHKRKLRSSITPGTVLILLNGRHRGKRVVFLKQLQ -TGLLLVTGPLAINRVPLRRAHQKFAIATSTKIDISSVKIPKHLTDSYFKKKKL-RKPKH Q---EG-EIFD-TEKEKYAVTQQRKADQKFVDSQLLPLLKKEPQ---LRGYLRSAFFLSN GMYPHKLVFMGRVIRGQRKGAGSVFKAHVKHRKGAAKLRAVDFAERHGYIKGIVKDIIHD PGRGAPLAKVAFRDPYRFKKRTELFVAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGT IVCCVEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAIVGVVAG GGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPA GRKVGLIAARRTGRLRGTKTVQ----EKENMGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKTQNKEHVIE ALRRAKFKFPGRQKIHISKKWGFTKFNADEFESLLAEKRLIPDGCGVKYIPNRGPLDKWR AIHAV----------------------------------------------------MA- DKSDKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSI GIYGLDFYVVLGRPGFSIADKKRKRGTIGAKHRIGKEEAMRWFQQKYDGIILPGK----- --------MPPKFDPTEIKVVFLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGD WKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHNGNISMDEVISI ARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPASMVR--YS LDPENPTKSCKARGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNG GVGRCAQAKQWDWTQGRWPKKSANFLLHILKNAESNAEVKGLDVDSLVIEHIQVNKAPKM RRRTYRAHGRINPYMSSPCHIELILTEKEQIVPKP---EEEVAQKKKIS-QKK-LKKQK- LMARE-MGKFMKPGKVVLVLAGRYAGRKAVIVKNVDDGTSDRQYSHALVAGIDRYPRKVT ATMGKKRIAKRSKIKSFVKVYNYNHLMPTRYSV-DIPLDKAVVNKDVFRDPALKRKARRE AKVKFEERYKTGKNKWFFQKLRFMAPA-KKGGEKKKGRSAINEVVTREYTINIHKRIHGI GFKKRAPRALKEIRKFAVKEMRTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDE DSPNKLYTLVTYVPVTNYKGLQTVNVDEN--MVQRLTYRRRLSYNTASNKTRLSRTPGNR IVYLYTKKVGKAPKSACGICPGRLRGIRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRD RIKRAFLIEEQKIVVKVLKAQAQSQKAK-------------------------------- ----------------MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNV-KFKVRCSKYLY TLVIT-DKEKAEKLKQSLPPGLSVKELKMSSHKTFKIKRFLAKKQKQNRPIPQWIRMKTG NKIRYNSKRRHWRRTKLGL----M-A--SVSELACIYSALILHDDEVSITEDKISTLIKT AGVT-IEPFWPSLFAKALANINIGSLISNVG-AG-G-GAPAAGGA-----APSAA-SAGG AAPAEEKKEEE----KKEESEE-SDDDMGFGLFDMAVGKNKRLTKGGKKGAKKKIVDPFS KKDWYDVKAPAMFNIRNLGKTLVTRTQGTKIASDGLKGRVFEVSLA-DLQND---EVAFR KFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGF TKKRNNQIRKTSYAQHQQVRQIR-KKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKAC QSIYPLHDVYVRKVKMLKKPKFELGKLMELHGEGGG-AGKPAG-DETG----AKVERA-- DGYEPPVQESVMA-RGPKKHL-KRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIF LRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIEKTGEHFRLVYDTKG RFAVHRITAEEAKYKLCKVRKTWVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETG KITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNNFATRLSNIFV IGKGNKPWISLPRG-KGIRLTIAEERDKRLAAKQSSG----------------------- ------MSDWETVPVGS-ETPEIKLFGKWSTDDVQINDISLQDYIAVKEKYAKFLPHSGG RYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECVA DELINAAKGSSNSYAIKKKDELERVAKSNR-----------MFSSSA-KIVKPNGEKPDE FESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQ-KIQV RLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTK-NKQKRPRSRTLTAVHDAILEDLVFP SEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFP-EFQL- --MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAR ELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNA KKGQGGAG-AGDDEEEDMLMPKKDRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNL HVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDFLHLPPEIVPATLRR-SRPETG RPRPKGLEGE--RPPR-LPRGETDRDTYRRSAVPSGA---DKKAEAGAGAATEFQFRG-G F-GRGRGQA--------P-Q--------MAEEGI---------------SAGGVMDVNTA LQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLI KVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKSKK----- -------MAEVEQ-------KKKRTFKKFTYRGVDLDQLLDMSYEQVMQLYCARQRRRLN RGLRRKQNSLLKRLRKAKKEAPPMEKPEVIKTHLRDMIILPEMVGSMVGVYNGKAFNQVE IKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMPAKG--------PLQSVQVF GRKKTATAVAHCKRGNGLIKVNGRPLEMIEPATLQYKLLEPVLLLGKERFAGVDIRVRVK GGGHVAQVYAIRQAISKSLVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFG GPGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIP SKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQ-EIIEVDPD TKEMLKLLDFGGLSNLQVTQPTVGMNFKTPRGTV-------------------------M AF-----KDAGKA--PVDQEVA---IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVE VEVTIADA--MG--KCRGLRTARKLRNHRREQKWHDKQYKKAHLGTALKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRA GHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRSAKKRKKKSYTTPKKNKHKRKKVKLA VLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK----- -----MQLFVRGQS-------LHTLEVSGQ-ETISQIKDQISSLEGIP-SEDQVVVLAGS --PLSEEHTLQQCGVCD-LSTLDIVARLLGGKVHGSLARAGKVRGQTPKVAKQEKKK-KK TGRAKRRMQYNRRFVNVVP-TFGKKKGPNANS--------- >Ciona MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKAFPRDDPSKPCHLTAFISYKAGMTHVVREV DRPGSKVNKKEVVDAVTILEAPPMIVVGVIGYIETPRGLRTLKTLFAEHLSDECKRRFYK NWYACKKKAFTKSCRKWQDEEGKRQIDRDFNQMKKYCKVIRVIAHTQMKLLPITQKKSHI MEIQVNGGTIPEKVDYARDLLEKPVPVSNIFAKDEMIDIIGVNKGHGEKGVTSRWHTKKL PRKTHKGLRKVACIGAWHPARVAYSVARSGQKGYHHRTEVNKKIYRLGAGIHKEGGKLIK NNAATETDITDKSITPMGGFPHYGEVKNDFVMIKGCCIGPKKRVLTLRKSLITHTKRAAL EKINLKWIDTSSKFGHGRFQTHEEKRAFMGPLKKDRLAAAAAAATTTTA----------- ---------------------------------------------------MAKKPHAPR NKPLRKGVNRYSRSVMYAKRYAFKHRKNVTKVEKKMDVTHKLKTIGGD-KNGSTRFVPTK KMPRYYPTEDVPRKLRSHG-KKPFSEHKRKLRSSITPGTVLILLAGPHRGKRVVFLKQLD -TGLLLVTGPHKLNGVPLRRINQVYVIATKTKVDVSGVTIPKRVNDAYFKRKEL-SKPKH G---EG-EIFE-TDEQKYTVSDERKEDQTAVDKQVLAVLGKDEY---MKGYLTGKFSLQT GQYPHNMVFMGRVIRSQRKGPGSIFKAHTTHRKGAAKLRSVDFAERHGYIKGIIKDIVHD PGRGAPLVKVQFQDPYKYRRRLETFVAVEGNFTGQSIYCGKKAQLTIGNVLPVGILPEGT VVCGLEEKTGDRGKLAKTSGNYATIIAHNPDTNRTRVKLPSGAKKLIPSTNRAIIGVVAG GGRIDKPLLKAGAAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGSPSTVRRDASP GRKVGLIAARRTGRLRGSRVSK----DKE-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKRADVRDFPLCMHMVSDELEQLSSEALEAARICANKYMVKYCGKDSFHLRVR VHPFHVVRINKMLSCAGADRLQTGMRGAYGKPQGLVARVKIGQPIMSMRCKDSARAHAIE ALRRAKFKFPGRQKIYDSPKWGFTKWNREDYERMLAEGLLIPDGVSCQYKPNKGKLDLWK KRQ------------------------------------------------------MAE DSAKKPNCMRDIHIQKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR RNEKIACHCTVRGPKAEEILERGLKVREYELRQGNFSKTGNFGFGIQEHIDLGIKYDPSI GIYGMDFYVMLARPGYNVRYRRKKKNRVGFPHRLTKPDGMRWFQQKYDGILLPGK----- --------MPPKFDPTAIHYVYLRVTGGEVGATASLAPKIGPLGLSPKKVGDDIAKSTQD WKGLKITVCLKIQNRQATVSVVPSAASLVIKALKEPPRDKKKVKNIKHNGNITMEDVYGV ARIMRERSMSRFFSGTVKEILGTAQSVGCTVDGKPPHDVIDMINDGEIECPDEMTR--YS QDPENPAKSCKARGSDLRVHFKNTRETAQAIKGMHIRKATQYLKDVCEKKRCIPFRRFNG GVGRCAQAKEFKTTQGRWPKKSATFLLQMLKTAESNADVKGLDVDSLVIDHIQVNAAAKM RRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPRV---EEE-QKKKKVS-KKK-IARQK- LMGKE-MGKFMKPNKVVLILAGRYAGRKGIIVKNQDEGTNDRPYGHALVAGIDRYPRKVT KRMSKKKIKKRNKIKTFVKVVNYNHLMPTRYSV-DVPIDKSSVNKEAIRDATGRRKARRE IKSQFENRYKTGKNKWFFQKLRFMVS--KKEKKGRSGVKAMKDVVTREYTIHMHKRIHGM GFKKRAPRAVKEIRKFALKMMGTSDVRIDTRLNKFVWSQGVRNVPYRIRVRLARKRNEDE DSANKLYTLVTYVPVATFKGLNTVNVDADE-MVQRLTYRRRLSYNTSSNRRRISKTPGGR LVYLHTKKVGSIPK--CGDTKRQLFGIKPARPKELMSMCKRKKHVTRAYGGCLSSKAVRD RIVRAFLVEEQKIVVRVLKAQAKK------------------------------------ ----------------MPKQITEIKDFLLTARRADAKSVKIKKNRQNT-KFKVRCSRYLY TLVIQ-DKDKAEKLRQSLPPGLSVKELKMAANKTFIIKRLLGKKQKQNRPIPQWVRMKTG NKIRYNAKRRHWRRTKLGL----M----STSELACVYASLILSDDQVDITADRISKLLSA ANVT-VEPFWPGLFAKALDGVDIKSLICNVG-SG-S-GAPA-GGA-----AAAEE----- -TKAEVK-EEE----KKEESEEESDDDMGFGLFDMAVGKNKRLTKGGKKGGKKKIVDPFS KKDWYDVKAPAVFKNRQIGKTLVSRTVGTKIAADGLKGRVFECNQA-DLHGD---ESTYR KMKLIVEDVQGKHCLTNFHGMSLTRDKLCSMVKKWQTLIEASCDVSTTDGYKVRMFCIGF THRRSNQIKKTSYAQHMQVINIR-AKMIEIMTREVNLGNLRELVNKLIPDSIAKDIEKAC QGIYPLHDVHIRKVKVLKKPKLDLGRLMEMHGEGSAKTGQSKS--DTG----SKVERSGG DSYEPPVQDSVMA-RGPKKHL-KRLNAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLCIF LRNRLHYALTYDETKRILMQRLVKVDGKVRTDTTYPAGFMDVITIDKTAEYFRLIYDVKG RFAVHRITSDEAKYKLCKVKKVATAPKGVPYLVTHDARTIRYPNPDIKVHDTVVVDIASG KITGFVHLDSGNMCMITGGHNLGRVGTVMHRERHPGSFDIIHVKDALGHTFATRLSNVFI IGQANKPMVSLPRG-KGIKLTIAEERDRRLATK--------------------------- ------MEEDYEADVIVAEAPEVKLFGRWTTSDVQINDISLTDYLPVKDKYSKYLPHSSG RYQIKRFRKAQCPIVERLVNSMMMHGRNTGKKLLTVRIIKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQSVDVSPLRRVNQAIWLLCTGAREASFRNIKTIAECLA DELINAHKGSSNSYAIKKKDELERVAKSNR-----------MFSAGA-KIMKSGNERPDD FESSISQAILELESNSDLKSHLRELYITAAKEVDVGGGRKAAVIFVPVPQLRQFQ-KIQV RLVRELEKKFSGKHVIFIAQRRILPKPTRKTKSK-SKQRRPRSRTLTTVHENILEDLVFP SEIVGKRIRIKLDASRAIHVHLDKSQQTNVEHKIDTFSAVYKKLTGKDVHFEFP-XXXXX X-MPHARRLVYRKTYVTPRRPFEKARLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAAR DLLTLDEKNTRRLFEGNALLRRLVRIGVLDETKMKLDYVLGLKVEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNA KKGSNTN----EEEDEDMLMPKKHRVLIYEHLFKEGVLVAIKDPFLDKHPELES--VPNL HVMKACQSLKSRGYVRENFTWRHYYWILTNEGIQYLRDFLHLPPEIVPSTLKRQPRPTDT RMQRQKVES---RP-----AYQSDRESYRHA--PQGAG--DKKAEAGAGTGG-FDFRGAG Y-GRGRGAA--------PPQ--------M-SDGEGDDVPVAV-------QPSGPMDLNTA LQEVLKTAVINDGLARGLNECARALDKRQAHLCVLANNCDEPSYVKLIEALCNEHQISLI KVDDSKKLGEWAGLCKIDQEGKPRKVVGCSSVVVRDWGKEGQAHDVLAEHLKKV------ -------MADSVP-------KK-RTFRKYTYRGVDLDRLLDMSREQLMDMYCARQRRSFN RGVKRKHNALLKRLRKAKKNTPALEKPEVIKTHLRNMVIEPEMVGSMVGVYNGKVFNQVE IKPEMIGRYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMTSLKT---------QSVQVY GRKKTATAVAHCKRGKGLIKVNGRPIELVEPETLRYKMEEPILLLGKTRFEGVDIRIRVK GGGRVAQVYAIRQALAKSLVAYYQKFVDEASKKEIKDTLIQYDRTLLVSDPRRKESKKFG GAGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIP SKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQ-EIIEVDPD TKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV-------------------------M SAY----KDAGKVPQGEQEVQ----IHKIRITLTSRNVQSLEKVCSDLIKGAKDKQLRVK GPVRMPTKVLRITCRKTPCGEGSKTWDRYQMRIHKRLIDLHSPSEVVKQITSISIEPGVE VEVTIADV--MG--KPSGLRCARKLKNRRRDQKWHDKDYKKSHLGTALKANPFGGASHAK GIVLEKIGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNYIEENDEVLVAGFGRS GHAVGDIPGVRFKIVKVANVSLHALFTGKKERPRSGKKRKKKTYTTPKKIKHKRVKVKLA TLKYYKVDENGKISRLRRECPNTECGAGVFMASHFDRQYCGKCALTYVF-KPENQ----- -----MQIFLKTNE-------LHCVQVDSG-DLVSNLKAQINAIEGIA-TEDQVLSYNGI --TLDDDLSLEAAGLND-LSTVQVLGRVLGGKVHGSLARAGKVKGQTPKVEAQEKKK-KK TGRAKRRMQYNRRFVNVVA-TFGRRRGPNANS--------- >Strongylocentrotus MSHRKFSAPRHGSLGFLPRKRSRRHRGKAKAFPKDDKSKPVHLTCFLGYKAGMTHIVRDV DRPGSKVNKKEVVEAVSILETPPMIIVGLVGYIETPSGLRALKTVWAEHLSDECKRRFYK NWYRSKKKAFTKSSKKWADEMGKKEIEKDLNIMKKYCTVIRVIAHTQMKLMNQRQKKAHV MEIQLNGGSIGDKIEWARERLEKNIPVSEVFGQDELIDIIGVTKGHGFKGVTSRWGTKKL PRKTHKGLRKVACIGAWHPARVGYGVARAGQKGYHHRTEINKKVYRVGKGLXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---- --------------------------------------------MLTMGDDKVKKGHTSR QKWMTGGIPRYSRSQMYKRTAMYKKKKTVVKKERKRQPAMVEKQIGGE-KNGGKRLVRVK RLPRYYPTEDLSRKLNNR--KKPFSMHKSKLRPSITPGTVLILLAGRYKGKRVVFVKQLD -SGLLLVTGPFDLNGVPLRRINQTYVIATQTKLDISSVKVPERLNDLYFKRMKL-KKPRG Q---EG-EMFE-SEKKEYTVSEERKEDQKSVDGQLLTLIKGVDY---MKGYLQMAFSLST KQFPHKMVFMGRVIRGQRKGAGSVFRSHNKHRKGAPRLRSIDYAERHGYLKGIVKEIIHD PGRGAPLARIQFRDPYRYKKRTELMIAPEGMYTGQFIYCGKRATLNIGNVLPLGSMPEGT VICSVEEKAGDRGKLARCSGNYATVVSHNPDTKKSRIKLPSGSKKVVPSANRAMVGVVAG GGRIDKPLLKAGRAYFKYKVKRNCWPRVRGVAMNPVDHPHGGGNHQHIGTPSTVRRDTSA GRKVGLIAARRTGRLRGTKKVK---DSKE-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGKKKTDVDEFPKCVNLVSDEYEQLSSEGLEAARICANKYMIKVAGKDAFHIRMR VHPYHIVRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPLISIRCKDAHEAVAIE ALRRAKFKFPGRQKIFVSKKWGFTKWDRSEYEERRRNGSIKPDGTNVQYFPDKGPLSRWK HMQQQS------------------------------------------------------ --------MRELRIRKLCLNVCVGESGDRLTRAAKVLEALTGQSPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVREYELRKGNFSCTGNFGFGIQEHIDLGIKYDPSI GIYGMDFYVVLGRPGFSVGHKRKRKGRVGSSHRVNKEEAMKWFQQKYDGVLLPGK----- --------MPPKFDPNEIKIVCLRAVGGEVGATSTLAPKIGPLGLSPKKVGDDIAKATQE WKGLKITVMLTIQNRQAKVSVVPSASSLIIRALKEPPRDRKKVKNISHSGNIGLDVIIEI AKTMRERSMARELKGTVKEVLGTAQSVGCTVDGSNPHDIIEQINDGAIEIPAEMTR--YS QEPENSAKSCKARGSYLRVHFKNTRETAQAIKHMHVRKAIRFLKDVTNKKQCVPFRRFNA CIGRKAQAKAWNHTQGRWPKKSAEFLLQLLKNAESNAEYKGLDVDSLVIDHIQVNAAPKM RRRTYRAHGRINPYMSSPCHIELILTEREQVVPKP---EEEEEAKKKVS-KKK-LAKQK- MMARD-MGKFMKAGKVVLVLGGRYAGRKAIIVKNYDDGTQDRPYGHALVAGIDKYPLRVT KPMGKKKVTKRSKIKSFIKVINYNHLMPTRYSV-DVALNKNKVNKDILKDGSKRRRAKTE IKAKLEERYKSGKNKWFFQKLRFMV---KKGGSEKKKRSALNEVVTRDYTIHLHKRIHGV SFKRRAPRAIKEIRTFATKMMGTDDIRIDTRLNKHIWSQGVRSVPFRVRVRLARKRNEDE DSPHKLYTLVTHVAVPSFKGLQTVNVDNQD-MVQRLCFRRRHTYNTKSNKVKIVKTPGGR LVYHYRKKKPSPAR--CGDTGVKLKGVQAARPKKLMALSKPKKKVSRAYGGCLCAKAVKQ RIVRAFLIEEQKIVHRVLKASQGKKK---------------------------------- ----------------MPKEIMEIKDFLLTARRKDAKFVKIKKNRDNT-KFKVRCSRYLY TLVIKKDSEKAEKLKQSLPPGESMLESXMPSHKTFKIKQKLAKKQKQNRPIPQWVRLRTG NRIRYNAKRRHWKRTKLNF----MAAEDNTSELACVYSALILQDDDVPITADKLQTLIKA AGVS-VEPYWPGLFAKALGSIDVSSLISNVG-AGGGGAAAA--------PAGDAGGEAAA ----EEKKEE-----VKDESEE-SDDDMGFGLFDMAVGKNKRLSKGGKKGSKKKILDPFT KKEWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLA-DLQND---EVAFR KFRLMVEDVRGKNCLTNFHGMNLTRDKYCSMVKKWQTLIDANIDVRTTDGYLLRLFCIGF TKRRQNQIKKTSYAQSTQVRAIR-RKMIEIMARECAANDLKEVVNKLIPDSIARDIEKAC HRIYPLHDVHIRKVKVLRKPKFDVSRLMELHGEGSS-TGKTTTTDDTG----AQVDRP-- DGYEPPVQESVMA-RGPKKHL-KRLNAPKHWMLAKLTGNFAPRASTGPHKLRECLPLIIF LRNRLKYALTYVETKKIMMQRLIKVDGKVRTDITYPAGFMDVISINKTGENFRLIYNVKG RFVVHRIGSEEAKFKLCKVRKVWTGPKGVPYLSTHDARTIRYPDPLVKVYDTIKVDITTG KITDHIKFDSGHLCMITGGRNLGRVGTITHREKHPGSFEIVHIKDASDHTYATRLGNVFV IGKANKAYVSLPKG-KGIRLTIAEEREKRIAQRV---XXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXELPEIQLFGRWSCEEVQVSDISLTDYIPVKEKFAKYLPHSSG RYQVKRFRKAQCPIVERITNSMMMHGRNNGKKLLTMRIIKHAFEIIHLLTGENPLQVLVN AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNTKTIAECLA DELINAAKGSSNSYAIKKKDELERVAKSNR---------MAVFNAGA-KVIKPQGESADP FELTVSQALIELESNSELKGQLRELFITGAKEIDVGNSRKAVIVMVPVPQLKAFQ-KIQV RLVRELEKKFSGKHVLFIAQRRILPKPTRKSRNK-SKQKRPRSRTLTMVHDNILEDLVYP SEIVGKRTHIKLDGSRNIKVHLDVGQKTQIEHKTETYGAVYKKLTGKDVTFEFP-EFTV- --MP---KVVCSKTFVTPRRPFEKERLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAAR DLLTREEKDPKRLFEGNSLLRRLVRIGVLDESKMKLDYVLGLRIEDFLERRLQTQVFKLG LAKSIHHARVLIRQRHIRVRKQVVNIPSYIVRLDSQKHIDFSLRSPYGGGRPGRVKRQNM KKGTSGGGGGGDDEDEDMLMPKVNRVAIYENLFKEGVIVAKKDFYSPKHPELES--VPNL HVIKACQSLKSRGYVKEQFAWRHYYWYLTNEGIQYLRDYLHLPPEIVPATLKRQPRTETA RPKPRVIEG-RGGPERGGPPSDGQRQEYRRG--PGGP---DKKGDAGAGATQDFQFKG-G F-GRGRSQ---------PPQ--------MSDAEGDDQPAAAAAAA--AVSVGGPMDVNTA LQEVLKTALIHEGLARGIHEATKALDKRQAHLCVLANNCDEPAYKKLVEALCVEHNINLL KVDDNKKLGEWAGLCKIDKEGKARKVVACSCVAVKDYGKESPALDVVKDYFSK------- -------MAEVEV-------KKKRTFRKYTFRGVDLDQLLDMSNEVLSELLHSRARRRFK RGLKRKPLALLKKLRKAKKECPALEKPEVVKTHLRNVIIVPEMVGCMVGVYNGKVFNQVE IKPDMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLKMAEKEKTPA------QSVQVF GRKKTATAVAHCKQGNGLLKVNGHPLELVQPLALQSKLMEPVYLLGKDRFSAVDIRVRVK GGGRIAQIYAIRQAISKSLVAYYQKFVDEASKKEIKDILIQYDRALLVADPRRCEPKKFG GPGARARYQKSYR-----MGRVRTKTVKKAARVIIEKYYTRLTLDFHTNKRVCEEIAIIP SKRLRNQIAGFVTHLMKRIQKGAVRGISIKLQEEERERRDNYVPEVSALEQ-DIIEVDPD TKDMLKLLDFN-ITNLQVTEPAAPGMAFRGPRL--------------------------M AYS----KDPMKG--PVEEVP----AHRIRITLTSRNVKSLEKVCADLKRGAQEKNLKVK GPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLESPSEIVKQITSISIEPGVE VEVTIADA--MGSGKPRGLRTARKLRTHRRDQRWHDKDYKKAHSSTALKANPFGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEASAEMFYXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAKKRKKKNYTTPKKTKHKKKKVKLA VLKFYKVDENGKITRLRRECPSEECGAGVFMASHFDRQYCGKCCLTYVYNKPAEA----- -----MQLFVRADE-------THTLEVTGE-ESIADLKAKIQELSGFS-ASEQVLSCCGA --PLDEDITLSQNGLVD-LMTLELSGRLLGGKVHGSLARAGKVRGQTPKVDPQEKKK-KK VGRAKRRMQYNRRFVNVVQ-TFGKRRGPNSNS--------- >Hydra MSHRKFEAPRHGNLGFLPRKRSKKQLARMKTFPKDDETKPCHLTGFIGFKAGMTHIVREV DRVGSKVHKKEVVEAVTILETPPIVIVGIVGYVETPRGLRQLTTVWAEHLSDECKRRFYK NWYKSKHKAFTKSSKKWTDENGKKSIERDLEKMIKYCKVIRVLVHTQQKLVGLKQKKAHI MEIQINGGKIADKVNWAKNHLEKTISVSNVFGQDEXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXMGRVIRGQRKGAGSVFRAHTHKRKGAAKLRALDFAERNGYIKGVVRDIVHD SGRGAPLAVVVFRDPYKFKLRKELFIATEGMHTGQFVYCGKKAALTIGNVLPVGVMPEGT IVCNLEEKSGDRGKLARASGDYATVVSHNKESNVTRVKLPSGVKKAIPSFNRASIGIVAG GGRIDKPILKAGRAYHKYKAKRNCWPIVRGVCMNPVEHPHGGGNHQHIGFPSTVARDTPA GRKVGLIAARRTGRVRGAAKIK-DAPEKE-MGRRPARCYRYCKNKPYPKSRFCRGVPDPK IRIFDLGRKRALVDEFPICIHLVSDEWEQLSSEALEAGRICANKYMVKNCGKDAFHIRIR LHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVKIGQTIMSVRTKEGNKAAAHE ALRRAKFKFPGRQKIFDSNKWGFTKWTREEYEKMRAEGKLVPDGVSVQYHPDHGPLNKWK ARMLKN-----------------------------------------------MAPAKEE KKGDKINPMKDIRIQKLCINICVGESGDRLVRAGKVLEALTGQTPVFSKARYTVRSFSIR RNEKIAVHCTVRGAKAEEILEKGLKVKEYELKKSNFSATGNFGFGIAEHIDLGIKYDPSI GIYGMDFYVVLARPGYNIAYRKKKTSTVGFPHRLTKADSMKWFQQKYDGIV--------- --------MGPKFDPTAITIVYLRVIGGEVGATSSLAPKIGPLGLSPKKVGDDIAKATGE WKGLKVTVKLVIQNRNATISVVPSAASLIIKYLKEPPRDRKKVKHVKHNGDITLDNIFDI ARQMRERSLARKFSGTVKEILGTAQSVGCTIDGKSPHDIIESIQSGEIECPEAXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXMGKFMKSGRVVLVLSGRYAGRKAVIVKNHDDGSSDRPYSHALVAGIDRYPRKVT KDMSKKKIKRRSRIKTFVKLFNYNHLMPTRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXMA---KKNDKKKSTKSPMNEVVTREYTINLHKRIHDL PFKKKAPRAIREIKKFAKKMMGTTDVRIDTGLNKYVWSHGIRNVPRRARVRLARRRNEDE DSANKLYTLVTVVKVDSFKKLQTINVEAED-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXMSSHKTFIIKRRLAKKMKQNRAVPQWVRMKTG NTIRYNAKRRHWRRTKLGL----M-AVSQSSELACVYSALILHDDDVPITSEKITKLVAA ANVQ-VEPFWPILFAKALEGRNIGDLICNVG-SAPAAAAPVAAAPAP-AAAAAAKPAA-- -------KEE----KKKEESEP-SDDDMGFGLFDMAVGKNKKLAKGGKKGGKKKVIDPFT RKDWYDVRAPSMFNQRNIGKTIVNRTQGTKIASEGLKGRVFEVSQA-DLHKD---ENGFR KFRLMSEDVSGKNVLTNFHGMTITTDKIRSMVKKWQSLIEAHVDVKTTDGFLLRLFVIAF TKKRANTMRKTAYAQHAQIKEIR-KRMVSIIQREVSTCDLKDVVSKLLPDSIAKDIEKAS QGIYPLHDVHVRKVKVLKKPKFELSKLLELHGEGGKGSATAAVNADG-----VVVERP-- DGYEPPVLASVMT-RGPKKHL-KRLNAPKHWMLDKLSGNFAPRPSPGPHKLRECLPLIVF LRNRLKYALNYAEVTKIMKQRLIKVDGKVRTDICYPAGFMDVVSIERTHENFRLLYDVKG RFVCNRISAEESAYKLAKVKRTAVGQNSIPYIVTHDGRTIRYPDPSIKVNDTVIVDIKTG KITDFIKFDTGNLVMVTAGRNTGRVGIITNRERHPSSYDIVHVKDVTGNQFATRLSNIFL IGKGSKPLVSLPRG-KGVRLTIADERDRRMANK--------------------------- -MEDWGE-PGDEVAATTIEVHDIKLFGKWNPDEVQVSDISLTDYIAVKDKFAVFLPHTAA RYAVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMCVRIVKHAFEIIHLLTGENPLQVLCD AIINSGPREDSTRIGRQGTVRRQAVDVAPLRRVNQAIWLICTGAREAAFRNIKSIAECLA DELINASKGSSNSYAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXMELEVNSDLKNELRELFISGAKEIDIGDKRKCIIIFVPVPLLTRFQ-KIQV RLVRELEKKFSGKHVIVVGQRRILPKPSRKTRN--QKQMRPRSRTLTAEHDAILEDLCFP SEIVGKSIRVKLDGSRLVKIVLEKAQQTNVEHKLDTFANVYKKLTGKDTHFXXXXXXXXX X-MV---RAVCSKTYVSPRRPFEKARLDQELKLIGEYGLRNKREVWRVKYCLAKIRKRAR DLLTLPEKDARRLFEGNALLRRLVRIGVLDEGRMKLDYVLGLKVEDFLERRLQTQVFKLG LAKSIHHARVLIRQKHIRVRKQLVNIPSFIVRLDSQKHIDFSTNSPFGGGRPGRVSRKNM KKGGSGGN-DEEDEDE-XXXPKKNRHAIYEALFKDGVLVAIKDFNSPKHCELEK--IRNL EVIKAMQSLKSRGYVRENFAWRHYYWYLTNEGIQYLRDYLHLPPEIVPATLRKSTK-AAE SVKPWAKG-GDQRSSGPR---DTDRENYRRD--AGAP---EK---GGAGSDFRPEFRA-G F-GIGRGFGA-------PPS--------MSDMEGDDGPVKPTV----VSEAGGRMDINSA LQEVLKLSMIHDGLCRGLRESVKALDKRQAALCVLAKNCDEPMYTKLIEALCAEHSINLL KVDDNKKLGEWAGLCKIDKEGNARKVVGCSCVVVKDWGKETQAHDVLNDYFKAASPLKH- -------M-DNDAA-DL---KKKRTFKKFTFRGVDLDQLLDLSNEQLTGLLHSRARRRCD RGLKSKAARLIKKLTNAKKQAPPLEKPAVVKTHMRDMLVLPSMIGSIIGVHNGKTFNQVE IKPEMIGYYFGEFSMXXXXXXXXXXXXXXXXXXXXIPLKXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXX-----MGRLRTKTVKKASRVIIEKYYTRLTHDFHTNKRICEEIAIIP SKKLRNKIAGFITHLMKRIELGPVRGISIKLQEEERERRDNYVPEVSALEQ-EVIEVDPY TKEMLKVLDFADIPNLQVTQPITAPGLRPAQK---------------------------M SAL----KEKQV----EEEAQ----IHRIRITLTSRNVKSLEKVCTELIRGAKEKKLVVK GPVRIPTKVLRITSRKTPCGEGSKTWSRYEMRIHKRLIDLHSPAEVVKQITSVSIEPGVE VEVTIADS--MG--KPHGIRTARKHRTNRRVQVWADKDYKKAHLGTRWKANPFSGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPKDGCLNFIEENDEVLVAGFGRK GHAVGDIPGVRFKVVKVANVSLLALFKGKKERPRAGKKRKKKNYSTPKKIKHKKKKVKLA VLKHYKVDENGKITRLKRDCPGESCGASVFMAQHFDRYSCGKCSSTYSITKN-------- -----MQFFIHGDS-------ITTYDLSPS-VKISDLKELISFRSGVP-VESQVLTFSGH --CLDDEKTLSECNVDA-LSTVHLGVKILGGKVHGSLARAGKVKGQTPKVDKQEKKKKAL TGRAKRRHQYSQRFVNVVL-IPGRRRGPNSNAA-------- >Podocoryne XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMTHIVREV DRHGSKVHKKEVVEAVTILETPPIVVVGIVGYVDTPRGLRQLTSVWAEHLSEECRRRFYK NWYKSKRKAFTKASKKWSDEDGKKSIERDLEKMKKYCKVIRVIVHTQQKLVHLKQKKAHI MELQVNGGSVADKVDWAKDNLEKTVSINNVFGQNEMIDVIGVTKGKGFKGVTYRWGTKKL PRKTHKGLRKVACIGAWHPARVGFSVPRAGQCGYHHRVERNKKVYRIGRGV-------QK NNASTDYDLTEKTITPMGGFPHYGQVQQDYIMIKGCVPGPKKRVLTLRKSLLAQTSRKAM EKITLKFIDTSSKFGHGRFQHDQEKKSFMGLLKKDRKPEATEA-------------XXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXHASADAWLTIQQPTRPRTRTLRGVKMAKAHTPR NALLAGGISRLSRTAVYKKRALYKRKKVAVKAKKVDEPTTKTKPVGGD-KNGKERVVAVQ KESRFYPTEDVKKPLRNR--KT---QRPTKLRSSLTPGTIVILLAGRHRGKRVVFLKQLP TSGLLLVTGPYKVNGVPLRRVPQSYVIATQTKIDVSKLALPERVDDAVFQRQQK-KKRTS ----DG--MFE-ESSEGYKPSEEKKADQQAVDDAVLAEISKEPXXXXXXXXXXXXXXXXX XXXXXXXXXMGRVIRGQRKGAGSIFKSHTKKRKGAAKLRALDYAERNGYIKGVIKDIIHD PGRGAPLAVVVFRDPYKFKLNKELFIATEGMHTGQFVYCGKKATLQIGNILPLAAMPEGT IICNIEEKSGDRGKLARASGDYATVVSHNRDTKVTRIKLPSGLKKAVPSFNRASVGIVAG GGRIDKPLLKAGRAYHKYKVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGFPSTVKRDTSA GRKVXXXXXXXXXXXXXXXXXXXXXXXXXXMGRRPARCYRYCKNKPYPKSRFCRGVPDSK IRIFDLGKKRTPVDEFPKSVNLVSDEYEQLSAEGLEAARICANKYMIKFAGKDCFHIRIR VHPFHIVRINKMLSCAGADRLQTGMRGAFGKPQGTVARVNIGQPLISIRCKDQHESVAIE ALRRAKFKFPGRQKIFVSKKWGFTRWDRAEYLERRRDGSIKPDGTNVQYYPNKGKLKDWR WRESRC------------------------------------------------------ --------MREIRIQKLCINICVGESGDRLVRAGKVLEALTGQTPVFSKARYTVRSFGIR RNEKIAVHCTVRGPKAEEILEKGLKVKEYELRRRNFSATGNFGFGIAEHIDLGIKYDPGI GIYGMDFYIVLARPGYNIAYRRRKKSKVGFKHKITKADSMKWFQQKYDGILL-NK----- --------MGPKFDPTAITIVYLRAVGGEVGATSSLAPKIGPLGLSPKKVGDDIAKATGD WKGLKITVQLTIQNRQAKISVVPSAASLIIKALKEPPRDRKKVKHVQHNGNITLDNIYDI AREMRPRSIARKFVGTVKEILGTAQSVGCTIDGDAPHDVIDKINSGEIEVPESMGK--YS IDPENPIKSCKARGSYLRVHFKNTRETAQAIKKMHIRKAYRYLKDVIAKKQIIPFRRFCG GVGRKAQAKAFKHTQGRWPVKSAEFLLGLLKNAESNADVKGLDVDSLVIDHIQVNRAPYM RRRTYRAHGRINPYMSSPCHIEMIVSEKEQVVPRA---EEEVEVKK-VS-KKK-LAREK- LKARE-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXMGKKRTNKRSKIKSFVKVVNYNHLMPTRYSV-DVQLNKSHVNKDILKDGSKRRRAKTE IKAKLEERYKSGKNKWFFQKLRFMA---KKTDKKKTTKSPMNEVVTREYTINLHKRIHGM QFKKRAPRAIREIKKFAVKMMGTPDIRIDTGLNKYVWSHGVRNVPRRARVRLARKRNEDE DSANKLYTLVTVVKVDTFKKLQTLNVESED-MGARLVLRRRLSYNTKSNRRRISKTPGGK LVYLYTKKAGATPK--CGDCKDKLRGLKASRPKKLANLSKTKKTISRAYGGSRCAKCVRE RIIRAFLIEEQKLVVRVLRAQQGKGKSA-------------------------------- ----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXMPAHKTFIIKRKLAKKMNQNRPVPQWIRMRTG NKIRYNAKRRHWRRTKLGL----M-AESTTSELACVYSALILYDDDVDITAEKISKLIST ANVE-IEPFWPGLFAKALQGRNIGDLICNVG-SAPA-AAPAAAAGGE-AAAESGQ----- -------KEEE---KKKEESEEESDDDMGFGLFDMAVGKNKRLSKG-KKGTKKKIVDPFS KKDWYDVKAPSNFNVRNIGKTVVTRTIGTKIASDGLKGRVFEMAQA-DLNQD---EVPFR KFKLIVEDVQGRNCITNFHGMTMTTDRLRSLVKKWQTCIEAHVDVKTTDGYLLRVFSIGF TRRRPNSLKKTAYAKSTQVRAIR-KKMVEIITREVSTKDLKDVVSKLLPDSMGTDIEKAC QGIYPLHDCYIRKVKCLKKPKFDVHKLMEMH-EGGTATTATG--DATTG---VPTERP-- DNYEPPVVDSVXXXXXXKKHL-KRLNAPKHWMLDKLSGNFAPRPSPGPHKLRECLPLVVF LRNRLKYALNYTEVTKIMKQRLIKVDGKVRTDTCYPAGFMDVVTVERTGEFFRLLYDVKG RFVCHKISAEESAYKLGKVKRVGFGKNSVPNIVTHDARTIRYPDPSIKVNDTVVIDIKSG KVTDYIKFDTGNTVMVIGGRNTGRVGIITHRERHASSYDIVHIKDAAGNQFATRLSNIFL VGKGNKAMITLPKG-KGVRLTISEERDRRLAHK--------------------------- MAESWGETDETVEEPTSIEVQDIKLFGKWPLEGLNISDISLTDYIAVKDNHAVYLPHTAA RYAVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVRHSFEIMHLLTGENPLQLVCE AISNSGPREDSTRIGRAGTVRRQAVDVAPLRRVNQAIWLLCTGAREASFRNIKSIAECLA DELIXXXXXXXXXXXXXXXXXXXXXXXXXX--------------MFA-KIVKPGGEQPDD LEKSIGEALLELEVNSDLKTQLRELYITGAKELDVGDKKKCLIIFVPVPLLRQFQ-KIQV RLVRELEKKFSGKHVVVVAQRRILPKPTRKTRN--QKQMRPRSRTLTAVHDSILDDLCFP SEIVGKSIRVKLDASRMIKVVLEKAQQTNVEHKLDTFAAVYKKLTGKDTHFSFEIXXXXX X-MV---KNVCSKTYVTPRRPFEKARLDQELQLIGQFGLRNKREVWRVKFSLAKIRKRAR DLLTLPEKDNRRLFEGNALLRRLVRIGVLDESRMKLDYVLGLKVEDFLERRLQTQVFKLG LAKSIHHARVIIRQRHIRVRKQLVNVPSFIVRLDSQKHIDYRQNSPYAGGRAGRVKRKNA KKGGDADA--EEEDDE-MIIPKKNRVAIYEALFKDGALVAIKDFNLAKHGELEK--IPNL QVIKAMQSLKSRGHVRENFAWRHYYWYLTNEGIQYLRDYLHLPPEIVPATLRKK----AD APKPWAKGSGDQRSSGPR-GGDSGRDAYRRG-EGGAS---DK-AGAGS--DFKPEFRA-G FGGLGRGGNATGGGFGAPPS--------MSDAEGDDVSTPQEV--------GGPMDINTA LQEILKQSMIHDGLSRGLRESVKSLDQRQALLCILANNCDEQMYVKLIEALCAEHSINLI KVDDNKKLGEWAGLCKIDKEGKARKVVGCSCVVVKDWGKETQAHDVLMEYFKSKRT---- -------MADLAAAAEL---KKRRTFRKFSFRGVDLDQLLDLSSEQLMELVHARARRRFS RGLKMKPLALMKKLRKAKKEAAPMEKPAVVKTHLRNMIVLPDMIGSIVGVHNGKTFNQVE IKPEMIGHYLGEFSMTYKPVRHGRPGIGATHSSRF-PLKMSTAA--------P-TSVQVF GRKKTATAVAFCKRGNGLIKVNGRPLDLVEPVTLRMKVQEPVLLLGKERFAGIDIRVRVR GGGQIAQLYAIRQAISKAIVAYYQKFVDEASKKEIKDLLVRYDRSLLVADPRRCEAKKFG GPGARARYQKSYRXXXXXXGRVRTKTVKKAARVIIEKYYTRLTHDFHTNKRICEEIAIIP SKKLRNKIAGFITHLMKRIELGPVRGISIKLQEEERERRDNYVPEISALEQ-DPIEVDPD TKEMLKLLDFASIPNLQVMQPITSSGLRMQGGNKM------------------------M SAY----KEKQVQ---EEEAQ----VHRIRITLTSRNVKSLEKVCGELIRGAKDKKLMVK GPVRLPTKTLRITSRKTPCGEGSKTWSRYEMRIHKRLIDLHSPAEVVKQITSVSIEPGVE VEVTIADA--MG--KPRGIRVARKLRTLRREQRWHDKKYKKAHLGTALKANPLGGASHAK GIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFGPNDGCLNYIEENDEVLVSGFGRK GHAVGDIPGVRFKVVKVASVSLLALFKGKKERPRSGKKRKKKNYTTPKKIKHKRKKVKLA VLKYYKVDENGKITRLRRECPSESCGAGVFMAQHFDRQYCGKCCLTYVFSKPGQEAK--- -----MQIFVQGQN-------TNVYDVSTS-ISVGDLKELIAFRSGVP-VEEQVLVYAGH --PLQDEKSLQESDVSV-SSTISLSVRILGGKVHGSLARAGKVKGQTPKVDKQEKKK-PK TGRSKRRQQYNSRFVNAVI-TPGRRRGPNSNA---------